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A comparison of prediction equations for estimating glomerular filtration rate in Chinese potential living kidney donors.
Clin Transplant. 2009 Aug-Sep; 23(4):469-75.CT

Abstract

BACKGROUND

Accurate measurement of donor renal function has important long-term implications for both donors and recipients. In clinical practice, renal function may be estimated by using 24-h urinary creatinine clearance (urine-CrCl) and various specifically derived prediction equations. We assessed the suitability of urine-CrCl and prediction equations for evaluating Chinese kidney donors.

METHODS

A total of 224 donors who had undergone (99m)Tc-diethylenetriaminepentaacetic acid glomerular filtration rate (GFR) estimation were enrolled. We evaluated the performance of the Cockcroft-Gault equation (CG-CrCl), the CG-CrCl equation corrected for GFR (CG-GFR), the isotope dilution mass spectrometry traceable modification of diet in renal disease (IDMS-MDRD) study equation, the new MDRD study equation for Chinese (C-MDRD 1), the modified MDRD study equation with a Chinese coefficient (C-MDRD 2), the modified IDMS-MDRD study equation with a Japanese coefficient (J-MDRD), and urine-CrCl in predicting GFR before donation.

RESULTS

Of 224 donors selected, 68 were male and 156 were female. Of all the prediction equations, C-MDRD 1 was the least scattered and most precise. However, predictive performance was poor for all the equations.

CONCLUSION

The performance of urine-CrCl and all the equations was disappointing, and even the best performing equation C-MDRD 1 was unacceptable. Considering the potential risk of living kidney donation, other more accurate methods of GFR measurement should be used in clinical practice.

Authors+Show Affiliations

Organ Transplantation Institute of PLA, Changzheng Hospital, Second Military Medical University, Shanghai, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19573086

Citation

Zhao, Wen-Yu, et al. "A Comparison of Prediction Equations for Estimating Glomerular Filtration Rate in Chinese Potential Living Kidney Donors." Clinical Transplantation, vol. 23, no. 4, 2009, pp. 469-75.
Zhao WY, Zeng L, Zhu YH, et al. A comparison of prediction equations for estimating glomerular filtration rate in Chinese potential living kidney donors. Clin Transplant. 2009;23(4):469-75.
Zhao, W. Y., Zeng, L., Zhu, Y. H., Wang, L. M., Zhou, M. S., Han, S., & Zhang, L. (2009). A comparison of prediction equations for estimating glomerular filtration rate in Chinese potential living kidney donors. Clinical Transplantation, 23(4), 469-75. https://doi.org/10.1111/j.1399-0012.2009.01027.x
Zhao WY, et al. A Comparison of Prediction Equations for Estimating Glomerular Filtration Rate in Chinese Potential Living Kidney Donors. Clin Transplant. 2009 Aug-Sep;23(4):469-75. PubMed PMID: 19573086.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of prediction equations for estimating glomerular filtration rate in Chinese potential living kidney donors. AU - Zhao,Wen-Yu, AU - Zeng,Li, AU - Zhu,You-Hua, AU - Wang,Li-Ming, AU - Zhou,Mei-Sheng, AU - Han,Shu, AU - Zhang,Lei, Y1 - 2009/06/30/ PY - 2009/7/4/entrez PY - 2009/7/4/pubmed PY - 2009/11/5/medline SP - 469 EP - 75 JF - Clinical transplantation JO - Clin Transplant VL - 23 IS - 4 N2 - BACKGROUND: Accurate measurement of donor renal function has important long-term implications for both donors and recipients. In clinical practice, renal function may be estimated by using 24-h urinary creatinine clearance (urine-CrCl) and various specifically derived prediction equations. We assessed the suitability of urine-CrCl and prediction equations for evaluating Chinese kidney donors. METHODS: A total of 224 donors who had undergone (99m)Tc-diethylenetriaminepentaacetic acid glomerular filtration rate (GFR) estimation were enrolled. We evaluated the performance of the Cockcroft-Gault equation (CG-CrCl), the CG-CrCl equation corrected for GFR (CG-GFR), the isotope dilution mass spectrometry traceable modification of diet in renal disease (IDMS-MDRD) study equation, the new MDRD study equation for Chinese (C-MDRD 1), the modified MDRD study equation with a Chinese coefficient (C-MDRD 2), the modified IDMS-MDRD study equation with a Japanese coefficient (J-MDRD), and urine-CrCl in predicting GFR before donation. RESULTS: Of 224 donors selected, 68 were male and 156 were female. Of all the prediction equations, C-MDRD 1 was the least scattered and most precise. However, predictive performance was poor for all the equations. CONCLUSION: The performance of urine-CrCl and all the equations was disappointing, and even the best performing equation C-MDRD 1 was unacceptable. Considering the potential risk of living kidney donation, other more accurate methods of GFR measurement should be used in clinical practice. SN - 1399-0012 UR - https://www.unboundmedicine.com/medline/citation/19573086/A_comparison_of_prediction_equations_for_estimating_glomerular_filtration_rate_in_Chinese_potential_living_kidney_donors_ L2 - https://doi.org/10.1111/j.1399-0012.2009.01027.x DB - PRIME DP - Unbound Medicine ER -