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Blood lipid levels in relation to glucose status in seven populations of Asian origin without a prior history of diabetes: the DECODA study.
Diabetes Metab Res Rev. 2009 Sep; 25(6):549-57.DM

Abstract

BACKGROUND

Dyslipidaemia commonly coexists with diabetes. We investigated the association of lipid profiles with glucose levels in populations of Asian origin without a prior history of diabetes.

METHODS

Cross-sectional data of 10,374 men and 12,552 women aged 30-74 years from 14 cohorts, representing seven populations of Asian origin were jointly analysed. Multivariable adjusted linear regression analyses with standardized regression coefficients (beta) were performed to estimate relationships between lipids and plasma glucose.

RESULTS

Within each glucose category, fasting plasma glucose (FPG) levels were correlated with increasing levels of triglycerides (TGs), total cholesterol (TC), TC to high-density lipoprotein (HDL) ratio and non-HDL cholesterol (non-HDL-C) (p < 0.05 in most of the ethnic groups) and inversely associated with HDL-C (p < 0.05 in some, but not all, of the populations). The association of lipids with 2-h plasma glucose (2hPG) followed a similar pattern as that for the FPG, except that an inverse relationship between HDL-C and glucose was more commonly observed for 2hPG than for FPG among different ethnic groups.

CONCLUSIONS

Hyperglycaemia is associated with adverse lipid profiles in Asians without a prior history of diabetes. The 2hPG appears to be more closely associated with lipid profiles than does FPG. When assessing the risk of cardiovascular disease, the association of the dyslipidaemia with intermediate hyperglycaemia needs to be considered.

Authors+Show Affiliations

Department of Public Health, University of Helsinki, Helsinki, Finland. lei.zhang@ktl.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19585489

Citation

Zhang, L, et al. "Blood Lipid Levels in Relation to Glucose Status in Seven Populations of Asian Origin Without a Prior History of Diabetes: the DECODA Study." Diabetes/metabolism Research and Reviews, vol. 25, no. 6, 2009, pp. 549-57.
Zhang L, Qiao Q, Tuomilehto J, et al. Blood lipid levels in relation to glucose status in seven populations of Asian origin without a prior history of diabetes: the DECODA study. Diabetes Metab Res Rev. 2009;25(6):549-57.
Zhang, L., Qiao, Q., Tuomilehto, J., Hammar, N., Janus, E. D., Söderberg, S., Mohan, V., Ramachandran, A., Dong, Y. H., Lam, T. H., & Pang, Z. C. (2009). Blood lipid levels in relation to glucose status in seven populations of Asian origin without a prior history of diabetes: the DECODA study. Diabetes/metabolism Research and Reviews, 25(6), 549-57. https://doi.org/10.1002/dmrr.994
Zhang L, et al. Blood Lipid Levels in Relation to Glucose Status in Seven Populations of Asian Origin Without a Prior History of Diabetes: the DECODA Study. Diabetes Metab Res Rev. 2009;25(6):549-57. PubMed PMID: 19585489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blood lipid levels in relation to glucose status in seven populations of Asian origin without a prior history of diabetes: the DECODA study. AU - Zhang,L, AU - Qiao,Q, AU - Tuomilehto,J, AU - Hammar,N, AU - Janus,E D, AU - Söderberg,S, AU - Mohan,V, AU - Ramachandran,A, AU - Dong,Y H, AU - Lam,T H, AU - Pang,Z C, PY - 2009/7/9/entrez PY - 2009/7/9/pubmed PY - 2009/12/16/medline SP - 549 EP - 57 JF - Diabetes/metabolism research and reviews JO - Diabetes Metab. Res. Rev. VL - 25 IS - 6 N2 - BACKGROUND: Dyslipidaemia commonly coexists with diabetes. We investigated the association of lipid profiles with glucose levels in populations of Asian origin without a prior history of diabetes. METHODS: Cross-sectional data of 10,374 men and 12,552 women aged 30-74 years from 14 cohorts, representing seven populations of Asian origin were jointly analysed. Multivariable adjusted linear regression analyses with standardized regression coefficients (beta) were performed to estimate relationships between lipids and plasma glucose. RESULTS: Within each glucose category, fasting plasma glucose (FPG) levels were correlated with increasing levels of triglycerides (TGs), total cholesterol (TC), TC to high-density lipoprotein (HDL) ratio and non-HDL cholesterol (non-HDL-C) (p < 0.05 in most of the ethnic groups) and inversely associated with HDL-C (p < 0.05 in some, but not all, of the populations). The association of lipids with 2-h plasma glucose (2hPG) followed a similar pattern as that for the FPG, except that an inverse relationship between HDL-C and glucose was more commonly observed for 2hPG than for FPG among different ethnic groups. CONCLUSIONS: Hyperglycaemia is associated with adverse lipid profiles in Asians without a prior history of diabetes. The 2hPG appears to be more closely associated with lipid profiles than does FPG. When assessing the risk of cardiovascular disease, the association of the dyslipidaemia with intermediate hyperglycaemia needs to be considered. SN - 1520-7560 UR - https://www.unboundmedicine.com/medline/citation/19585489/Blood_lipid_levels_in_relation_to_glucose_status_in_seven_populations_of_Asian_origin_without_a_prior_history_of_diabetes:_the_DECODA_study_ L2 - https://doi.org/10.1002/dmrr.994 DB - PRIME DP - Unbound Medicine ER -