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Probiotics and prebiotics in atopic dermatitis: review of the theoretical background and clinical evidence.
Pediatr Allergy Immunol. 2010 Mar; 21(2 Pt 2):e355-67.PA

Abstract

The prevalence of atopic dermatitis (AD) has risen over the past decades, especially in western societies. According to the revised hygiene hypothesis this increase is caused by a changed intestinal colonization pattern during infancy, which has an impact on the immune system. Manipulating the intestinal microflora with pro-, pre- or synbiotics is an innovative way to prevent or treat AD. This review provides an overview of the theoretical basis for using probiotics and prebiotics in AD and presents the current evidence from randomized controlled trials (RCTs) regarding prevention and treatment of AD and food allergy in children with pro-, pre- and synbiotics. Seven RCTs on prevention and 12 RCTs on treatment were found by searching the Pubmed, Embase and Cochrane databases. Results of these trials are conflicting. In conclusion, at this moment there is not enough evidence to support the use of pro-, pre- or synbiotics for prevention or treatment of AD in children in clinical practice.

Authors+Show Affiliations

Department of Pediatric Respiratory Medicine, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands. l.b.vanderaa@amc.nlNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19573143

Citation

van der Aa, Leontien B., et al. "Probiotics and Prebiotics in Atopic Dermatitis: Review of the Theoretical Background and Clinical Evidence." Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, vol. 21, no. 2 Pt 2, 2010, pp. e355-67.
van der Aa LB, Heymans HS, van Aalderen WM, et al. Probiotics and prebiotics in atopic dermatitis: review of the theoretical background and clinical evidence. Pediatr Allergy Immunol. 2010;21(2 Pt 2):e355-67.
van der Aa, L. B., Heymans, H. S., van Aalderen, W. M., & Sprikkelman, A. B. (2010). Probiotics and prebiotics in atopic dermatitis: review of the theoretical background and clinical evidence. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, 21(2 Pt 2), e355-67. https://doi.org/10.1111/j.1399-3038.2009.00915.x
van der Aa LB, et al. Probiotics and Prebiotics in Atopic Dermatitis: Review of the Theoretical Background and Clinical Evidence. Pediatr Allergy Immunol. 2010;21(2 Pt 2):e355-67. PubMed PMID: 19573143.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Probiotics and prebiotics in atopic dermatitis: review of the theoretical background and clinical evidence. AU - van der Aa,Leontien B, AU - Heymans,Hugo S A, AU - van Aalderen,Wim M C, AU - Sprikkelman,Aline B, Y1 - 2009/07/02/ PY - 2009/7/4/entrez PY - 2009/7/4/pubmed PY - 2010/8/24/medline SP - e355 EP - 67 JF - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JO - Pediatr Allergy Immunol VL - 21 IS - 2 Pt 2 N2 - The prevalence of atopic dermatitis (AD) has risen over the past decades, especially in western societies. According to the revised hygiene hypothesis this increase is caused by a changed intestinal colonization pattern during infancy, which has an impact on the immune system. Manipulating the intestinal microflora with pro-, pre- or synbiotics is an innovative way to prevent or treat AD. This review provides an overview of the theoretical basis for using probiotics and prebiotics in AD and presents the current evidence from randomized controlled trials (RCTs) regarding prevention and treatment of AD and food allergy in children with pro-, pre- and synbiotics. Seven RCTs on prevention and 12 RCTs on treatment were found by searching the Pubmed, Embase and Cochrane databases. Results of these trials are conflicting. In conclusion, at this moment there is not enough evidence to support the use of pro-, pre- or synbiotics for prevention or treatment of AD in children in clinical practice. SN - 1399-3038 UR - https://www.unboundmedicine.com/medline/citation/19573143/Probiotics_and_prebiotics_in_atopic_dermatitis:_review_of_the_theoretical_background_and_clinical_evidence_ L2 - https://doi.org/10.1111/j.1399-3038.2009.00915.x DB - PRIME DP - Unbound Medicine ER -