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Inflammation and anaemia as predictors of cardiovascular mortality in hemodialysis patients.
Hippokratia. 2007 Jan; 11(1):39-43.H

Abstract

BACKGROUND

Cardiovascular diseases are the most common causes of death among hemodialysis (HD) patients, yet the risk factors for these events have not been well established. Our study objective was to determine predictors of cardiovascular mortality, considering the non-traditional/disease-related and treatment-related/ cardiovascular risk factor in HD patients.

MATERIAL AND METHODS

Disease-related cardiovascular risk factors, such as anaemia, calcium-phosphate disorders, nutrition-inflammation and treatment/dialysis-related cardiovascular risk factors such as HD dose, using the index Kt/V were analyzed in 214 patients on HD. Mortality was monitored prospectively over a two year period.

RESULTS

Fifty-three of the 214 HD patients died during the follow-up period and the main cause of death was cardiovascular events (56.6%), followed by infection/sepsis (26.4%). The patients who died were significantly older than those alive, had significantly lower serum levels of hemoglobin (Hb), albumin and Kt/V. Serum levels of calcium, C-reactive protein (CRP) and fibrinogen were significantly higher in patients who died during the follow-up period. Kaplan-Meier analysis showed that the all cause and cardiovascular mortality was considerably higher in patients with Hb<110 g/l, albumin <40 g/l, CRP>8 mg/l and spKt/V<1.2 (log rank, p=0.000/p=0.000, p=0.000/ p=0.001, p=0.000/p=0.000, p=0.000/p=0.000), respectively. No difference in cardiovascular mortality was observed between the fibrinogen <4 g/l> levels. High CRP, low Hb levels and low spKt/V were significant predictors of all-cause mortality, but low albumin and high fibrinogen levels were not in the Cox proportional hazards analysis. When only cardiovascular mortality was entered into the Cox model, high CRP and low Hb levels were the only significant predictors for mortality.

CONCLUSIONS

It can be concluded that, inflammation (elevated CRP) and anaemia (decreased Hb), were identified as significant independent non-traditional, disease-related cardiovascular risk factors that predict cardiovascular mortality in HD patients.

Authors+Show Affiliations

Department of Nephrology, Clinical Centre, University Sts. Cyril and Methodius Skopje, FYROM. sen@mt.net.mkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19582176

Citation

Selim, G, et al. "Inflammation and Anaemia as Predictors of Cardiovascular Mortality in Hemodialysis Patients." Hippokratia, vol. 11, no. 1, 2007, pp. 39-43.
Selim G, Stojceva-Taneva O, Ivanovski N, et al. Inflammation and anaemia as predictors of cardiovascular mortality in hemodialysis patients. Hippokratia. 2007;11(1):39-43.
Selim, G., Stojceva-Taneva, O., Ivanovski, N., Zafirovska, K., Sikole, A., Trajcevska, L., Asani, A., & Polenakovic, M. (2007). Inflammation and anaemia as predictors of cardiovascular mortality in hemodialysis patients. Hippokratia, 11(1), 39-43.
Selim G, et al. Inflammation and Anaemia as Predictors of Cardiovascular Mortality in Hemodialysis Patients. Hippokratia. 2007;11(1):39-43. PubMed PMID: 19582176.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inflammation and anaemia as predictors of cardiovascular mortality in hemodialysis patients. AU - Selim,G, AU - Stojceva-Taneva,O, AU - Ivanovski,N, AU - Zafirovska,K, AU - Sikole,A, AU - Trajcevska,L, AU - Asani,A, AU - Polenakovic,M, PY - 2009/7/8/entrez PY - 2007/1/1/pubmed PY - 2007/1/1/medline KW - CRP KW - cardiovascular mortality KW - hemodyalisis KW - non-traditional cardiovascular risk factor SP - 39 EP - 43 JF - Hippokratia JO - Hippokratia VL - 11 IS - 1 N2 - BACKGROUND: Cardiovascular diseases are the most common causes of death among hemodialysis (HD) patients, yet the risk factors for these events have not been well established. Our study objective was to determine predictors of cardiovascular mortality, considering the non-traditional/disease-related and treatment-related/ cardiovascular risk factor in HD patients. MATERIAL AND METHODS: Disease-related cardiovascular risk factors, such as anaemia, calcium-phosphate disorders, nutrition-inflammation and treatment/dialysis-related cardiovascular risk factors such as HD dose, using the index Kt/V were analyzed in 214 patients on HD. Mortality was monitored prospectively over a two year period. RESULTS: Fifty-three of the 214 HD patients died during the follow-up period and the main cause of death was cardiovascular events (56.6%), followed by infection/sepsis (26.4%). The patients who died were significantly older than those alive, had significantly lower serum levels of hemoglobin (Hb), albumin and Kt/V. Serum levels of calcium, C-reactive protein (CRP) and fibrinogen were significantly higher in patients who died during the follow-up period. Kaplan-Meier analysis showed that the all cause and cardiovascular mortality was considerably higher in patients with Hb<110 g/l, albumin <40 g/l, CRP>8 mg/l and spKt/V<1.2 (log rank, p=0.000/p=0.000, p=0.000/ p=0.001, p=0.000/p=0.000, p=0.000/p=0.000), respectively. No difference in cardiovascular mortality was observed between the fibrinogen <4 g/l> levels. High CRP, low Hb levels and low spKt/V were significant predictors of all-cause mortality, but low albumin and high fibrinogen levels were not in the Cox proportional hazards analysis. When only cardiovascular mortality was entered into the Cox model, high CRP and low Hb levels were the only significant predictors for mortality. CONCLUSIONS: It can be concluded that, inflammation (elevated CRP) and anaemia (decreased Hb), were identified as significant independent non-traditional, disease-related cardiovascular risk factors that predict cardiovascular mortality in HD patients. SN - 1790-8019 UR - https://www.unboundmedicine.com/medline/citation/19582176/Inflammation_and_anaemia_as_predictors_of_cardiovascular_mortality_in_hemodialysis_patients_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19582176/ DB - PRIME DP - Unbound Medicine ER -