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Longitudinal myelitis associated with yellow fever vaccination.
J Neurovirol. 2009 Jul; 15(4):348-50.JN

Abstract

Severe adverse reaction to yellow fever (YF) vaccine includes the yellow fever vaccine-associated neurotropic disease. This terminology includes postvaccinal encephalitis, acute disseminated encephalomyelitis, and Guillain-Barré syndrome. The objective of this communication is to report a patient who received a YF vaccine in Argentina and subsequently developed longitudinal myelitis with a symptom that had previously gone unreported in the literature. A 56-year-old man began with progressive paraparesia, urinary retention, and constipation 48 h previous to admission. The patient received YF vaccine 45 days prior to the onset of the symptoms. There was no history of other immunization or relevant condition. MR of the spine showed longitudinal intramedullary hyperintense signal (D5-12) without gadolinium enhancement. A high concentration of YFV-specific IgM vaccine antibody was found in the cerebrospinal fluid (CSF). Serological tests for other flavivirus were negative. A diagnosis of longitudinal myelitis without encephalitis associated with YF vaccine was performed and symptoms improved 5 days later. This is the first report dealing with longitudinal myelitis as a serious adverse event associated with YF vaccination in which confirmation of the presence of antibodies in CSF was found. To date, it is also the first report with serological confirmation in Argentina and in South America. We consider that the present investigation will raise awareness in the region in the reporting of adverse events related to YF vaccine and improve our knowledge of adverse reactions to the vaccine.

Authors+Show Affiliations

Department of Neurology Department, Hospital Italiano Buenos Aires, Buenos Aires, Argentina. marcelo.chaves@hospitalitaliano.org.arNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19579072

Citation

Chaves, M, et al. "Longitudinal Myelitis Associated With Yellow Fever Vaccination." Journal of Neurovirology, vol. 15, no. 4, 2009, pp. 348-50.
Chaves M, Riccio P, Patrucco L, et al. Longitudinal myelitis associated with yellow fever vaccination. J Neurovirol. 2009;15(4):348-50.
Chaves, M., Riccio, P., Patrucco, L., Rojas, J. I., & Cristiano, E. (2009). Longitudinal myelitis associated with yellow fever vaccination. Journal of Neurovirology, 15(4), 348-50. https://doi.org/10.1080/13550280903062805
Chaves M, et al. Longitudinal Myelitis Associated With Yellow Fever Vaccination. J Neurovirol. 2009;15(4):348-50. PubMed PMID: 19579072.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Longitudinal myelitis associated with yellow fever vaccination. AU - Chaves,M, AU - Riccio,P, AU - Patrucco,L, AU - Rojas,J I, AU - Cristiano,E, PY - 2009/7/7/entrez PY - 2009/7/7/pubmed PY - 2010/10/13/medline SP - 348 EP - 50 JF - Journal of neurovirology JO - J Neurovirol VL - 15 IS - 4 N2 - Severe adverse reaction to yellow fever (YF) vaccine includes the yellow fever vaccine-associated neurotropic disease. This terminology includes postvaccinal encephalitis, acute disseminated encephalomyelitis, and Guillain-Barré syndrome. The objective of this communication is to report a patient who received a YF vaccine in Argentina and subsequently developed longitudinal myelitis with a symptom that had previously gone unreported in the literature. A 56-year-old man began with progressive paraparesia, urinary retention, and constipation 48 h previous to admission. The patient received YF vaccine 45 days prior to the onset of the symptoms. There was no history of other immunization or relevant condition. MR of the spine showed longitudinal intramedullary hyperintense signal (D5-12) without gadolinium enhancement. A high concentration of YFV-specific IgM vaccine antibody was found in the cerebrospinal fluid (CSF). Serological tests for other flavivirus were negative. A diagnosis of longitudinal myelitis without encephalitis associated with YF vaccine was performed and symptoms improved 5 days later. This is the first report dealing with longitudinal myelitis as a serious adverse event associated with YF vaccination in which confirmation of the presence of antibodies in CSF was found. To date, it is also the first report with serological confirmation in Argentina and in South America. We consider that the present investigation will raise awareness in the region in the reporting of adverse events related to YF vaccine and improve our knowledge of adverse reactions to the vaccine. SN - 1538-2443 UR - https://www.unboundmedicine.com/medline/citation/19579072/Longitudinal_myelitis_associated_with_yellow_fever_vaccination_ L2 - https://dx.doi.org/10.1080/13550280903062805 DB - PRIME DP - Unbound Medicine ER -