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Usefulness of beta blockers in high-risk patients after myocardial infarction in conjunction with captopril and/or valsartan (from the VALsartan In Acute Myocardial Infarction [VALIANT] trial).
Am J Cardiol. 2009 Jul 15; 104(2):151-7.AJ

Abstract

Concern has been raised about combining beta blockers with angiotensin-receptor blockers in patients with heart failure. The VALsartan In Acute myocardial infarction (VALIANT) trial enrolled 14,703 patients with myocardial infarction complicated by heart failure or documented left ventricular systolic dysfunction. These patients were randomly allocated to treatment with valsartan, captopril, or both. Physicians were also encouraged to prescribe beta blockers because of previous evidence of benefit. The baseline characteristics, treatments, and outcomes were compared among 4 groups: patients taking beta blockers at admission only, at discharge only, at both admission and discharge, and neither. Patients treated with beta blockers were at lower risk than those not treated at any period. Those treated with beta blockers at both intervals had a lower 3-year mortality rate (17.7%) than those treated only at randomization (30.7%) or only at discharge (25.9%). The greatest mortality (35.1%) occurred in patients not treated at either point. No statistically significant interaction with prognosis was observed between beta-blocker use and treatment with valsartan or valsartan plus captopril. Patients discharged with a beta blocker had a significant survival advantage after adjustment for differences in baseline characteristics and intervening complications (hazard ratio 0.89, 95% confidence interval 0.81 to 0.98, p = 0.02). This association was most pronounced in patients prescribed consistent beta blockers at randomization and discharge and was present in both patients with impaired and those with preserved systolic left ventricular function. These results have further confirmed that beta blockers reduce the risk of death and nonfatal cardiovascular events in patients with heart failure or systolic left ventricular dysfunction after myocardial infarction. In conclusion, no evidence was found of adverse interactions between the angiotensin-receptor blocker valsartan and beta blockers or of a negative effect of the combination of valsartan, captopril, and beta blockers.

Authors+Show Affiliations

Duke Translational Medicine Institute, Durham, North Carolina, USA. calif001@mc.duke.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19576338

Citation

Califf, Robert M., et al. "Usefulness of Beta Blockers in High-risk Patients After Myocardial Infarction in Conjunction With Captopril And/or Valsartan (from the VALsartan in Acute Myocardial Infarction [VALIANT] Trial)." The American Journal of Cardiology, vol. 104, no. 2, 2009, pp. 151-7.
Califf RM, Lokhnygina Y, Velazquez EJ, et al. Usefulness of beta blockers in high-risk patients after myocardial infarction in conjunction with captopril and/or valsartan (from the VALsartan In Acute Myocardial Infarction [VALIANT] trial). Am J Cardiol. 2009;104(2):151-7.
Califf, R. M., Lokhnygina, Y., Velazquez, E. J., McMurray, J. J., Leimberger, J. D., Lewis, E. F., Diaz, R., Murin, J., & Pfeffer, M. A. (2009). Usefulness of beta blockers in high-risk patients after myocardial infarction in conjunction with captopril and/or valsartan (from the VALsartan In Acute Myocardial Infarction [VALIANT] trial). The American Journal of Cardiology, 104(2), 151-7. https://doi.org/10.1016/j.amjcard.2009.03.020
Califf RM, et al. Usefulness of Beta Blockers in High-risk Patients After Myocardial Infarction in Conjunction With Captopril And/or Valsartan (from the VALsartan in Acute Myocardial Infarction [VALIANT] Trial). Am J Cardiol. 2009 Jul 15;104(2):151-7. PubMed PMID: 19576338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Usefulness of beta blockers in high-risk patients after myocardial infarction in conjunction with captopril and/or valsartan (from the VALsartan In Acute Myocardial Infarction [VALIANT] trial). AU - Califf,Robert M, AU - Lokhnygina,Yuliya, AU - Velazquez,Eric J, AU - McMurray,John J V, AU - Leimberger,Jeffrey D, AU - Lewis,Eldrin F, AU - Diaz,Rafael, AU - Murin,Jan, AU - Pfeffer,Marc A, Y1 - 2009/06/03/ PY - 2009/01/02/received PY - 2009/03/03/revised PY - 2009/03/03/accepted PY - 2009/7/7/entrez PY - 2009/7/7/pubmed PY - 2009/7/22/medline SP - 151 EP - 7 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 104 IS - 2 N2 - Concern has been raised about combining beta blockers with angiotensin-receptor blockers in patients with heart failure. The VALsartan In Acute myocardial infarction (VALIANT) trial enrolled 14,703 patients with myocardial infarction complicated by heart failure or documented left ventricular systolic dysfunction. These patients were randomly allocated to treatment with valsartan, captopril, or both. Physicians were also encouraged to prescribe beta blockers because of previous evidence of benefit. The baseline characteristics, treatments, and outcomes were compared among 4 groups: patients taking beta blockers at admission only, at discharge only, at both admission and discharge, and neither. Patients treated with beta blockers were at lower risk than those not treated at any period. Those treated with beta blockers at both intervals had a lower 3-year mortality rate (17.7%) than those treated only at randomization (30.7%) or only at discharge (25.9%). The greatest mortality (35.1%) occurred in patients not treated at either point. No statistically significant interaction with prognosis was observed between beta-blocker use and treatment with valsartan or valsartan plus captopril. Patients discharged with a beta blocker had a significant survival advantage after adjustment for differences in baseline characteristics and intervening complications (hazard ratio 0.89, 95% confidence interval 0.81 to 0.98, p = 0.02). This association was most pronounced in patients prescribed consistent beta blockers at randomization and discharge and was present in both patients with impaired and those with preserved systolic left ventricular function. These results have further confirmed that beta blockers reduce the risk of death and nonfatal cardiovascular events in patients with heart failure or systolic left ventricular dysfunction after myocardial infarction. In conclusion, no evidence was found of adverse interactions between the angiotensin-receptor blocker valsartan and beta blockers or of a negative effect of the combination of valsartan, captopril, and beta blockers. SN - 1879-1913 UR - https://www.unboundmedicine.com/medline/citation/19576338/Usefulness_of_beta_blockers_in_high_risk_patients_after_myocardial_infarction_in_conjunction_with_captopril_and/or_valsartan__from_the_VALsartan_In_Acute_Myocardial_Infarction_[VALIANT]_trial__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(09)00724-3 DB - PRIME DP - Unbound Medicine ER -