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Effect of RG 12525, an oral leukotriene D4 antagonist, on the airway response to inhaled leukotriene D4 in subjects with mild asthma.
Br J Clin Pharmacol. 1991 Oct; 32(4):512-5.BJ

Abstract

We have studied the effect of RG 12525, an oral leukotriene D4 (LTD4) antagonist, on LTD4-induced bronchoconstriction in eight male subjects with mild asthma (baseline FEV1 greater than 80% predicted) in a double-blind, placebo-controlled fashion. RG 12525 800 mg displaced the dose-response curve for LTD4 to the right. The mean (95% confidence intervals) difference in log PC20FEV1 following RG 12525 and placebo was 2.88 (1.61, 4.17) doubling doses of LTD4 (P less than 0.01), a 7.5 fold difference. We conclude that RG 12525 when administered orally is an effective LTD4 antagonist in subjects with mild asthma.

Authors+Show Affiliations

Respiratory Medicine Unit, City Hospital, Nottingham.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1958449

Citation

Wahedna, I, et al. "Effect of RG 12525, an Oral Leukotriene D4 Antagonist, On the Airway Response to Inhaled Leukotriene D4 in Subjects With Mild Asthma." British Journal of Clinical Pharmacology, vol. 32, no. 4, 1991, pp. 512-5.
Wahedna I, Wisniewski AS, Tattersfield AE. Effect of RG 12525, an oral leukotriene D4 antagonist, on the airway response to inhaled leukotriene D4 in subjects with mild asthma. Br J Clin Pharmacol. 1991;32(4):512-5.
Wahedna, I., Wisniewski, A. S., & Tattersfield, A. E. (1991). Effect of RG 12525, an oral leukotriene D4 antagonist, on the airway response to inhaled leukotriene D4 in subjects with mild asthma. British Journal of Clinical Pharmacology, 32(4), 512-5.
Wahedna I, Wisniewski AS, Tattersfield AE. Effect of RG 12525, an Oral Leukotriene D4 Antagonist, On the Airway Response to Inhaled Leukotriene D4 in Subjects With Mild Asthma. Br J Clin Pharmacol. 1991;32(4):512-5. PubMed PMID: 1958449.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of RG 12525, an oral leukotriene D4 antagonist, on the airway response to inhaled leukotriene D4 in subjects with mild asthma. AU - Wahedna,I, AU - Wisniewski,A S, AU - Tattersfield,A E, PY - 1991/10/1/pubmed PY - 1991/10/1/medline PY - 1991/10/1/entrez SP - 512 EP - 5 JF - British journal of clinical pharmacology JO - Br J Clin Pharmacol VL - 32 IS - 4 N2 - We have studied the effect of RG 12525, an oral leukotriene D4 (LTD4) antagonist, on LTD4-induced bronchoconstriction in eight male subjects with mild asthma (baseline FEV1 greater than 80% predicted) in a double-blind, placebo-controlled fashion. RG 12525 800 mg displaced the dose-response curve for LTD4 to the right. The mean (95% confidence intervals) difference in log PC20FEV1 following RG 12525 and placebo was 2.88 (1.61, 4.17) doubling doses of LTD4 (P less than 0.01), a 7.5 fold difference. We conclude that RG 12525 when administered orally is an effective LTD4 antagonist in subjects with mild asthma. SN - 0306-5251 UR - https://www.unboundmedicine.com/medline/citation/1958449/Effect_of_RG_12525_an_oral_leukotriene_D4_antagonist_on_the_airway_response_to_inhaled_leukotriene_D4_in_subjects_with_mild_asthma_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0306-5251&date=1991&volume=32&issue=4&spage=512 DB - PRIME DP - Unbound Medicine ER -