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Diagnosis and treatment of pediatric nonalcoholic steatohepatitis and the implications for bariatric surgery.
Semin Pediatr Surg 2009; 18(3):144-51SP

Abstract

This review focuses on the diagnosis, risk factors, prevalence, pathogenesis and treatment of pediatric nonalcoholic steatohepatitis (NASH). NASH is a progressive form of nonalcoholic fatty liver disease (NAFLD), the most common cause of chronic liver disease in children. The factors that account for differences between children with NASH and children with milder forms of NAFLD are unclear. The diagnosis of NASH requires interpretation of liver histology because no noninvasive markers predict the presence or severity of NASH. There is no proven treatment for NASH. Several clinical trials for NAFLD are in progress; however, clinical trials focusing on NASH are needed. Heightened physician awareness of NAFLD, NASH, and associated risk factors is important to identify and treat affected children.

Authors+Show Affiliations

Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Diego, and Rady Children's Hospital, San Diego, California CA 92103-8450, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19573756

Citation

Pardee, Perrie E., et al. "Diagnosis and Treatment of Pediatric Nonalcoholic Steatohepatitis and the Implications for Bariatric Surgery." Seminars in Pediatric Surgery, vol. 18, no. 3, 2009, pp. 144-51.
Pardee PE, Lavine JE, Schwimmer JB. Diagnosis and treatment of pediatric nonalcoholic steatohepatitis and the implications for bariatric surgery. Semin Pediatr Surg. 2009;18(3):144-51.
Pardee, P. E., Lavine, J. E., & Schwimmer, J. B. (2009). Diagnosis and treatment of pediatric nonalcoholic steatohepatitis and the implications for bariatric surgery. Seminars in Pediatric Surgery, 18(3), pp. 144-51. doi:10.1053/j.sempedsurg.2009.04.004.
Pardee PE, Lavine JE, Schwimmer JB. Diagnosis and Treatment of Pediatric Nonalcoholic Steatohepatitis and the Implications for Bariatric Surgery. Semin Pediatr Surg. 2009;18(3):144-51. PubMed PMID: 19573756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis and treatment of pediatric nonalcoholic steatohepatitis and the implications for bariatric surgery. AU - Pardee,Perrie E, AU - Lavine,Joel E, AU - Schwimmer,Jeffrey B, PY - 2009/7/4/entrez PY - 2009/7/4/pubmed PY - 2009/11/3/medline SP - 144 EP - 51 JF - Seminars in pediatric surgery JO - Semin. Pediatr. Surg. VL - 18 IS - 3 N2 - This review focuses on the diagnosis, risk factors, prevalence, pathogenesis and treatment of pediatric nonalcoholic steatohepatitis (NASH). NASH is a progressive form of nonalcoholic fatty liver disease (NAFLD), the most common cause of chronic liver disease in children. The factors that account for differences between children with NASH and children with milder forms of NAFLD are unclear. The diagnosis of NASH requires interpretation of liver histology because no noninvasive markers predict the presence or severity of NASH. There is no proven treatment for NASH. Several clinical trials for NAFLD are in progress; however, clinical trials focusing on NASH are needed. Heightened physician awareness of NAFLD, NASH, and associated risk factors is important to identify and treat affected children. SN - 1532-9453 UR - https://www.unboundmedicine.com/medline/citation/19573756/Diagnosis_and_treatment_of_pediatric_nonalcoholic_steatohepatitis_and_the_implications_for_bariatric_surgery_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1055-8586(09)00024-9 DB - PRIME DP - Unbound Medicine ER -