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Changes in physiology with increasing fat mass.
Semin Pediatr Surg. 2009 Aug; 18(3):126-35.SP

Abstract

Obesity has reached epidemic proportions in the USA with a nearly fourfold rise in the prevalence of childhood obesity. There are many possible etiologies of obesity as the adipose tissue plays a significant, complex role in the physiology of fuel metabolism and hormone regulation. The development of obesity represents a pathophysiologic increase in fat mass in which multiple metabolic pathways are deranged. The consequences of these metabolic derangements, including insulin resistance and inflammation, are reflected in obesity-related comorbidities and can be seen in the setting of pediatric obesity. Obese adolescents demonstrate increased rates of early maturation, orthopedic growth abnormalities, diabetes mellitus, obstructive sleep apnea, hypertension, steatosis, and polycystic ovarian syndrome, placing this group of children at risk for long-term health problems and reduced quality of life. Given the negative short- and long-term impact of obesity on children, careful attention should be paid to the unique health issues of this "at-risk" population with both prevention and early intervention strategies.

Authors+Show Affiliations

Division of Endocrinology, Department of Pediatrics, The Ohio State University Hospitals and Nationwide Children's Hospital, Columbus, Ohio 43210, USA. dara.schuster@osumc.edu

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19573754

Citation

Schuster, Dara P.. "Changes in Physiology With Increasing Fat Mass." Seminars in Pediatric Surgery, vol. 18, no. 3, 2009, pp. 126-35.
Schuster DP. Changes in physiology with increasing fat mass. Semin Pediatr Surg. 2009;18(3):126-35.
Schuster, D. P. (2009). Changes in physiology with increasing fat mass. Seminars in Pediatric Surgery, 18(3), 126-35. https://doi.org/10.1053/j.sempedsurg.2009.04.002
Schuster DP. Changes in Physiology With Increasing Fat Mass. Semin Pediatr Surg. 2009;18(3):126-35. PubMed PMID: 19573754.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in physiology with increasing fat mass. A1 - Schuster,Dara P, PY - 2009/7/4/entrez PY - 2009/7/4/pubmed PY - 2009/11/3/medline SP - 126 EP - 35 JF - Seminars in pediatric surgery JO - Semin Pediatr Surg VL - 18 IS - 3 N2 - Obesity has reached epidemic proportions in the USA with a nearly fourfold rise in the prevalence of childhood obesity. There are many possible etiologies of obesity as the adipose tissue plays a significant, complex role in the physiology of fuel metabolism and hormone regulation. The development of obesity represents a pathophysiologic increase in fat mass in which multiple metabolic pathways are deranged. The consequences of these metabolic derangements, including insulin resistance and inflammation, are reflected in obesity-related comorbidities and can be seen in the setting of pediatric obesity. Obese adolescents demonstrate increased rates of early maturation, orthopedic growth abnormalities, diabetes mellitus, obstructive sleep apnea, hypertension, steatosis, and polycystic ovarian syndrome, placing this group of children at risk for long-term health problems and reduced quality of life. Given the negative short- and long-term impact of obesity on children, careful attention should be paid to the unique health issues of this "at-risk" population with both prevention and early intervention strategies. SN - 1532-9453 UR - https://www.unboundmedicine.com/medline/citation/19573754/Changes_in_physiology_with_increasing_fat_mass_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1055-8586(09)00022-5 DB - PRIME DP - Unbound Medicine ER -