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Dietary folate and vitamin B12 intake before diagnosis decreases gastric cancer mortality risk among susceptible MTHFR 677TT carriers.
Nutrition. 2010 Feb; 26(2):201-8.N

Abstract

OBJECTIVE

To assess gastric cancer survival in relation to dietary intake of methyl donors and the methylenetetrahydrofolate reductase 677C>T (MTHFR 677C>T) polymorphism.

METHODS

A prospective cohort of 257 incidental, histologically confirmed gastric cancer cases was assembled in January 2004 and followed until June 2006. Patients were recruited from the main oncology and/or gastroenterology units in Mexico City and were queried regarding their sociodemographic information, clinical history, and dietary habits 3 y before the onset of their symptoms. The intake of methyl donors was estimated with a food-frequency questionnaire and the MTHFR 677C>T polymorphisms were determined by polymerase chain reaction/restriction fragment length polymorphism analysis. Cox's multivariate regression models were used to estimate the mortality risk of gastric cancer.

RESULTS

MTHFR 677TT carriers with low folate and vitamin B12 intakes had the lowest survival rate in cases of gastric cancer. High intakes of folate and vitamin B12 before diagnosis was associated with decreased gastric cancer mortality risk in susceptible MTHFR 677TT carriers (mortality risk for folate 0.14, 95% confidence interval 0.04-0.46, P for trend=0.001; mortality risk for vitamin B12 0.23, 95% confidence interval 0.08-0.66, P for trend=0.008).

CONCLUSION

Folate and related B vitamins may be used as an intervention strategy to improve the survival outcome of gastric cancer.

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Authors+Show Affiliations

Galván-Portillo MV
Center of Population Health Research, National Institute of Public Health, Cuernavaca, Morelos, Mexico.
Oñate-Ocaña LF
No affiliation info available
Pérez-Pérez GI
No affiliation info available
Chen J
No affiliation info available
Herrera-Goepfert R
No affiliation info available
Chihu-Amparan L
No affiliation info available
Flores-Luna L
No affiliation info available
Mohar-Betancourt A
No affiliation info available
López-Carrillo L
No affiliation info available

MeSH

AdultAgedDietDiet SurveysFemaleFolic AcidGenetic Predisposition to DiseaseHumansMaleMethylenetetrahydrofolate Reductase (NADPH2)MexicoMiddle AgedPolymorphism, Single NucleotideProportional Hazards ModelsProspective StudiesRisk FactorsStomach NeoplasmsSurveys and QuestionnairesSurvival AnalysisVitamin B 12Vitamin B ComplexYoung Adult

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19577428

Citation

Galván-Portillo, Marcia V., et al. "Dietary Folate and Vitamin B12 Intake Before Diagnosis Decreases Gastric Cancer Mortality Risk Among Susceptible MTHFR 677TT Carriers." Nutrition (Burbank, Los Angeles County, Calif.), vol. 26, no. 2, 2010, pp. 201-8.
Galván-Portillo MV, Oñate-Ocaña LF, Pérez-Pérez GI, et al. Dietary folate and vitamin B12 intake before diagnosis decreases gastric cancer mortality risk among susceptible MTHFR 677TT carriers. Nutrition. 2010;26(2):201-8.
Galván-Portillo, M. V., Oñate-Ocaña, L. F., Pérez-Pérez, G. I., Chen, J., Herrera-Goepfert, R., Chihu-Amparan, L., Flores-Luna, L., Mohar-Betancourt, A., & López-Carrillo, L. (2010). Dietary folate and vitamin B12 intake before diagnosis decreases gastric cancer mortality risk among susceptible MTHFR 677TT carriers. Nutrition (Burbank, Los Angeles County, Calif.), 26(2), 201-8. https://doi.org/10.1016/j.nut.2009.05.006
Galván-Portillo MV, et al. Dietary Folate and Vitamin B12 Intake Before Diagnosis Decreases Gastric Cancer Mortality Risk Among Susceptible MTHFR 677TT Carriers. Nutrition. 2010;26(2):201-8. PubMed PMID: 19577428.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary folate and vitamin B12 intake before diagnosis decreases gastric cancer mortality risk among susceptible MTHFR 677TT carriers. AU - Galván-Portillo,Marcia V, AU - Oñate-Ocaña,Luis F, AU - Pérez-Pérez,Guillermo I, AU - Chen,Jia, AU - Herrera-Goepfert,Roberto, AU - Chihu-Amparan,Lilia, AU - Flores-Luna,Lourdes, AU - Mohar-Betancourt,Alejandro, AU - López-Carrillo,Lizbeth, Y1 - 2009/07/03/ PY - 2008/10/21/received PY - 2009/04/27/revised PY - 2009/05/03/accepted PY - 2009/7/7/entrez PY - 2009/7/7/pubmed PY - 2010/5/28/medline SP - 201 EP - 8 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 26 IS - 2 N2 - OBJECTIVE: To assess gastric cancer survival in relation to dietary intake of methyl donors and the methylenetetrahydrofolate reductase 677C>T (MTHFR 677C>T) polymorphism. METHODS: A prospective cohort of 257 incidental, histologically confirmed gastric cancer cases was assembled in January 2004 and followed until June 2006. Patients were recruited from the main oncology and/or gastroenterology units in Mexico City and were queried regarding their sociodemographic information, clinical history, and dietary habits 3 y before the onset of their symptoms. The intake of methyl donors was estimated with a food-frequency questionnaire and the MTHFR 677C>T polymorphisms were determined by polymerase chain reaction/restriction fragment length polymorphism analysis. Cox's multivariate regression models were used to estimate the mortality risk of gastric cancer. RESULTS: MTHFR 677TT carriers with low folate and vitamin B12 intakes had the lowest survival rate in cases of gastric cancer. High intakes of folate and vitamin B12 before diagnosis was associated with decreased gastric cancer mortality risk in susceptible MTHFR 677TT carriers (mortality risk for folate 0.14, 95% confidence interval 0.04-0.46, P for trend=0.001; mortality risk for vitamin B12 0.23, 95% confidence interval 0.08-0.66, P for trend=0.008). CONCLUSION: Folate and related B vitamins may be used as an intervention strategy to improve the survival outcome of gastric cancer. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/19577428/Dietary_folate_and_vitamin_B12_intake_before_diagnosis_decreases_gastric_cancer_mortality_risk_among_susceptible_MTHFR_677TT_carriers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(09)00224-X DB - PRIME DP - Unbound Medicine ER -