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Glucose monitoring by microdialysis: performance in a multicentre study.
Diabet Med. 2009 Jul; 26(7):714-21.DM

Abstract

AIMS

The aim of this study was to assess the performance of the Continuous Research Tool (CRT) in a multicentre clinical-experimental study.

METHODS

Three patient groups totalling 28 subjects with diabetes [group A 10 Type 1 (Ulm), group B 10 Type 1 (Neuss), group C eight Type 2 (Aarhus)] participated in this trial. Two CRT microdialysis probes were inserted in parallel in the abdominal subcutaneous tissue for 120 h in each subject. In subjects in group A, glucose excursions were induced on one study day and those in group B underwent a glucose clamp (eu-, hypo- or hyperglycaemic) on one study day. CRT data were calibrated once with a retrospective calibration model based on a run-in time of 24 h and three blood glucose measurements per day.

RESULTS

All analysable experiments, covering a broad range of blood glucose values, yielded highly accurate data for the complete experimental time with a mean relative absolute difference of 12.8 +/- 6.0% and a predictive residual error sum of squares of 15.6 +/- 6.3 (mean +/- SD). Of all measurement results, 98.2% were in zones A and B of the error grid analysis. The average absolute differences were 1.14 mmol/l for Type 1 and 0.88 mmol/l for Type 2 diabetic patients. Relative absolute differences were 16.0% for Type 1 and 12.6% for Type 2 diabetic patients.

CONCLUSIONS

These results demonstrate that this microdialysis system allows reliable continuous glucose monitoring in patients with diabetes of either type.

Authors+Show Affiliations

Department of Endocrinology, Aarhus University Hospital, Aarhus, Denmark. j.k.n@dadlnet.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Multicenter Study

Language

eng

PubMed ID

19573121

Citation

Nielsen, J K., et al. "Glucose Monitoring By Microdialysis: Performance in a Multicentre Study." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 26, no. 7, 2009, pp. 714-21.
Nielsen JK, Freckmann G, Kapitza C, et al. Glucose monitoring by microdialysis: performance in a multicentre study. Diabet Med. 2009;26(7):714-21.
Nielsen, J. K., Freckmann, G., Kapitza, C., Ocvirk, G., Koelker, K. H., Kamecke, U., Gillen, R., Amann-Zalan, I., Jendrike, N., Christiansen, J. S., Koschinsky, T., & Heinemann, L. (2009). Glucose monitoring by microdialysis: performance in a multicentre study. Diabetic Medicine : a Journal of the British Diabetic Association, 26(7), 714-21. https://doi.org/10.1111/j.1464-5491.2009.02750.x
Nielsen JK, et al. Glucose Monitoring By Microdialysis: Performance in a Multicentre Study. Diabet Med. 2009;26(7):714-21. PubMed PMID: 19573121.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glucose monitoring by microdialysis: performance in a multicentre study. AU - Nielsen,J K, AU - Freckmann,G, AU - Kapitza,C, AU - Ocvirk,G, AU - Koelker,K H, AU - Kamecke,U, AU - Gillen,R, AU - Amann-Zalan,I, AU - Jendrike,N, AU - Christiansen,J S, AU - Koschinsky,T, AU - Heinemann,L, PY - 2009/7/4/entrez PY - 2009/7/4/pubmed PY - 2010/2/23/medline SP - 714 EP - 21 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet Med VL - 26 IS - 7 N2 - AIMS: The aim of this study was to assess the performance of the Continuous Research Tool (CRT) in a multicentre clinical-experimental study. METHODS: Three patient groups totalling 28 subjects with diabetes [group A 10 Type 1 (Ulm), group B 10 Type 1 (Neuss), group C eight Type 2 (Aarhus)] participated in this trial. Two CRT microdialysis probes were inserted in parallel in the abdominal subcutaneous tissue for 120 h in each subject. In subjects in group A, glucose excursions were induced on one study day and those in group B underwent a glucose clamp (eu-, hypo- or hyperglycaemic) on one study day. CRT data were calibrated once with a retrospective calibration model based on a run-in time of 24 h and three blood glucose measurements per day. RESULTS: All analysable experiments, covering a broad range of blood glucose values, yielded highly accurate data for the complete experimental time with a mean relative absolute difference of 12.8 +/- 6.0% and a predictive residual error sum of squares of 15.6 +/- 6.3 (mean +/- SD). Of all measurement results, 98.2% were in zones A and B of the error grid analysis. The average absolute differences were 1.14 mmol/l for Type 1 and 0.88 mmol/l for Type 2 diabetic patients. Relative absolute differences were 16.0% for Type 1 and 12.6% for Type 2 diabetic patients. CONCLUSIONS: These results demonstrate that this microdialysis system allows reliable continuous glucose monitoring in patients with diabetes of either type. SN - 1464-5491 UR - https://www.unboundmedicine.com/medline/citation/19573121/Glucose_monitoring_by_microdialysis:_performance_in_a_multicentre_study_ L2 - https://doi.org/10.1111/j.1464-5491.2009.02750.x DB - PRIME DP - Unbound Medicine ER -