Tags

Type your tag names separated by a space and hit enter

Cancer chemopreventive activity of diversin from Ferula diversivittata in vitro and in vivo.
Phytomedicine. 2010 Mar; 17(3-4):269-73.P

Abstract

A prenylated coumarin (diversin, 1) together with four new sesquiterpene lactones (diversolides A, D, F and G, 2-5) isolated from the roots of Ferula diversivittata were studied for their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). All of the tested compounds were active against EBV-EA activation. Among these compounds diversin (IC(50): 7.7) exhibited the strongest inhibitory effect and was selected to examine its effects on in vivo two-stage mouse skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA) as initiator and TPA as promoter. Treatment with compound 1 (85nmol) along with DMBA/TPA inhibited papilloma formation up to week 7 and the percentage of papilloma bearers was approximately 93.3% at week 20. The average number of papillomas formed per mouse was only 5.5 even at week 20. The results of the present investigation indicated that diversin might be valuable as a potent cancer chemopreventive agent and its potency was comparable with those of curcumin and quercetin, two well-known cancer chemopreventive agents.

Authors+Show Affiliations

Department of Pharmacognosy, Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, (MUMS), P.O. Box: 91775-1365, Mashhad, Iran. Iranshahim@mums.ac.irNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19577457

Citation

Iranshahi, M, et al. "Cancer Chemopreventive Activity of Diversin From Ferula Diversivittata in Vitro and in Vivo." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 17, no. 3-4, 2010, pp. 269-73.
Iranshahi M, Sahebkar A, Hosseini ST, et al. Cancer chemopreventive activity of diversin from Ferula diversivittata in vitro and in vivo. Phytomedicine. 2010;17(3-4):269-73.
Iranshahi, M., Sahebkar, A., Hosseini, S. T., Takasaki, M., Konoshima, T., & Tokuda, H. (2010). Cancer chemopreventive activity of diversin from Ferula diversivittata in vitro and in vivo. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 17(3-4), 269-73. https://doi.org/10.1016/j.phymed.2009.05.020
Iranshahi M, et al. Cancer Chemopreventive Activity of Diversin From Ferula Diversivittata in Vitro and in Vivo. Phytomedicine. 2010;17(3-4):269-73. PubMed PMID: 19577457.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cancer chemopreventive activity of diversin from Ferula diversivittata in vitro and in vivo. AU - Iranshahi,M, AU - Sahebkar,A, AU - Hosseini,S T, AU - Takasaki,M, AU - Konoshima,T, AU - Tokuda,H, Y1 - 2009/07/03/ PY - 2009/03/16/received PY - 2009/05/04/revised PY - 2009/05/29/accepted PY - 2009/7/7/entrez PY - 2009/7/7/pubmed PY - 2010/8/31/medline SP - 269 EP - 73 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 17 IS - 3-4 N2 - A prenylated coumarin (diversin, 1) together with four new sesquiterpene lactones (diversolides A, D, F and G, 2-5) isolated from the roots of Ferula diversivittata were studied for their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). All of the tested compounds were active against EBV-EA activation. Among these compounds diversin (IC(50): 7.7) exhibited the strongest inhibitory effect and was selected to examine its effects on in vivo two-stage mouse skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA) as initiator and TPA as promoter. Treatment with compound 1 (85nmol) along with DMBA/TPA inhibited papilloma formation up to week 7 and the percentage of papilloma bearers was approximately 93.3% at week 20. The average number of papillomas formed per mouse was only 5.5 even at week 20. The results of the present investigation indicated that diversin might be valuable as a potent cancer chemopreventive agent and its potency was comparable with those of curcumin and quercetin, two well-known cancer chemopreventive agents. SN - 1618-095X UR - https://www.unboundmedicine.com/medline/citation/19577457/Cancer_chemopreventive_activity_of_diversin_from_Ferula_diversivittata_in_vitro_and_in_vivo_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(09)00156-1 DB - PRIME DP - Unbound Medicine ER -