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Cigarette smoking and risk of prostate cancer among Singapore Chinese.
Cancer Causes Control. 2009 Dec; 20(10):1967-74.CC

Abstract

Prospective epidemiologic studies conducted in Western populations support an association between current smoking and aggressive subtypes of prostate cancer. In Singapore, where prostate-specific antigen is not used for population-wide screening, prostate cancer incidence has tripled within the past two decades. Using Cox regression methods, we examined the relationship between smoking and prostate cancer established between 1993 and 1998 in a cohort of 27,293 Singapore Chinese men. As of December 2006, 250 incident prostate cancer cases were diagnosed. In our cohort, 42.2% reported never smoking cigarettes, 15.7% quit over 5 years ago (long-term former), 5.7% quit within the past 5 years (recent former), and 36.4% were current smokers. From multivariable models, we observed no association with smoking status, age at starting to smoke, years smoked, or number of cigarettes per day. Among recent former and current smokers combined, we observed a small positive association for earlier age at starting to smoke that was somewhat stronger for nonadvanced disease (hazard ratio = 1.63, 95% confidence interval: 0.85, 3.12, for <15 years versus nonsmokers). Smoking was not a major risk factor for prostate cancer in our Singapore Chinese cohort, a traditionally low risk population with parallel increases in incidence and mortality.

Authors+Show Affiliations

Department of Environmental and Radiological Health Sciences, Colorado State University, 1681 Campus Delivery, Fort Collins, CO 80523-1681, USA. Lesley.Butler@colostate.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19579052

Citation

Butler, Lesley M., et al. "Cigarette Smoking and Risk of Prostate Cancer Among Singapore Chinese." Cancer Causes & Control : CCC, vol. 20, no. 10, 2009, pp. 1967-74.
Butler LM, Wang R, Wong AS, et al. Cigarette smoking and risk of prostate cancer among Singapore Chinese. Cancer Causes Control. 2009;20(10):1967-74.
Butler, L. M., Wang, R., Wong, A. S., Koh, W. P., & Yu, M. C. (2009). Cigarette smoking and risk of prostate cancer among Singapore Chinese. Cancer Causes & Control : CCC, 20(10), 1967-74. https://doi.org/10.1007/s10552-009-9391-2
Butler LM, et al. Cigarette Smoking and Risk of Prostate Cancer Among Singapore Chinese. Cancer Causes Control. 2009;20(10):1967-74. PubMed PMID: 19579052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cigarette smoking and risk of prostate cancer among Singapore Chinese. AU - Butler,Lesley M, AU - Wang,Renwei, AU - Wong,Alvin S, AU - Koh,Woon-Puay, AU - Yu,Mimi C, PY - 2009/01/28/received PY - 2009/06/18/accepted PY - 2009/7/7/entrez PY - 2009/7/7/pubmed PY - 2011/6/22/medline SP - 1967 EP - 74 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 20 IS - 10 N2 - Prospective epidemiologic studies conducted in Western populations support an association between current smoking and aggressive subtypes of prostate cancer. In Singapore, where prostate-specific antigen is not used for population-wide screening, prostate cancer incidence has tripled within the past two decades. Using Cox regression methods, we examined the relationship between smoking and prostate cancer established between 1993 and 1998 in a cohort of 27,293 Singapore Chinese men. As of December 2006, 250 incident prostate cancer cases were diagnosed. In our cohort, 42.2% reported never smoking cigarettes, 15.7% quit over 5 years ago (long-term former), 5.7% quit within the past 5 years (recent former), and 36.4% were current smokers. From multivariable models, we observed no association with smoking status, age at starting to smoke, years smoked, or number of cigarettes per day. Among recent former and current smokers combined, we observed a small positive association for earlier age at starting to smoke that was somewhat stronger for nonadvanced disease (hazard ratio = 1.63, 95% confidence interval: 0.85, 3.12, for <15 years versus nonsmokers). Smoking was not a major risk factor for prostate cancer in our Singapore Chinese cohort, a traditionally low risk population with parallel increases in incidence and mortality. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/19579052/Cigarette_smoking_and_risk_of_prostate_cancer_among_Singapore_Chinese_ DB - PRIME DP - Unbound Medicine ER -