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[Statistical analysis of the incidence of some cancers in the province of Taranto 1999-2001].
Epidemiol Prev. 2009 Jan-Apr; 33(1-2):37-44.EP

Abstract

OBJECTIVE

to estimate the spatial distribution of risk, in order to assess its correlation to environmental pollution exposure around the large production facilities located in the Taranto area, and to identify high risk areas not previously reported.

SETTING

Italy, Taranto province (581,508 inhabitants).

DESIGN

incidence data in 29 municipalities of the Taranto province were extracted from the Jonico Salentino Cancer Registry (RTJS) for the following cancer sites: lung (ICDX C33-C34); pleura, pleuric mesothelioma (ICDX C45.0); bladder, malignancies only (ICDX C67); brain (ICDX C70-72); non-Hodgkin lymphoma (ICDX C82-85, C96); leukaemia (ICDX C91-5). Age standardized incidence rates for the whole province were computed. High-level risk areas were classified using a Poisson model, computing area-specific p-values associated to the null hypothesis of no increased risk (i.e. relative risk equal to 1). A hierarchical spatial Bayesian model was estimated to strengthen results: specifically two additional variance components, accounting for relative risk spatial autocorrelation and excess heterogeneity respectively, were considered in the model specification. Bayesian mapping of disease incidence allows for the drawing of regularized (smoothed) maps. To adjust for the effect of socio-economic deprivation, a five-variable index was introduced into the model as an ecological covariate.

RESULTS

an increased risk of lung, pleura and bladder cancer was observed among male residents in the city of Taranto (respectively: SIR 1.24, p-value < 0.01; SIR: 2.21, p-value < 0.01; SIR 1.28, p-value < 0.01). For non-Hodgkin lymphoma, a significant value was observed in the city of Taranto for males (SIR 1.46, p-value < 0.01), as well as in the neighbouring area of Pulsano for females (SIR 3.88, p-value < 0.01). An unexpected increased risk of brain cancer was found in both sexe risk (especially among males) of lung, pleura and bladder cancer is likely related to the chemical pollutants and asbestos, due to the presence of many industries and shipyards in the city of Taranto.

Authors+Show Affiliations

Osservatorio epidemiologico regionale, Regione Puglia. graziano@dss.uniba.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ita

PubMed ID

19585874

Citation

Graziano, Giusi, et al. "[Statistical Analysis of the Incidence of some Cancers in the Province of Taranto 1999-2001]." Epidemiologia E Prevenzione, vol. 33, no. 1-2, 2009, pp. 37-44.
Graziano G, Bilancia M, Bisceglia L, et al. [Statistical analysis of the incidence of some cancers in the province of Taranto 1999-2001]. Epidemiol Prev. 2009;33(1-2):37-44.
Graziano, G., Bilancia, M., Bisceglia, L., de Nichilo, G., Pollice, A., & Assennato, G. (2009). [Statistical analysis of the incidence of some cancers in the province of Taranto 1999-2001]. Epidemiologia E Prevenzione, 33(1-2), 37-44.
Graziano G, et al. [Statistical Analysis of the Incidence of some Cancers in the Province of Taranto 1999-2001]. Epidemiol Prev. 2009 Jan-Apr;33(1-2):37-44. PubMed PMID: 19585874.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Statistical analysis of the incidence of some cancers in the province of Taranto 1999-2001]. AU - Graziano,Giusi, AU - Bilancia,Massimo, AU - Bisceglia,Lucia, AU - de Nichilo,Gigliola, AU - Pollice,Alessio, AU - Assennato,Giorgio, PY - 2009/7/10/entrez PY - 2009/7/10/pubmed PY - 2009/8/15/medline SP - 37 EP - 44 JF - Epidemiologia e prevenzione JO - Epidemiol Prev VL - 33 IS - 1-2 N2 - OBJECTIVE: to estimate the spatial distribution of risk, in order to assess its correlation to environmental pollution exposure around the large production facilities located in the Taranto area, and to identify high risk areas not previously reported. SETTING: Italy, Taranto province (581,508 inhabitants). DESIGN: incidence data in 29 municipalities of the Taranto province were extracted from the Jonico Salentino Cancer Registry (RTJS) for the following cancer sites: lung (ICDX C33-C34); pleura, pleuric mesothelioma (ICDX C45.0); bladder, malignancies only (ICDX C67); brain (ICDX C70-72); non-Hodgkin lymphoma (ICDX C82-85, C96); leukaemia (ICDX C91-5). Age standardized incidence rates for the whole province were computed. High-level risk areas were classified using a Poisson model, computing area-specific p-values associated to the null hypothesis of no increased risk (i.e. relative risk equal to 1). A hierarchical spatial Bayesian model was estimated to strengthen results: specifically two additional variance components, accounting for relative risk spatial autocorrelation and excess heterogeneity respectively, were considered in the model specification. Bayesian mapping of disease incidence allows for the drawing of regularized (smoothed) maps. To adjust for the effect of socio-economic deprivation, a five-variable index was introduced into the model as an ecological covariate. RESULTS: an increased risk of lung, pleura and bladder cancer was observed among male residents in the city of Taranto (respectively: SIR 1.24, p-value < 0.01; SIR: 2.21, p-value < 0.01; SIR 1.28, p-value < 0.01). For non-Hodgkin lymphoma, a significant value was observed in the city of Taranto for males (SIR 1.46, p-value < 0.01), as well as in the neighbouring area of Pulsano for females (SIR 3.88, p-value < 0.01). An unexpected increased risk of brain cancer was found in both sexe risk (especially among males) of lung, pleura and bladder cancer is likely related to the chemical pollutants and asbestos, due to the presence of many industries and shipyards in the city of Taranto. SN - 1120-9763 UR - https://www.unboundmedicine.com/medline/citation/19585874/[Statistical_analysis_of_the_incidence_of_some_cancers_in_the_province_of_Taranto_1999_2001]_ L2 - http://www.epidemiologiaeprevenzione.it/materiali/ARCHIVIO_PDF/2009/E&amp;P1-2/E&amp;P1-2_037_art3.pdf DB - PRIME DP - Unbound Medicine ER -