Tags

Type your tag names separated by a space and hit enter

Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention.

Abstract

More than 25 million people in the world today are affected by dementia, most suffering from Alzheimer's disease. In both developed and developing nations, Alzheimer's disease has had tremendous impact on the affected individuals, caregivers, and society. The etiological factors, other than older age and genetic susceptibility, remain to be determined. Nevertheless, increasing evidence strongly points to the potential risk roles of vascular risk factors and disorders (eg, cigarette smoking, midlife high blood pressure and obesity, diabetes, and cerebrovascular lesions) and the possible beneficial roles of psychosocial factors (eg, high education, active social engagement, physical exercise, and mentally stimulating activity) in the pathogenetic process and clinical manifestation of the dementing disorders. The long-term multidomain interventions toward the optimal control of multiple vascular risk factors and the maintenance of socially integrated lifestyles and mentally stimulating activities are expected to reduce the risk or postpone the clinical onset of dementia, including Alzheimer's disease.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • Authors+Show Affiliations

    ,

    Aging Research Center, Karolinska Institutet-Stockholm, Sweden. chengxuan.qiu@ki.se

    ,

    Source

    MeSH

    Aging
    Alzheimer Disease
    Cardiovascular Diseases
    Cognition
    Humans
    Incidence
    Models, Biological
    Prevalence
    Risk Factors
    Risk Reduction Behavior

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    19585947

    Citation

    Qiu, Chengxuan, et al. "Epidemiology of Alzheimer's Disease: Occurrence, Determinants, and Strategies Toward Intervention." Dialogues in Clinical Neuroscience, vol. 11, no. 2, 2009, pp. 111-28.
    Qiu C, Kivipelto M, von Strauss E. Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention. Dialogues Clin Neurosci. 2009;11(2):111-28.
    Qiu, C., Kivipelto, M., & von Strauss, E. (2009). Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention. Dialogues in Clinical Neuroscience, 11(2), pp. 111-28.
    Qiu C, Kivipelto M, von Strauss E. Epidemiology of Alzheimer's Disease: Occurrence, Determinants, and Strategies Toward Intervention. Dialogues Clin Neurosci. 2009;11(2):111-28. PubMed PMID: 19585947.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention. AU - Qiu,Chengxuan, AU - Kivipelto,Miia, AU - von Strauss,Eva, PY - 2009/7/10/entrez PY - 2009/7/10/pubmed PY - 2009/8/21/medline SP - 111 EP - 28 JF - Dialogues in clinical neuroscience JO - Dialogues Clin Neurosci VL - 11 IS - 2 N2 - More than 25 million people in the world today are affected by dementia, most suffering from Alzheimer's disease. In both developed and developing nations, Alzheimer's disease has had tremendous impact on the affected individuals, caregivers, and society. The etiological factors, other than older age and genetic susceptibility, remain to be determined. Nevertheless, increasing evidence strongly points to the potential risk roles of vascular risk factors and disorders (eg, cigarette smoking, midlife high blood pressure and obesity, diabetes, and cerebrovascular lesions) and the possible beneficial roles of psychosocial factors (eg, high education, active social engagement, physical exercise, and mentally stimulating activity) in the pathogenetic process and clinical manifestation of the dementing disorders. The long-term multidomain interventions toward the optimal control of multiple vascular risk factors and the maintenance of socially integrated lifestyles and mentally stimulating activities are expected to reduce the risk or postpone the clinical onset of dementia, including Alzheimer's disease. SN - 1294-8322 UR - https://www.unboundmedicine.com/medline/citation/19585947/Epidemiology_of_Alzheimer's_disease:_occurrence_determinants_and_strategies_toward_intervention_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19585947/ DB - PRIME DP - Unbound Medicine ER -