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Plasma N-terminal prohormone brain natriuretic peptide as a marker for postoperative cardiac events in high-risk patients undergoing noncardiac surgery.
Am J Cardiol 2009; 104(1):137-40AJ

Abstract

This study considered if N-terminal prohormone brain natriuretic peptide (NT-proBNP) is associated with increased risk for postoperative cardiac events in high-risk patients undergoing noncardiac surgery. In addition, this report describes how levels of NT-proBNP are affected by noncardiac surgery. The study design was a prospective cohort study that enrolled 83 patients age > or =50 years with > or =1 risk factor for coronary artery disease having intermediate or high-risk noncardiac surgery. NT-proBNP levels were measured preoperatively and on postoperative days 1 and 3. During the month following surgery, 25 patients (33%) had a combined 37 postoperative cardiac events including 15 episodes of heart failure (20%), 12 episodes of new dysrhythmia (16%), 7 myocardial infarctions (9%), and 3 cardiac arrests (4%). Preoperative NT-proBNP level > or =457 pg/ml was significantly associated with occurrence of a postoperative cardiac event (odds ratio 10.5, 95% confidence interval 1.9 to 56.6, p = 0.006). After surgery, 64 of 72 patients (89%) had an increase in NT-proBNP from their preoperative level. In conclusion, this study determined there was a significant association between elevated preoperative NT-proBNP and occurrence of a postoperative cardiac event. In addition, increased NT-proBNP after noncardiac surgery is not uncommon even in the absence of clinically identifiable heart failure.

Authors+Show Affiliations

Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA. rob.schutt@gmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19576335

Citation

Schutt, Robert Clark, et al. "Plasma N-terminal Prohormone Brain Natriuretic Peptide as a Marker for Postoperative Cardiac Events in High-risk Patients Undergoing Noncardiac Surgery." The American Journal of Cardiology, vol. 104, no. 1, 2009, pp. 137-40.
Schutt RC, Cevik C, Phy MP. Plasma N-terminal prohormone brain natriuretic peptide as a marker for postoperative cardiac events in high-risk patients undergoing noncardiac surgery. Am J Cardiol. 2009;104(1):137-40.
Schutt, R. C., Cevik, C., & Phy, M. P. (2009). Plasma N-terminal prohormone brain natriuretic peptide as a marker for postoperative cardiac events in high-risk patients undergoing noncardiac surgery. The American Journal of Cardiology, 104(1), pp. 137-40. doi:10.1016/j.amjcard.2009.03.005.
Schutt RC, Cevik C, Phy MP. Plasma N-terminal Prohormone Brain Natriuretic Peptide as a Marker for Postoperative Cardiac Events in High-risk Patients Undergoing Noncardiac Surgery. Am J Cardiol. 2009 Jul 1;104(1):137-40. PubMed PMID: 19576335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma N-terminal prohormone brain natriuretic peptide as a marker for postoperative cardiac events in high-risk patients undergoing noncardiac surgery. AU - Schutt,Robert Clark, AU - Cevik,Cihan, AU - Phy,Michael P, Y1 - 2009/05/13/ PY - 2009/01/01/received PY - 2009/03/01/revised PY - 2009/03/01/accepted PY - 2009/7/7/entrez PY - 2009/7/7/pubmed PY - 2009/7/25/medline SP - 137 EP - 40 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 104 IS - 1 N2 - This study considered if N-terminal prohormone brain natriuretic peptide (NT-proBNP) is associated with increased risk for postoperative cardiac events in high-risk patients undergoing noncardiac surgery. In addition, this report describes how levels of NT-proBNP are affected by noncardiac surgery. The study design was a prospective cohort study that enrolled 83 patients age > or =50 years with > or =1 risk factor for coronary artery disease having intermediate or high-risk noncardiac surgery. NT-proBNP levels were measured preoperatively and on postoperative days 1 and 3. During the month following surgery, 25 patients (33%) had a combined 37 postoperative cardiac events including 15 episodes of heart failure (20%), 12 episodes of new dysrhythmia (16%), 7 myocardial infarctions (9%), and 3 cardiac arrests (4%). Preoperative NT-proBNP level > or =457 pg/ml was significantly associated with occurrence of a postoperative cardiac event (odds ratio 10.5, 95% confidence interval 1.9 to 56.6, p = 0.006). After surgery, 64 of 72 patients (89%) had an increase in NT-proBNP from their preoperative level. In conclusion, this study determined there was a significant association between elevated preoperative NT-proBNP and occurrence of a postoperative cardiac event. In addition, increased NT-proBNP after noncardiac surgery is not uncommon even in the absence of clinically identifiable heart failure. SN - 1879-1913 UR - https://www.unboundmedicine.com/medline/citation/19576335/Plasma_N_terminal_prohormone_brain_natriuretic_peptide_as_a_marker_for_postoperative_cardiac_events_in_high_risk_patients_undergoing_noncardiac_surgery_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(09)00675-4 DB - PRIME DP - Unbound Medicine ER -