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Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects.
J Clin Endocrinol Metab. 2009 Oct; 94(10):4023-30.JC

Abstract

CONTEXT

Vitamin D receptors are present in many tissues. Hypovitaminosis D is considered to be a risk factor for atherosclerosis.

OBJECTIVE

This study explores the effects of vitamin D replacement on insulin sensitivity, endothelial function, inflammation, oxidative stress, and leptin in vitamin D-deficient subjects.

DESIGN, SETTING, AND PATIENTS

Twenty-three asymptomatic vitamin D-deficient subjects with 25-hydroxyvitamin D [25(OH)D] levels below 25 nmol/liter were compared with a control group that had a mean 25(OH)D level of 75 nmol/liter. The vitamin D-deficient group received 300,000 IU im monthly for 3 months. The following parameters were evaluated before and after treatment: vitamin D metabolites, leptin, endothelial function by brachial artery flow mediated dilatation (FMD), insulin sensitivity index based on oral glucose tolerance test, and lipid peroxidation as measures of thiobarbituric acid reactive substances (TBARS).

RESULTS

FMD measurements were significantly lower in 25(OH)D-deficient subjects than controls (P = 0.001) and improved after replacement therapy (P = 0.002). Posttreatment values of TBARS were significantly lower than pretreatment levels (P < 0.001). A positive correlation between FMD and 25(OH)D (r = 0.45; P = 0.001) and a negative correlation between FMD and TBARS (r = -0.28; P < 0.05) were observed. There was a significant increase in leptin levels after therapy, and the leptin levels were positively correlated with 25(OH)D levels (r = 0.45; P < 0.05).

CONCLUSIONS

This study shows that 25(OH)D deficiency is associated with endothelial dysfunction and increased lipid peroxidation. Replacement of vitamin D has favorable effects on endothelial function. Vitamin D deficiency can be seen as an independent risk factor of atherosclerosis. Hypovitaminosis D-associated endothelial dysfunction may predispose to higher rates of cardiovascular disease in the winter.

Authors+Show Affiliations

Section of Endocrinology and Metabolism, Marmara University School of Medicine, 34060 Istanbul, Turkey. ozlemtarcin@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

19584181

Citation

Tarcin, Ozlem, et al. "Effect of Vitamin D Deficiency and Replacement On Endothelial Function in Asymptomatic Subjects." The Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 10, 2009, pp. 4023-30.
Tarcin O, Yavuz DG, Ozben B, et al. Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects. J Clin Endocrinol Metab. 2009;94(10):4023-30.
Tarcin, O., Yavuz, D. G., Ozben, B., Telli, A., Ogunc, A. V., Yuksel, M., Toprak, A., Yazici, D., Sancak, S., Deyneli, O., & Akalin, S. (2009). Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects. The Journal of Clinical Endocrinology and Metabolism, 94(10), 4023-30. https://doi.org/10.1210/jc.2008-1212
Tarcin O, et al. Effect of Vitamin D Deficiency and Replacement On Endothelial Function in Asymptomatic Subjects. J Clin Endocrinol Metab. 2009;94(10):4023-30. PubMed PMID: 19584181.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects. AU - Tarcin,Ozlem, AU - Yavuz,Dilek Gogas, AU - Ozben,Beste, AU - Telli,Ahu, AU - Ogunc,Ayliz Velioglu, AU - Yuksel,Meral, AU - Toprak,Ahmet, AU - Yazici,Dilek, AU - Sancak,Seda, AU - Deyneli,Oguzhan, AU - Akalin,Sema, Y1 - 2009/07/07/ PY - 2009/7/9/entrez PY - 2009/7/9/pubmed PY - 2009/10/21/medline SP - 4023 EP - 30 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 94 IS - 10 N2 - CONTEXT: Vitamin D receptors are present in many tissues. Hypovitaminosis D is considered to be a risk factor for atherosclerosis. OBJECTIVE: This study explores the effects of vitamin D replacement on insulin sensitivity, endothelial function, inflammation, oxidative stress, and leptin in vitamin D-deficient subjects. DESIGN, SETTING, AND PATIENTS: Twenty-three asymptomatic vitamin D-deficient subjects with 25-hydroxyvitamin D [25(OH)D] levels below 25 nmol/liter were compared with a control group that had a mean 25(OH)D level of 75 nmol/liter. The vitamin D-deficient group received 300,000 IU im monthly for 3 months. The following parameters were evaluated before and after treatment: vitamin D metabolites, leptin, endothelial function by brachial artery flow mediated dilatation (FMD), insulin sensitivity index based on oral glucose tolerance test, and lipid peroxidation as measures of thiobarbituric acid reactive substances (TBARS). RESULTS: FMD measurements were significantly lower in 25(OH)D-deficient subjects than controls (P = 0.001) and improved after replacement therapy (P = 0.002). Posttreatment values of TBARS were significantly lower than pretreatment levels (P < 0.001). A positive correlation between FMD and 25(OH)D (r = 0.45; P = 0.001) and a negative correlation between FMD and TBARS (r = -0.28; P < 0.05) were observed. There was a significant increase in leptin levels after therapy, and the leptin levels were positively correlated with 25(OH)D levels (r = 0.45; P < 0.05). CONCLUSIONS: This study shows that 25(OH)D deficiency is associated with endothelial dysfunction and increased lipid peroxidation. Replacement of vitamin D has favorable effects on endothelial function. Vitamin D deficiency can be seen as an independent risk factor of atherosclerosis. Hypovitaminosis D-associated endothelial dysfunction may predispose to higher rates of cardiovascular disease in the winter. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/19584181/Effect_of_vitamin_D_deficiency_and_replacement_on_endothelial_function_in_asymptomatic_subjects_ DB - PRIME DP - Unbound Medicine ER -