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Induction of heat shock protein 70 reduces the alteration of striatal electrical activity caused by mitochondrial impairment.
Neuroscience. 2009 Oct 20; 163(3):735-40.N

Abstract

Since mild thermal stress seems to exert neuroprotection via induction of heat-shock protein 70 kDa (hsp70), we tested whether hsp70 would preserve striatal bioelectrical activity under conditions of mitochondrial impairment. Corticostriatal slices from rats that had undergone mild thermal stress were exposed to either rotenone or 3-nitropropionic acid (3-NP), that selectively inhibits mitochondrial complex I and complex II, respectively. Rotenone is utilized to obtain an experimental model of Parkinson's disease while 3-NP replicates Huntington's disease phenotype in experimental animals. The cerebral hsp70 increase did not alter field potential amplitude of the slices but partially protected them against rotenone-induced neurotoxicity. Similarly, induction of hsp70 had also a partial neuroprotective effect on the neurotoxicity caused by 3-NP on striatal field potential. Since rotenone and 3-NP treatments mimic the mitochondrial impairment and oxidative stress that contribute to development of Parkinson's disease and Huntington's disease, these data suggest that induction of hsp70 might represent a possible neuroprotective mechanism against the pathophysiological chain of events implicated in these neurodegenerative disorders.

Authors+Show Affiliations

Dipartimento di Specialità Medico-Chirurgiche e Sanità Pubblica, Clinica Neurologica, Università degli Studi di Perugia, Via Enrico dal Pozzo, 06126 Perugia, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19580850

Citation

Tantucci, M, et al. "Induction of Heat Shock Protein 70 Reduces the Alteration of Striatal Electrical Activity Caused By Mitochondrial Impairment." Neuroscience, vol. 163, no. 3, 2009, pp. 735-40.
Tantucci M, Mariucci G, Taha E, et al. Induction of heat shock protein 70 reduces the alteration of striatal electrical activity caused by mitochondrial impairment. Neuroscience. 2009;163(3):735-40.
Tantucci, M., Mariucci, G., Taha, E., Spaccatini, C., Tozzi, A., Luchetti, E., Calabresi, P., & Ambrosini, M. V. (2009). Induction of heat shock protein 70 reduces the alteration of striatal electrical activity caused by mitochondrial impairment. Neuroscience, 163(3), 735-40. https://doi.org/10.1016/j.neuroscience.2009.06.070
Tantucci M, et al. Induction of Heat Shock Protein 70 Reduces the Alteration of Striatal Electrical Activity Caused By Mitochondrial Impairment. Neuroscience. 2009 Oct 20;163(3):735-40. PubMed PMID: 19580850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Induction of heat shock protein 70 reduces the alteration of striatal electrical activity caused by mitochondrial impairment. AU - Tantucci,M, AU - Mariucci,G, AU - Taha,E, AU - Spaccatini,C, AU - Tozzi,A, AU - Luchetti,E, AU - Calabresi,P, AU - Ambrosini,M V, Y1 - 2009/07/04/ PY - 2009/05/11/received PY - 2009/06/26/revised PY - 2009/06/29/accepted PY - 2009/7/8/entrez PY - 2009/7/8/pubmed PY - 2010/1/15/medline SP - 735 EP - 40 JF - Neuroscience JO - Neuroscience VL - 163 IS - 3 N2 - Since mild thermal stress seems to exert neuroprotection via induction of heat-shock protein 70 kDa (hsp70), we tested whether hsp70 would preserve striatal bioelectrical activity under conditions of mitochondrial impairment. Corticostriatal slices from rats that had undergone mild thermal stress were exposed to either rotenone or 3-nitropropionic acid (3-NP), that selectively inhibits mitochondrial complex I and complex II, respectively. Rotenone is utilized to obtain an experimental model of Parkinson's disease while 3-NP replicates Huntington's disease phenotype in experimental animals. The cerebral hsp70 increase did not alter field potential amplitude of the slices but partially protected them against rotenone-induced neurotoxicity. Similarly, induction of hsp70 had also a partial neuroprotective effect on the neurotoxicity caused by 3-NP on striatal field potential. Since rotenone and 3-NP treatments mimic the mitochondrial impairment and oxidative stress that contribute to development of Parkinson's disease and Huntington's disease, these data suggest that induction of hsp70 might represent a possible neuroprotective mechanism against the pathophysiological chain of events implicated in these neurodegenerative disorders. SN - 1873-7544 UR - https://www.unboundmedicine.com/medline/citation/19580850/Induction_of_heat_shock_protein_70_reduces_the_alteration_of_striatal_electrical_activity_caused_by_mitochondrial_impairment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(09)01120-8 DB - PRIME DP - Unbound Medicine ER -