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TRP channel antagonists for pain--opportunities beyond TRPV1.
Curr Opin Investig Drugs. 2009 Jul; 10(7):655-63.CO

Abstract

There is emerging evidence that transient receptor potential (TRP) ion channels expressed in sensory neurons are important for the transduction of chemical, thermal and mechanical signals. Increasing research efforts are directed at understanding the roles of sensory TRP channels in acute and chronic pain. Studies using RNAi techniques to reduce the levels of individual TRP channels or genetically modified mice lacking specific channels are being complemented with pharmacological studies using newly discovered investigational compounds. These studies are providing evidence that drugs that interfere with the function of TRPA1, TRPM8, TRPV4 or TRPV3 may be useful in treating pain.

Authors+Show Affiliations

Wolfson Centre for Age Related Diseases, King's College London, Wolfson Wing, Hodgkin Building, Guy's Campus, London, SE1 1UL, UK. stuart.bevan@kcl.ac.ukNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19579171

Citation

Bevan, Stuart, and David A. Andersson. "TRP Channel Antagonists for Pain--opportunities Beyond TRPV1." Current Opinion in Investigational Drugs (London, England : 2000), vol. 10, no. 7, 2009, pp. 655-63.
Bevan S, Andersson DA. TRP channel antagonists for pain--opportunities beyond TRPV1. Curr Opin Investig Drugs. 2009;10(7):655-63.
Bevan, S., & Andersson, D. A. (2009). TRP channel antagonists for pain--opportunities beyond TRPV1. Current Opinion in Investigational Drugs (London, England : 2000), 10(7), 655-63.
Bevan S, Andersson DA. TRP Channel Antagonists for Pain--opportunities Beyond TRPV1. Curr Opin Investig Drugs. 2009;10(7):655-63. PubMed PMID: 19579171.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - TRP channel antagonists for pain--opportunities beyond TRPV1. AU - Bevan,Stuart, AU - Andersson,David A, PY - 2009/7/7/entrez PY - 2009/7/7/pubmed PY - 2009/9/23/medline SP - 655 EP - 63 JF - Current opinion in investigational drugs (London, England : 2000) JO - Curr Opin Investig Drugs VL - 10 IS - 7 N2 - There is emerging evidence that transient receptor potential (TRP) ion channels expressed in sensory neurons are important for the transduction of chemical, thermal and mechanical signals. Increasing research efforts are directed at understanding the roles of sensory TRP channels in acute and chronic pain. Studies using RNAi techniques to reduce the levels of individual TRP channels or genetically modified mice lacking specific channels are being complemented with pharmacological studies using newly discovered investigational compounds. These studies are providing evidence that drugs that interfere with the function of TRPA1, TRPM8, TRPV4 or TRPV3 may be useful in treating pain. SN - 2040-3429 UR - https://www.unboundmedicine.com/medline/citation/19579171/TRP_channel_antagonists_for_pain__opportunities_beyond_TRPV1_ L2 - https://medlineplus.gov/pain.html DB - PRIME DP - Unbound Medicine ER -