Tags

Type your tag names separated by a space and hit enter

Level of education and the risk of lymphoma in the European prospective investigation into cancer and nutrition.
J Cancer Res Clin Oncol 2010; 136(1):71-7JC

Abstract

INTRODUCTION

Lymphomas belong to the few cancer sites with increasing incidence over past decades, and only a few risk factors have been established. We explored the association between education and the incidence of lymphoma in the prospective EPIC study.

MATERIALS AND METHODS

Within 3,567,410 person-years of follow-up, 1,319 lymphoma cases [1,253 non-Hodgkin lymphomas (NHL) and 66 Hodgkin lymphomas (HL)] were identified. Cox proportional hazard regression was used to examine the association between highest educational level (primary school or less, technical/professional school, secondary school, university) and lymphoma risk.

RESULTS

Overall, no consistent associations between educational level and lymphoma risk were observed; however, associations were found for sub-groups of the cohort. We observed a higher risk of B-NHL (HR = 1.31, 95% CI = 1.02–1.68; n = 583) in women with the highest education level (university) but not in men. Concerning sub-classes of B-NHL, a positive association between education and risk of B cell chronic lymphatic leukaemia (BCLL) was observed only in women. In both genders, the risk of diffuse large B cell lymphoma (DLBCL) was significantly lower for subjects with university degree (HR = 0.46, 95% CI = 0.27–0.79) versus lowest educational level. No association was found for HL.

CONCLUSION

We could not confirm an overall consistent association of education and risk of HL or NHL in this large prospective study; although, education was positively related to the incidence of BCLL and B-NHL (in women) but inversely to incidence of DLBCL. Due to limited number of cases in sub-classes and the large number of comparisons, the possibility of chance findings can not be excluded.

Authors+Show Affiliations

Division of Cancer Epidemiology (C020), German Cancer Research Center, Heidelberg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19582474

Citation

Hermann, Silke, et al. "Level of Education and the Risk of Lymphoma in the European Prospective Investigation Into Cancer and Nutrition." Journal of Cancer Research and Clinical Oncology, vol. 136, no. 1, 2010, pp. 71-7.
Hermann S, Rohrmann S, Linseisen J, et al. Level of education and the risk of lymphoma in the European prospective investigation into cancer and nutrition. J Cancer Res Clin Oncol. 2010;136(1):71-7.
Hermann, S., Rohrmann, S., Linseisen, J., Nieters, A., Khan, A., Gallo, V., ... Riboli, E. (2010). Level of education and the risk of lymphoma in the European prospective investigation into cancer and nutrition. Journal of Cancer Research and Clinical Oncology, 136(1), pp. 71-7. doi:10.1007/s00432-009-0638-9.
Hermann S, et al. Level of Education and the Risk of Lymphoma in the European Prospective Investigation Into Cancer and Nutrition. J Cancer Res Clin Oncol. 2010;136(1):71-7. PubMed PMID: 19582474.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Level of education and the risk of lymphoma in the European prospective investigation into cancer and nutrition. AU - Hermann,Silke, AU - Rohrmann,Sabine, AU - Linseisen,Jakob, AU - Nieters,Alexandra, AU - Khan,Aneire, AU - Gallo,Valentina, AU - Overvad,Kim, AU - Tjønneland,Anne, AU - Raaschou-Nielsen,Ole, AU - Bergmann,Manuela M, AU - Boeing,Heiner, AU - Becker,Nikolaus, AU - Kaaks,Rudolf, AU - Bueno-de-Mesquita,H Bas, AU - May,Anne M, AU - Vermeulen,Roel C H, AU - Bingham,Sheila, AU - Khaw,Kay-Tee, AU - Key,Timothy J, AU - Travis,Ruth C, AU - Trichopoulou,Antonia, AU - Georgila,Christina, AU - Triantafylou,Dimitra, AU - Celentano,Egidio, AU - Krogh,Vittorio, AU - Masala,Giovanna, AU - Tumino,Rosario, AU - Agudo,Antonio, AU - Altzibar,Jone M, AU - Ardanaz,Eva, AU - Martínez-García,Carmen, AU - Suárez,Marcial Vicente Argüelles, AU - Tormo,Maria José, AU - Braaten,Tonje, AU - Lund,Eiliv, AU - Manjer,Jonas, AU - Zackrisson,Sophia, AU - Hallmans,Göran, AU - Malmer,Beatrice, AU - Boffetta,Paolo, AU - Brennan,Paul, AU - Slimani,Nadia, AU - Vineis,Paolo, AU - Riboli,Elio, PY - 2009/03/20/received PY - 2009/06/19/accepted PY - 2009/7/8/entrez PY - 2009/7/8/pubmed PY - 2011/5/6/medline SP - 71 EP - 7 JF - Journal of cancer research and clinical oncology JO - J. Cancer Res. Clin. Oncol. VL - 136 IS - 1 N2 - INTRODUCTION: Lymphomas belong to the few cancer sites with increasing incidence over past decades, and only a few risk factors have been established. We explored the association between education and the incidence of lymphoma in the prospective EPIC study. MATERIALS AND METHODS: Within 3,567,410 person-years of follow-up, 1,319 lymphoma cases [1,253 non-Hodgkin lymphomas (NHL) and 66 Hodgkin lymphomas (HL)] were identified. Cox proportional hazard regression was used to examine the association between highest educational level (primary school or less, technical/professional school, secondary school, university) and lymphoma risk. RESULTS: Overall, no consistent associations between educational level and lymphoma risk were observed; however, associations were found for sub-groups of the cohort. We observed a higher risk of B-NHL (HR = 1.31, 95% CI = 1.02–1.68; n = 583) in women with the highest education level (university) but not in men. Concerning sub-classes of B-NHL, a positive association between education and risk of B cell chronic lymphatic leukaemia (BCLL) was observed only in women. In both genders, the risk of diffuse large B cell lymphoma (DLBCL) was significantly lower for subjects with university degree (HR = 0.46, 95% CI = 0.27–0.79) versus lowest educational level. No association was found for HL. CONCLUSION: We could not confirm an overall consistent association of education and risk of HL or NHL in this large prospective study; although, education was positively related to the incidence of BCLL and B-NHL (in women) but inversely to incidence of DLBCL. Due to limited number of cases in sub-classes and the large number of comparisons, the possibility of chance findings can not be excluded. SN - 1432-1335 UR - https://www.unboundmedicine.com/medline/citation/19582474/Level_of_education_and_the_risk_of_lymphoma_in_the_European_prospective_investigation_into_cancer_and_nutrition_ L2 - https://dx.doi.org/10.1007/s00432-009-0638-9 DB - PRIME DP - Unbound Medicine ER -