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Biomarkers of premature atherosclerosis.
Trends Mol Med 2009; 15(7):323-32TM

Abstract

C-reactive protein (CRP) is an acute phase protein and a biochemical marker with important prognostic value for cardiovascular events. Interleukins IL-1 and IL-6 are implicated in the pathogenesis of atherosclerosis and are associated with CRP. Apolipoproteins ApoA-I and ApoB are the main lipid metabolic markers implicated in the development and progression of atherosclerosis. Fibrinogen has also been proposed to be a major independent risk factor for cardiovascular events. Because premature atherosclerosis precedes the development of cardiovascular disease, identification of the associated biomarkers is of great importance. However, further studies will be needed to determine whether or not these markers are useful predictors of future cardiovascular events. Here, we review the roles of specific biomarkers that have been implicated in premature atherosclerosis.

Authors+Show Affiliations

Athens University Medical School, 1(st) Cardiology Department, Hippokration Hospital, Athens, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19577961

Citation

Kampoli, Anna-Maria, et al. "Biomarkers of Premature Atherosclerosis." Trends in Molecular Medicine, vol. 15, no. 7, 2009, pp. 323-32.
Kampoli AM, Tousoulis D, Antoniades C, et al. Biomarkers of premature atherosclerosis. Trends Mol Med. 2009;15(7):323-32.
Kampoli, A. M., Tousoulis, D., Antoniades, C., Siasos, G., & Stefanadis, C. (2009). Biomarkers of premature atherosclerosis. Trends in Molecular Medicine, 15(7), pp. 323-32. doi:10.1016/j.molmed.2009.06.001.
Kampoli AM, et al. Biomarkers of Premature Atherosclerosis. Trends Mol Med. 2009;15(7):323-32. PubMed PMID: 19577961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biomarkers of premature atherosclerosis. AU - Kampoli,Anna-Maria, AU - Tousoulis,Dimitris, AU - Antoniades,Charalambos, AU - Siasos,Gerasimos, AU - Stefanadis,Christodoulos, Y1 - 2009/07/03/ PY - 2008/03/06/received PY - 2009/05/07/revised PY - 2009/06/01/accepted PY - 2009/7/7/entrez PY - 2009/7/7/pubmed PY - 2009/9/15/medline SP - 323 EP - 32 JF - Trends in molecular medicine JO - Trends Mol Med VL - 15 IS - 7 N2 - C-reactive protein (CRP) is an acute phase protein and a biochemical marker with important prognostic value for cardiovascular events. Interleukins IL-1 and IL-6 are implicated in the pathogenesis of atherosclerosis and are associated with CRP. Apolipoproteins ApoA-I and ApoB are the main lipid metabolic markers implicated in the development and progression of atherosclerosis. Fibrinogen has also been proposed to be a major independent risk factor for cardiovascular events. Because premature atherosclerosis precedes the development of cardiovascular disease, identification of the associated biomarkers is of great importance. However, further studies will be needed to determine whether or not these markers are useful predictors of future cardiovascular events. Here, we review the roles of specific biomarkers that have been implicated in premature atherosclerosis. SN - 1471-499X UR - https://www.unboundmedicine.com/medline/citation/19577961/Biomarkers_of_premature_atherosclerosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1471-4914(09)00101-4 DB - PRIME DP - Unbound Medicine ER -