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An explorative study on quality of life and psychological and cognitive function in pediatric survivors of septic shock.
Pediatr Crit Care Med. 2009 Nov; 10(6):636-42.PC

Abstract

OBJECTIVE

To evaluate self-reported health-related quality of life, anxiety, depression, and cognitive function in pediatric septic shock survivors.

DESIGN

A retrospective cohort study.

SETTING

A 14-bed tertiary pediatric intensive care unit.

PATIENTS

Children aged >or=8 yrs at the time of the follow-up who were admitted between 1995 and 2004 for septic shock. Inotropic and or vasoconstrictive agents were administered to these patients for >or=24 hrs.

INTERVENTION

Health-related quality of life was assessed with the KIDSCREEN-52, anxiety with the State Trait Anxiety Inventory for Children, depression with the Children's Depression Inventory, and cognitive function with the cognitive scale of the TNO-AZL Children's Quality of Life Questionnaire Child Form.

MEASUREMENTS AND MAIN RESULTS

Fifty of 82 eligible pediatric septic shock survivors were evaluated. The median age of the children at pediatric intensive care unit admission was 4.2 yrs (range, 0.0-17.0 yrs); the median age at follow-up was 10.7 yrs (range, 8.0-20.4 yrs). Health-related quality of life and anxiety scores were comparable to the age-related Dutch norm population. Depression scores were significantly better than the norm population, whereas cognitive function was significantly lower than the norm population. We found that 44% of the children had cognitive scores <25% of the norm population. Young age at the time of pediatric intensive care unit admission was predictive of cognitive problems, and cognitive problems were associated with lower emotional function.

CONCLUSIONS

In this group of septic shock survivors, health-related quality of life, anxiety, and depression are equal to or slightly better than the age-related Dutch norm population. Cognitive function is decreased, especially in children admitted at younger ages. Follow-up studies with adequate neuropsychological testing are warranted to evaluate the association between septic shock, cognitive function, and risk factors for cognitive problems.

Authors+Show Affiliations

Psychosocial Department, Pediatric Intensive Care Unit, Emma Children's Hospital, Academic Medical Center, Amsterdam, Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19581821

Citation

Bronner, Madelon B., et al. "An Explorative Study On Quality of Life and Psychological and Cognitive Function in Pediatric Survivors of Septic Shock." Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, vol. 10, no. 6, 2009, pp. 636-42.
Bronner MB, Knoester H, Sol JJ, et al. An explorative study on quality of life and psychological and cognitive function in pediatric survivors of septic shock. Pediatr Crit Care Med. 2009;10(6):636-42.
Bronner, M. B., Knoester, H., Sol, J. J., Bos, A. P., Heymans, H. S., & Grootenhuis, M. A. (2009). An explorative study on quality of life and psychological and cognitive function in pediatric survivors of septic shock. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 10(6), 636-42. https://doi.org/10.1097/PCC.0b013e3181ae5c1a
Bronner MB, et al. An Explorative Study On Quality of Life and Psychological and Cognitive Function in Pediatric Survivors of Septic Shock. Pediatr Crit Care Med. 2009;10(6):636-42. PubMed PMID: 19581821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An explorative study on quality of life and psychological and cognitive function in pediatric survivors of septic shock. AU - Bronner,Madelon B, AU - Knoester,Hendrika, AU - Sol,Jeanine J, AU - Bos,Albert P, AU - Heymans,Hugo S A, AU - Grootenhuis,Martha A, PY - 2009/7/8/entrez PY - 2009/7/8/pubmed PY - 2010/1/27/medline SP - 636 EP - 42 JF - Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies JO - Pediatr Crit Care Med VL - 10 IS - 6 N2 - OBJECTIVE: To evaluate self-reported health-related quality of life, anxiety, depression, and cognitive function in pediatric septic shock survivors. DESIGN: A retrospective cohort study. SETTING: A 14-bed tertiary pediatric intensive care unit. PATIENTS: Children aged >or=8 yrs at the time of the follow-up who were admitted between 1995 and 2004 for septic shock. Inotropic and or vasoconstrictive agents were administered to these patients for >or=24 hrs. INTERVENTION: Health-related quality of life was assessed with the KIDSCREEN-52, anxiety with the State Trait Anxiety Inventory for Children, depression with the Children's Depression Inventory, and cognitive function with the cognitive scale of the TNO-AZL Children's Quality of Life Questionnaire Child Form. MEASUREMENTS AND MAIN RESULTS: Fifty of 82 eligible pediatric septic shock survivors were evaluated. The median age of the children at pediatric intensive care unit admission was 4.2 yrs (range, 0.0-17.0 yrs); the median age at follow-up was 10.7 yrs (range, 8.0-20.4 yrs). Health-related quality of life and anxiety scores were comparable to the age-related Dutch norm population. Depression scores were significantly better than the norm population, whereas cognitive function was significantly lower than the norm population. We found that 44% of the children had cognitive scores <25% of the norm population. Young age at the time of pediatric intensive care unit admission was predictive of cognitive problems, and cognitive problems were associated with lower emotional function. CONCLUSIONS: In this group of septic shock survivors, health-related quality of life, anxiety, and depression are equal to or slightly better than the age-related Dutch norm population. Cognitive function is decreased, especially in children admitted at younger ages. Follow-up studies with adequate neuropsychological testing are warranted to evaluate the association between septic shock, cognitive function, and risk factors for cognitive problems. SN - 1529-7535 UR - https://www.unboundmedicine.com/medline/citation/19581821/An_explorative_study_on_quality_of_life_and_psychological_and_cognitive_function_in_pediatric_survivors_of_septic_shock_ L2 - https://doi.org/10.1097/PCC.0b013e3181ae5c1a DB - PRIME DP - Unbound Medicine ER -