Tags

Type your tag names separated by a space and hit enter

Radiation treatment interruptions greater than one week and low hemoglobin levels (12 g/dL) are predictors of local regional failure after definitive concurrent chemotherapy and intensity-modulated radiation therapy for squamous cell carcinoma of the head and neck.
Am J Clin Oncol. 2009 Dec; 32(6):587-91.AJ

Abstract

PURPOSE

To determine whether baseline hemoglobin level and radiation treatment interruptions predict for loco-regional failure after intensity-modulated radiation therapy (IMRT) with concurrent chemotherapy for definitive treatment of squamous cell carcinoma of the head and neck (SCCHN).

METHODS

This retrospective review identified 78 consecutive patients treated with definitive concurrent chemoradiation for SCCHN. Patients were treated with IMRT to 70 Gy in 35 daily fractions to the high-dose target volume and 56 Gy to the elective target volume.

RESULTS

Median age of the cohort was 62 (37-81). Median follow-up was 12 months. Tumor sites included: oropharynx (54%), larynx (36%), oral cavity (5%), and hypopharynx (5%). Fifteen of 78 patients (19%) experienced loco-regional failure. These included: 6 primary site failures, 5 regional failures, and 4 failures in both the primary site and regional lymph nodes. All but one failure occurred in the high-dose target volume. Only duration of radiation treatment and baseline hemoglobin levels were significant predictors of local control. Loco-regional failure occurred in 6 of 13 patients (46%) with radiation treatment interruptions (>1 week) versus 9 of 65 patients (14%) completing radiation therapy without interruption (P = 0.0148). Loco-regional failure occurred in 7 of 19 patients (37%) whose pretreatment hemoglobin level was <12 g/dL compared with 8 of 59 patients (14%) with hemoglobin levels > or = 12 (P = 0.042).

CONCLUSION

Overall radiation treatment time and pretreatment hemoglobin level were significant predictors for loco-regional failure after definitive concurrent chemotherapy and IMRT for SCCHN.

Authors+Show Affiliations

Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, New York, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19581794

Citation

McCloskey, Susan A., et al. "Radiation Treatment Interruptions Greater Than One Week and Low Hemoglobin Levels (12 g/dL) Are Predictors of Local Regional Failure After Definitive Concurrent Chemotherapy and Intensity-modulated Radiation Therapy for Squamous Cell Carcinoma of the Head and Neck." American Journal of Clinical Oncology, vol. 32, no. 6, 2009, pp. 587-91.
McCloskey SA, Jaggernauth W, Rigual NR, et al. Radiation treatment interruptions greater than one week and low hemoglobin levels (12 g/dL) are predictors of local regional failure after definitive concurrent chemotherapy and intensity-modulated radiation therapy for squamous cell carcinoma of the head and neck. Am J Clin Oncol. 2009;32(6):587-91.
McCloskey, S. A., Jaggernauth, W., Rigual, N. R., Hicks, W. L., Popat, S. R., Sullivan, M., Mashtare, T. L., Khan, M. K., Loree, T. R., & Singh, A. K. (2009). Radiation treatment interruptions greater than one week and low hemoglobin levels (12 g/dL) are predictors of local regional failure after definitive concurrent chemotherapy and intensity-modulated radiation therapy for squamous cell carcinoma of the head and neck. American Journal of Clinical Oncology, 32(6), 587-91. https://doi.org/10.1097/COC.0b013e3181967dd0
McCloskey SA, et al. Radiation Treatment Interruptions Greater Than One Week and Low Hemoglobin Levels (12 g/dL) Are Predictors of Local Regional Failure After Definitive Concurrent Chemotherapy and Intensity-modulated Radiation Therapy for Squamous Cell Carcinoma of the Head and Neck. Am J Clin Oncol. 2009;32(6):587-91. PubMed PMID: 19581794.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Radiation treatment interruptions greater than one week and low hemoglobin levels (12 g/dL) are predictors of local regional failure after definitive concurrent chemotherapy and intensity-modulated radiation therapy for squamous cell carcinoma of the head and neck. AU - McCloskey,Susan A, AU - Jaggernauth,Wainwright, AU - Rigual,Nestor R, AU - Hicks,Wesley L,Jr AU - Popat,Saurin R, AU - Sullivan,Maureen, AU - Mashtare,Terry L,Jr AU - Khan,Mohamed K, AU - Loree,Thom R, AU - Singh,Anurag K, PY - 2009/7/8/entrez PY - 2009/7/8/pubmed PY - 2009/12/23/medline SP - 587 EP - 91 JF - American journal of clinical oncology JO - Am J Clin Oncol VL - 32 IS - 6 N2 - PURPOSE: To determine whether baseline hemoglobin level and radiation treatment interruptions predict for loco-regional failure after intensity-modulated radiation therapy (IMRT) with concurrent chemotherapy for definitive treatment of squamous cell carcinoma of the head and neck (SCCHN). METHODS: This retrospective review identified 78 consecutive patients treated with definitive concurrent chemoradiation for SCCHN. Patients were treated with IMRT to 70 Gy in 35 daily fractions to the high-dose target volume and 56 Gy to the elective target volume. RESULTS: Median age of the cohort was 62 (37-81). Median follow-up was 12 months. Tumor sites included: oropharynx (54%), larynx (36%), oral cavity (5%), and hypopharynx (5%). Fifteen of 78 patients (19%) experienced loco-regional failure. These included: 6 primary site failures, 5 regional failures, and 4 failures in both the primary site and regional lymph nodes. All but one failure occurred in the high-dose target volume. Only duration of radiation treatment and baseline hemoglobin levels were significant predictors of local control. Loco-regional failure occurred in 6 of 13 patients (46%) with radiation treatment interruptions (>1 week) versus 9 of 65 patients (14%) completing radiation therapy without interruption (P = 0.0148). Loco-regional failure occurred in 7 of 19 patients (37%) whose pretreatment hemoglobin level was <12 g/dL compared with 8 of 59 patients (14%) with hemoglobin levels > or = 12 (P = 0.042). CONCLUSION: Overall radiation treatment time and pretreatment hemoglobin level were significant predictors for loco-regional failure after definitive concurrent chemotherapy and IMRT for SCCHN. SN - 1537-453X UR - https://www.unboundmedicine.com/medline/citation/19581794/Radiation_treatment_interruptions_greater_than_one_week_and_low_hemoglobin_levels__12_g/dL__are_predictors_of_local_regional_failure_after_definitive_concurrent_chemotherapy_and_intensity_modulated_radiation_therapy_for_squamous_cell_carcinoma_of_the_head_and_neck_ L2 - https://doi.org/10.1097/COC.0b013e3181967dd0 DB - PRIME DP - Unbound Medicine ER -