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[In vitro activity of daptomycin and other antimicrobial agents against 499 strains of gram-positive cocci causing bloodstream infection].
Zhonghua Nei Ke Za Zhi. 2009 Mar; 48(3):220-4.ZN

Abstract

OBJECTIVE

To evaluate the in vitro activity of daptomycin, vancomycin, teicoplanin, tigecycline, ceftobiprole and linezolid against 499 strains of blood-isolated gram-positive cocci.

METHODS

Determination of the minimal inhibitory concentration (MICs) of daptomycin with microbrothdilution method and the MICs of other 9 antimicrobial agents with agar dilution method against 499 strains of blood-isolated gram positive cocci was carried out. The data was analyzed with WHONET 5.4 software.

RESULTS

The susceptibility rates of staphylococci to daptomycin, tigecycline, linezolid, ceftobiprole, vancomycin and teicoplanin were 100%. All staphylococcus strains were inhibited by daptomycin at a MIC of 1 mg/L. The MIC(50) and MIC(90) of daptomycin were both 0.5 mg/L against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus coagulase-negative (MRSCoN). Among Enterococcus spp, the highest MIC of daptomycin was 4 mg/L. The MIC(50) and MIC(90) of daptomycin were both 2 mg/L against E.faecalis, whereas they were 2 mg/L and 4 mg/L against E.faecium. One strains of linezolid-resistant E.faecalis (MIC: 8 mg/L) was susceptible to daptomycin (MIC: 1 mg/L). Three strains of E.faecium carrying vanA gene with vancomycin MICs above 32 mg/L and teicoplanin MICs also 32 mg/L were susceptible to daptomycin, tigecycline and linezolid. The MIC range of daptomycin against Streptococcus pneumoniae and Streptococcus viridans was 0.032 - 0.25 mg/L and 0.125 - 1.000 mg/L separately.

CONCLUSIONS

Daptomycin has excellent in vitro activity against common gram-positive pathogens isolated from blood. It may be a good choice for clinicians to treat drug-resistant gram-positive cocci.

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Publisher Full Text

Authors+Show Affiliations

Yang QW
Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Wang H
No affiliation info available
Sun HL
No affiliation info available
Xu YC
No affiliation info available
Xie XL
No affiliation info available
Chen MJ
No affiliation info available

MeSH

BacteremiaDaptomycinGram-Positive Bacterial InfectionsGram-Positive CocciHumansMicrobial Sensitivity Tests

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

19576091

Citation

Yang, Qi-Wen, et al. "[In Vitro Activity of Daptomycin and Other Antimicrobial Agents Against 499 Strains of Gram-positive Cocci Causing Bloodstream Infection]." Zhonghua Nei Ke Za Zhi, vol. 48, no. 3, 2009, pp. 220-4.
Yang QW, Wang H, Sun HL, et al. [In vitro activity of daptomycin and other antimicrobial agents against 499 strains of gram-positive cocci causing bloodstream infection]. Zhonghua Nei Ke Za Zhi. 2009;48(3):220-4.
Yang, Q. W., Wang, H., Sun, H. L., Xu, Y. C., Xie, X. L., & Chen, M. J. (2009). [In vitro activity of daptomycin and other antimicrobial agents against 499 strains of gram-positive cocci causing bloodstream infection]. Zhonghua Nei Ke Za Zhi, 48(3), 220-4.
Yang QW, et al. [In Vitro Activity of Daptomycin and Other Antimicrobial Agents Against 499 Strains of Gram-positive Cocci Causing Bloodstream Infection]. Zhonghua Nei Ke Za Zhi. 2009;48(3):220-4. PubMed PMID: 19576091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [In vitro activity of daptomycin and other antimicrobial agents against 499 strains of gram-positive cocci causing bloodstream infection]. AU - Yang,Qi-Wen, AU - Wang,Hui, AU - Sun,Hong-Li, AU - Xu,Ying-Chun, AU - Xie,Xiu-Li, AU - Chen,Min-Jun, PY - 2009/7/7/entrez PY - 2009/7/7/pubmed PY - 2009/10/2/medline SP - 220 EP - 4 JF - Zhonghua nei ke za zhi JO - Zhonghua Nei Ke Za Zhi VL - 48 IS - 3 N2 - OBJECTIVE: To evaluate the in vitro activity of daptomycin, vancomycin, teicoplanin, tigecycline, ceftobiprole and linezolid against 499 strains of blood-isolated gram-positive cocci. METHODS: Determination of the minimal inhibitory concentration (MICs) of daptomycin with microbrothdilution method and the MICs of other 9 antimicrobial agents with agar dilution method against 499 strains of blood-isolated gram positive cocci was carried out. The data was analyzed with WHONET 5.4 software. RESULTS: The susceptibility rates of staphylococci to daptomycin, tigecycline, linezolid, ceftobiprole, vancomycin and teicoplanin were 100%. All staphylococcus strains were inhibited by daptomycin at a MIC of 1 mg/L. The MIC(50) and MIC(90) of daptomycin were both 0.5 mg/L against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus coagulase-negative (MRSCoN). Among Enterococcus spp, the highest MIC of daptomycin was 4 mg/L. The MIC(50) and MIC(90) of daptomycin were both 2 mg/L against E.faecalis, whereas they were 2 mg/L and 4 mg/L against E.faecium. One strains of linezolid-resistant E.faecalis (MIC: 8 mg/L) was susceptible to daptomycin (MIC: 1 mg/L). Three strains of E.faecium carrying vanA gene with vancomycin MICs above 32 mg/L and teicoplanin MICs also 32 mg/L were susceptible to daptomycin, tigecycline and linezolid. The MIC range of daptomycin against Streptococcus pneumoniae and Streptococcus viridans was 0.032 - 0.25 mg/L and 0.125 - 1.000 mg/L separately. CONCLUSIONS: Daptomycin has excellent in vitro activity against common gram-positive pathogens isolated from blood. It may be a good choice for clinicians to treat drug-resistant gram-positive cocci. SN - 0578-1426 UR - https://www.unboundmedicine.com/medline/citation/19576091/[In_vitro_activity_of_daptomycin_and_other_antimicrobial_agents_against_499_strains_of_gram_positive_cocci_causing_bloodstream_infection]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0578-1426&year=2009&vol=48&issue=3&fpage=220 DB - PRIME DP - Unbound Medicine ER -