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Breast-feeding is associated with a reduced frequency of acute otitis media and high serum antibody levels against NTHi and outer membrane protein vaccine antigen candidate P6.

Abstract

Nontypeable Haemophilus influenzae (NTHi) causes acute otitis media (AOM) in infants. Breast-feeding protects against AOM and/or nasopharyngeal (NP) colonization; however, the mechanism of protection is incompletely understood. Children with AOM and healthy children were studied according to feeding status: breastfed,breast/formula fed, or formula fed. Cumulative episodes of AOM, ELISA titers of serum IgG antibodies to whole-cell NTHi and vaccine candidate outer membrane protein P6, bactericidal titers of serum and NP colonization by NTHi were assessed. A lower incidence of AOM was found in breast- versus formula-fed children. Levels of specific serum IgG antibody to NTHi and P6 were highest in breast-fed, intermediate in breast/formula fed, and lowest in formula-fed infants. Serum IgG antibody to P6 correlated with bactericidal activity against NTHi. Among children with AOM, the prevalence of NTHi in the NP was lower in breast- versus nonbreast-fed infants. We conclude that breast-feeding shows an association with higher levels of antibodies to NTHi and P6, suggesting that breast-feeding modulates the serum immune response to NTHi and P6. Higher serum IgG might facilitate protection against AOM and NP colonization in breast-fed children.

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    ,

    Department of Microbiology/Immunology, University of Rochester, Rochester, New York 14627, USA.

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    Source

    Pediatric research 66:5 2009 Nov pg 565-70

    MeSH

    Antibodies, Bacterial
    Bacterial Outer Membrane Proteins
    Breast Feeding
    Enzyme-Linked Immunosorbent Assay
    Haemophilus Infections
    Haemophilus Vaccines
    Haemophilus influenzae
    Humans
    Immunoglobulin G
    Infant
    Infant Formula
    Milk, Human
    Otitis Media

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    19581824

    Citation

    Sabirov, Albert, et al. "Breast-feeding Is Associated With a Reduced Frequency of Acute Otitis Media and High Serum Antibody Levels Against NTHi and Outer Membrane Protein Vaccine Antigen Candidate P6." Pediatric Research, vol. 66, no. 5, 2009, pp. 565-70.
    Sabirov A, Casey JR, Murphy TF, et al. Breast-feeding is associated with a reduced frequency of acute otitis media and high serum antibody levels against NTHi and outer membrane protein vaccine antigen candidate P6. Pediatr Res. 2009;66(5):565-70.
    Sabirov, A., Casey, J. R., Murphy, T. F., & Pichichero, M. E. (2009). Breast-feeding is associated with a reduced frequency of acute otitis media and high serum antibody levels against NTHi and outer membrane protein vaccine antigen candidate P6. Pediatric Research, 66(5), pp. 565-70. doi:10.1203/PDR.0b013e3181b4f8a6.
    Sabirov A, et al. Breast-feeding Is Associated With a Reduced Frequency of Acute Otitis Media and High Serum Antibody Levels Against NTHi and Outer Membrane Protein Vaccine Antigen Candidate P6. Pediatr Res. 2009;66(5):565-70. PubMed PMID: 19581824.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Breast-feeding is associated with a reduced frequency of acute otitis media and high serum antibody levels against NTHi and outer membrane protein vaccine antigen candidate P6. AU - Sabirov,Albert, AU - Casey,Janet R, AU - Murphy,Timothy F, AU - Pichichero,Michael E, PY - 2009/7/8/entrez PY - 2009/7/8/pubmed PY - 2010/1/13/medline SP - 565 EP - 70 JF - Pediatric research JO - Pediatr. Res. VL - 66 IS - 5 N2 - Nontypeable Haemophilus influenzae (NTHi) causes acute otitis media (AOM) in infants. Breast-feeding protects against AOM and/or nasopharyngeal (NP) colonization; however, the mechanism of protection is incompletely understood. Children with AOM and healthy children were studied according to feeding status: breastfed,breast/formula fed, or formula fed. Cumulative episodes of AOM, ELISA titers of serum IgG antibodies to whole-cell NTHi and vaccine candidate outer membrane protein P6, bactericidal titers of serum and NP colonization by NTHi were assessed. A lower incidence of AOM was found in breast- versus formula-fed children. Levels of specific serum IgG antibody to NTHi and P6 were highest in breast-fed, intermediate in breast/formula fed, and lowest in formula-fed infants. Serum IgG antibody to P6 correlated with bactericidal activity against NTHi. Among children with AOM, the prevalence of NTHi in the NP was lower in breast- versus nonbreast-fed infants. We conclude that breast-feeding shows an association with higher levels of antibodies to NTHi and P6, suggesting that breast-feeding modulates the serum immune response to NTHi and P6. Higher serum IgG might facilitate protection against AOM and NP colonization in breast-fed children. SN - 1530-0447 UR - https://www.unboundmedicine.com/medline/citation/19581824/full_citation L2 - http://dx.doi.org/10.1203/PDR.0b013e3181b4f8a6 DB - PRIME DP - Unbound Medicine ER -