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Trends in the molecular pathogenesis and clinical therapeutics of common neurodegenerative disorders.
Int J Mol Sci. 2009 Jun 03; 10(6):2510-57.IJ

Abstract

The term neurodegenerative disorders, encompasses a variety of underlying conditions, sporadic and/or familial and are characterized by the persistent loss of neuronal subtypes. These disorders can disrupt molecular pathways, synapses, neuronal subpopulations and local circuits in specific brain regions, as well as higher-order neural networks. Abnormal network activities may result in a vicious cycle, further impairing the integrity and functions of neurons and synapses, for example, through aberrant excitation or inhibition. The most common neurodegenerative disorders are Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis and Huntington's disease. The molecular features of these disorders have been extensively researched and various unique neurotherapeutic interventions have been developed. However, there is an enormous coercion to integrate the existing knowledge in order to intensify the reliability with which neurodegenerative disorders can be diagnosed and treated. The objective of this review article is therefore to assimilate these disorders' in terms of their neuropathology, neurogenetics, etiology, trends in pharmacological treatment, clinical management, and the use of innovative neurotherapeutic interventions.

Authors+Show Affiliations

University of the Witwatersrand, Department of Pharmacy and Pharmacology, Parktown, Johannesburg, South Africa.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19582217

Citation

Choonara, Yahya E., et al. "Trends in the Molecular Pathogenesis and Clinical Therapeutics of Common Neurodegenerative Disorders." International Journal of Molecular Sciences, vol. 10, no. 6, 2009, pp. 2510-57.
Choonara YE, Pillay V, du Toit LC, et al. Trends in the molecular pathogenesis and clinical therapeutics of common neurodegenerative disorders. Int J Mol Sci. 2009;10(6):2510-57.
Choonara, Y. E., Pillay, V., du Toit, L. C., Modi, G., Naidoo, D., Ndesendo, V. M., & Sibambo, S. R. (2009). Trends in the molecular pathogenesis and clinical therapeutics of common neurodegenerative disorders. International Journal of Molecular Sciences, 10(6), 2510-57. https://doi.org/10.3390/ijms10062510
Choonara YE, et al. Trends in the Molecular Pathogenesis and Clinical Therapeutics of Common Neurodegenerative Disorders. Int J Mol Sci. 2009 Jun 3;10(6):2510-57. PubMed PMID: 19582217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trends in the molecular pathogenesis and clinical therapeutics of common neurodegenerative disorders. AU - Choonara,Yahya E, AU - Pillay,Viness, AU - du Toit,Lisa C, AU - Modi,Girish, AU - Naidoo,Dinesh, AU - Ndesendo,Valence M, AU - Sibambo,Sibongile R, Y1 - 2009/06/03/ PY - 2009/04/22/received PY - 2009/04/28/revised PY - 2009/05/05/accepted PY - 2009/7/8/entrez PY - 2009/7/8/pubmed PY - 2009/7/8/medline KW - Alzheimer’s disease KW - Amyotrophic Lateral Sclerosis KW - Huntingtin KW - Huntington’s disease KW - Parkinson’s disease KW - Tau KW - amyloid-β protein KW - drug delivery KW - neuropathology KW - neurotherapeutics KW - α-Synuclein SP - 2510 EP - 57 JF - International journal of molecular sciences JO - Int J Mol Sci VL - 10 IS - 6 N2 - The term neurodegenerative disorders, encompasses a variety of underlying conditions, sporadic and/or familial and are characterized by the persistent loss of neuronal subtypes. These disorders can disrupt molecular pathways, synapses, neuronal subpopulations and local circuits in specific brain regions, as well as higher-order neural networks. Abnormal network activities may result in a vicious cycle, further impairing the integrity and functions of neurons and synapses, for example, through aberrant excitation or inhibition. The most common neurodegenerative disorders are Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis and Huntington's disease. The molecular features of these disorders have been extensively researched and various unique neurotherapeutic interventions have been developed. However, there is an enormous coercion to integrate the existing knowledge in order to intensify the reliability with which neurodegenerative disorders can be diagnosed and treated. The objective of this review article is therefore to assimilate these disorders' in terms of their neuropathology, neurogenetics, etiology, trends in pharmacological treatment, clinical management, and the use of innovative neurotherapeutic interventions. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/19582217/Trends_in_the_molecular_pathogenesis_and_clinical_therapeutics_of_common_neurodegenerative_disorders_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19582217/ DB - PRIME DP - Unbound Medicine ER -