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Neurological mortality among U.S. veterans of the Persian Gulf War: 13-year follow-up.
Am J Ind Med 2009; 52(9):663-70AJ

Abstract

BACKGROUND

This study focuses on long-term mortality, specifically brain cancer, amyotrophic lateral sclerosis (ALS), Parkinson's disease, and multiple sclerosis (MS) of 621,902 veterans who served in the 1990-1991 Persian Gulf War (GW), and 746,248 non-GW veterans.

METHODS

Follow-up began with the date the veteran left the GW theater or May 1, 1991 and ended with the date of death or December 31, 2004. Cox proportional hazard models were used for analyses.

RESULTS

Adjusted mortality rate ratios (aRR) of GW veterans compared to non-GW veterans were not statistically significant for brain cancer (aRR = 0.90, 95% confidence interval (CI): 0.73, 1.11), MS (aRR = 0.61, 95% CI: 0.23, 1.63), Parkinson's disease (aRR = 0.71, 95% CI: 0.17, 2.99), or ALS (aRR = 0.96, 95% CI: 0.56, 1.62). GW veterans potentially exposed to nerve agents for 2 or more days and GW veterans exposed to oil well fire smoke were at increased risk for brain cancer mortality (aRR = 2.71, 95% CI: 1.25, 5.87; aRR = 1.81, 95% CI: 1.00, 3.27; respectively).

CONCLUSIONS

The risk of death due to ALS, MS, Parkinson's disease, and brain cancer was not associated with 1991 GW service in general. However, GW veterans potentially exposed to nerve agents at Khamisiyah, Iraq, and to oil well fire smoke had an increased risk of mortality due to brain cancer.

Authors+Show Affiliations

Department of Veterans Affairs, Environmental Epidemiology Service, Washington, District of Columbia 20420, USA. shannon.barth@va.govNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

19585544

Citation

Barth, Shannon K., et al. "Neurological Mortality Among U.S. Veterans of the Persian Gulf War: 13-year Follow-up." American Journal of Industrial Medicine, vol. 52, no. 9, 2009, pp. 663-70.
Barth SK, Kang HK, Bullman TA, et al. Neurological mortality among U.S. veterans of the Persian Gulf War: 13-year follow-up. Am J Ind Med. 2009;52(9):663-70.
Barth, S. K., Kang, H. K., Bullman, T. A., & Wallin, M. T. (2009). Neurological mortality among U.S. veterans of the Persian Gulf War: 13-year follow-up. American Journal of Industrial Medicine, 52(9), pp. 663-70. doi:10.1002/ajim.20718.
Barth SK, et al. Neurological Mortality Among U.S. Veterans of the Persian Gulf War: 13-year Follow-up. Am J Ind Med. 2009;52(9):663-70. PubMed PMID: 19585544.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurological mortality among U.S. veterans of the Persian Gulf War: 13-year follow-up. AU - Barth,Shannon K, AU - Kang,Han K, AU - Bullman,Tim A, AU - Wallin,Mitchell T, PY - 2009/7/9/entrez PY - 2009/7/9/pubmed PY - 2009/11/5/medline SP - 663 EP - 70 JF - American journal of industrial medicine JO - Am. J. Ind. Med. VL - 52 IS - 9 N2 - BACKGROUND: This study focuses on long-term mortality, specifically brain cancer, amyotrophic lateral sclerosis (ALS), Parkinson's disease, and multiple sclerosis (MS) of 621,902 veterans who served in the 1990-1991 Persian Gulf War (GW), and 746,248 non-GW veterans. METHODS: Follow-up began with the date the veteran left the GW theater or May 1, 1991 and ended with the date of death or December 31, 2004. Cox proportional hazard models were used for analyses. RESULTS: Adjusted mortality rate ratios (aRR) of GW veterans compared to non-GW veterans were not statistically significant for brain cancer (aRR = 0.90, 95% confidence interval (CI): 0.73, 1.11), MS (aRR = 0.61, 95% CI: 0.23, 1.63), Parkinson's disease (aRR = 0.71, 95% CI: 0.17, 2.99), or ALS (aRR = 0.96, 95% CI: 0.56, 1.62). GW veterans potentially exposed to nerve agents for 2 or more days and GW veterans exposed to oil well fire smoke were at increased risk for brain cancer mortality (aRR = 2.71, 95% CI: 1.25, 5.87; aRR = 1.81, 95% CI: 1.00, 3.27; respectively). CONCLUSIONS: The risk of death due to ALS, MS, Parkinson's disease, and brain cancer was not associated with 1991 GW service in general. However, GW veterans potentially exposed to nerve agents at Khamisiyah, Iraq, and to oil well fire smoke had an increased risk of mortality due to brain cancer. SN - 1097-0274 UR - https://www.unboundmedicine.com/medline/citation/19585544/Neurological_mortality_among_U_S__veterans_of_the_Persian_Gulf_War:_13_year_follow_up_ L2 - https://doi.org/10.1002/ajim.20718 DB - PRIME DP - Unbound Medicine ER -