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Oxidative stress in the pathogenesis of psoriasis.
Free Radic Biol Med. 2009 Oct 01; 47(7):891-905.FR

Abstract

Psoriasis is a chronic immune-mediated hyperproliferative inflammatory skin disease in which a cytokine network concept is well established. Skin is a major target of oxidative stress mainly due to reactive oxygen species (ROS) originating from the environment and skin metabolism itself. Although endogenous antioxidants attenuate the harmful effects of ROS, increased or prolonged presence of free radicals can override ROS defense mechanisms and mediate numerous cellular responses that contribute to the development of a variety of skin disorders, including psoriasis. Regarding psoriasis, antioxidant strategies have proven to be beneficial therapeutics. The cellular signaling pathways such as mitogen-activated protein kinase/activator protein 1, nuclear factor kappaB, and Janus kinase-signal transducers and activators of transcription are known to be redox sensitive and proven to be involved in the progress of psoriasis. This review summarizes the current knowledge of the role of the redox system in regulating these signaling pathways related to the pathogenesis of psoriasis.

Authors+Show Affiliations

Department of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19577640

Citation

Zhou, Qiang, et al. "Oxidative Stress in the Pathogenesis of Psoriasis." Free Radical Biology & Medicine, vol. 47, no. 7, 2009, pp. 891-905.
Zhou Q, Mrowietz U, Rostami-Yazdi M. Oxidative stress in the pathogenesis of psoriasis. Free Radic Biol Med. 2009;47(7):891-905.
Zhou, Q., Mrowietz, U., & Rostami-Yazdi, M. (2009). Oxidative stress in the pathogenesis of psoriasis. Free Radical Biology & Medicine, 47(7), 891-905. https://doi.org/10.1016/j.freeradbiomed.2009.06.033
Zhou Q, Mrowietz U, Rostami-Yazdi M. Oxidative Stress in the Pathogenesis of Psoriasis. Free Radic Biol Med. 2009 Oct 1;47(7):891-905. PubMed PMID: 19577640.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress in the pathogenesis of psoriasis. AU - Zhou,Qiang, AU - Mrowietz,Ulrich, AU - Rostami-Yazdi,Martin, Y1 - 2009/07/03/ PY - 2009/01/23/received PY - 2009/05/29/revised PY - 2009/06/26/accepted PY - 2009/7/7/entrez PY - 2009/7/7/pubmed PY - 2010/1/27/medline SP - 891 EP - 905 JF - Free radical biology & medicine JO - Free Radic Biol Med VL - 47 IS - 7 N2 - Psoriasis is a chronic immune-mediated hyperproliferative inflammatory skin disease in which a cytokine network concept is well established. Skin is a major target of oxidative stress mainly due to reactive oxygen species (ROS) originating from the environment and skin metabolism itself. Although endogenous antioxidants attenuate the harmful effects of ROS, increased or prolonged presence of free radicals can override ROS defense mechanisms and mediate numerous cellular responses that contribute to the development of a variety of skin disorders, including psoriasis. Regarding psoriasis, antioxidant strategies have proven to be beneficial therapeutics. The cellular signaling pathways such as mitogen-activated protein kinase/activator protein 1, nuclear factor kappaB, and Janus kinase-signal transducers and activators of transcription are known to be redox sensitive and proven to be involved in the progress of psoriasis. This review summarizes the current knowledge of the role of the redox system in regulating these signaling pathways related to the pathogenesis of psoriasis. SN - 1873-4596 UR - https://www.unboundmedicine.com/medline/citation/19577640/Oxidative_stress_in_the_pathogenesis_of_psoriasis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0891-5849(09)00400-6 DB - PRIME DP - Unbound Medicine ER -