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Mineralization density distribution of postmenopausal osteoporotic bone is restored to normal after long-term alendronate treatment: qBEI and sSAXS data from the fracture intervention trial long-term extension (FLEX).
J Bone Miner Res. 2010 Jan; 25(1):48-55.JB

Abstract

Long-term treatment studies showed that the therapeutic effects of alendronate (ALN) were sustained over a 10-year treatment period. However, data on the effects on intrinsic bone material properties by long-term reduction of bone turnover are still sparse. We analyzed transiliacal bone biopsies of a subgroup of 30 Fracture Intervention Trial Long-Term Extension (FLEX) participants (n = 6 were treated for 10 years with ALN at dose of 10 mg/day, n = 10 were treated for 10 years with ALN at dose of 5 mg/day, and n = 14 were treated for 5 years with ALN plus a further 5 years with placebo) by quantitative backscattered electron imaging (qBEI) and scanning small-angle X-ray scattering (sSAXS) to determine the bone mineralization density distribution (BMDD) and the mineral particle thickness parameter T. BMDD data from these FLEX participants were compared with those from a previously published healthy population (n = 52). Compared with 5 years of ALN plus 5 years of placebo 10 years of ALN treatment (independent of the dose given) did not produce any difference in any of the BMDD parameters: The weighted mean (Ca(mean)), the typical calcium concentration (Ca(peak)), the heterogeneity of mineralization (Ca(width)), the percentage of low-mineralized bone areas (Ca(low)), and the portion of highly mineralized areas (Ca(high)) were not different for the patients who continued ALN from those who stopped ALN after 5 years. Moreover, no significant differences for any of the BMDD parameters between the FLEX participants and the healthy population could be observed. In none of the investigated cases were abnormally high mineralization or changes in mineral particle thickness observed (Ca(high) and T were both in the normal range). The findings of this study support the recommendation that antiresorptive treatment with ALN should be maintained for 5 years. Even with longer treatment durations of up to 10 years, though, no negative effects on bone matrix mineralization were observed.

Authors+Show Affiliations

Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 4th Medical Department, Hanusch Hospital, Vienna, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19580465

Citation

Roschger, P, et al. "Mineralization Density Distribution of Postmenopausal Osteoporotic Bone Is Restored to Normal After Long-term Alendronate Treatment: qBEI and sSAXS Data From the Fracture Intervention Trial Long-term Extension (FLEX)." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 25, no. 1, 2010, pp. 48-55.
Roschger P, Lombardi A, Misof BM, et al. Mineralization density distribution of postmenopausal osteoporotic bone is restored to normal after long-term alendronate treatment: qBEI and sSAXS data from the fracture intervention trial long-term extension (FLEX). J Bone Miner Res. 2010;25(1):48-55.
Roschger, P., Lombardi, A., Misof, B. M., Maier, G., Fratzl-Zelman, N., Fratzl, P., & Klaushofer, K. (2010). Mineralization density distribution of postmenopausal osteoporotic bone is restored to normal after long-term alendronate treatment: qBEI and sSAXS data from the fracture intervention trial long-term extension (FLEX). Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 25(1), 48-55. https://doi.org/10.1359/jbmr.090702
Roschger P, et al. Mineralization Density Distribution of Postmenopausal Osteoporotic Bone Is Restored to Normal After Long-term Alendronate Treatment: qBEI and sSAXS Data From the Fracture Intervention Trial Long-term Extension (FLEX). J Bone Miner Res. 2010;25(1):48-55. PubMed PMID: 19580465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mineralization density distribution of postmenopausal osteoporotic bone is restored to normal after long-term alendronate treatment: qBEI and sSAXS data from the fracture intervention trial long-term extension (FLEX). AU - Roschger,P, AU - Lombardi,A, AU - Misof,B M, AU - Maier,G, AU - Fratzl-Zelman,N, AU - Fratzl,P, AU - Klaushofer,K, PY - 2009/7/8/entrez PY - 2009/7/8/pubmed PY - 2010/7/9/medline SP - 48 EP - 55 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J Bone Miner Res VL - 25 IS - 1 N2 - Long-term treatment studies showed that the therapeutic effects of alendronate (ALN) were sustained over a 10-year treatment period. However, data on the effects on intrinsic bone material properties by long-term reduction of bone turnover are still sparse. We analyzed transiliacal bone biopsies of a subgroup of 30 Fracture Intervention Trial Long-Term Extension (FLEX) participants (n = 6 were treated for 10 years with ALN at dose of 10 mg/day, n = 10 were treated for 10 years with ALN at dose of 5 mg/day, and n = 14 were treated for 5 years with ALN plus a further 5 years with placebo) by quantitative backscattered electron imaging (qBEI) and scanning small-angle X-ray scattering (sSAXS) to determine the bone mineralization density distribution (BMDD) and the mineral particle thickness parameter T. BMDD data from these FLEX participants were compared with those from a previously published healthy population (n = 52). Compared with 5 years of ALN plus 5 years of placebo 10 years of ALN treatment (independent of the dose given) did not produce any difference in any of the BMDD parameters: The weighted mean (Ca(mean)), the typical calcium concentration (Ca(peak)), the heterogeneity of mineralization (Ca(width)), the percentage of low-mineralized bone areas (Ca(low)), and the portion of highly mineralized areas (Ca(high)) were not different for the patients who continued ALN from those who stopped ALN after 5 years. Moreover, no significant differences for any of the BMDD parameters between the FLEX participants and the healthy population could be observed. In none of the investigated cases were abnormally high mineralization or changes in mineral particle thickness observed (Ca(high) and T were both in the normal range). The findings of this study support the recommendation that antiresorptive treatment with ALN should be maintained for 5 years. Even with longer treatment durations of up to 10 years, though, no negative effects on bone matrix mineralization were observed. SN - 1523-4681 UR - https://www.unboundmedicine.com/medline/citation/19580465/Mineralization_density_distribution_of_postmenopausal_osteoporotic_bone_is_restored_to_normal_after_long_term_alendronate_treatment:_qBEI_and_sSAXS_data_from_the_fracture_intervention_trial_long_term_extension__FLEX__ L2 - https://doi.org/10.1359/jbmr.090702 DB - PRIME DP - Unbound Medicine ER -