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Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention.
Dialogues Clin Neurosci 2009; 11(2):111-28DC

Abstract

More than 25 million people in the world today are affected by dementia, most suffering from Alzheimer's disease. In both developed and developing nations, Alzheimer's disease has had tremendous impact on the affected individuals, caregivers, and society. The etiological factors, other than older age and genetic susceptibility, remain to be determined. Nevertheless, increasing evidence strongly points to the potential risk roles of vascular risk factors and disorders (eg, cigarette smoking, midlife high blood pressure and obesity, diabetes, and cerebrovascular lesions) and the possible beneficial roles of psychosocial factors (eg, high education, active social engagement, physical exercise, and mentally stimulating activity) in the pathogenetic process and clinical manifestation of the dementing disorders. The long-term multidomain interventions toward the optimal control of multiple vascular risk factors and the maintenance of socially integrated lifestyles and mentally stimulating activities are expected to reduce the risk or postpone the clinical onset of dementia, including Alzheimer's disease.

Authors+Show Affiliations

Aging Research Center, Karolinska Institutet-Stockholm, Sweden. chengxuan.qiu@ki.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19585947

Citation

Qiu, Chengxuan, et al. "Epidemiology of Alzheimer's Disease: Occurrence, Determinants, and Strategies Toward Intervention." Dialogues in Clinical Neuroscience, vol. 11, no. 2, 2009, pp. 111-28.
Qiu C, Kivipelto M, von Strauss E. Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention. Dialogues Clin Neurosci. 2009;11(2):111-28.
Qiu, C., Kivipelto, M., & von Strauss, E. (2009). Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention. Dialogues in Clinical Neuroscience, 11(2), pp. 111-28.
Qiu C, Kivipelto M, von Strauss E. Epidemiology of Alzheimer's Disease: Occurrence, Determinants, and Strategies Toward Intervention. Dialogues Clin Neurosci. 2009;11(2):111-28. PubMed PMID: 19585947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention. AU - Qiu,Chengxuan, AU - Kivipelto,Miia, AU - von Strauss,Eva, PY - 2009/7/10/entrez PY - 2009/7/10/pubmed PY - 2009/8/21/medline SP - 111 EP - 28 JF - Dialogues in clinical neuroscience JO - Dialogues Clin Neurosci VL - 11 IS - 2 N2 - More than 25 million people in the world today are affected by dementia, most suffering from Alzheimer's disease. In both developed and developing nations, Alzheimer's disease has had tremendous impact on the affected individuals, caregivers, and society. The etiological factors, other than older age and genetic susceptibility, remain to be determined. Nevertheless, increasing evidence strongly points to the potential risk roles of vascular risk factors and disorders (eg, cigarette smoking, midlife high blood pressure and obesity, diabetes, and cerebrovascular lesions) and the possible beneficial roles of psychosocial factors (eg, high education, active social engagement, physical exercise, and mentally stimulating activity) in the pathogenetic process and clinical manifestation of the dementing disorders. The long-term multidomain interventions toward the optimal control of multiple vascular risk factors and the maintenance of socially integrated lifestyles and mentally stimulating activities are expected to reduce the risk or postpone the clinical onset of dementia, including Alzheimer's disease. SN - 1294-8322 UR - https://www.unboundmedicine.com/medline/citation/19585947/Epidemiology_of_Alzheimer's_disease:_occurrence_determinants_and_strategies_toward_intervention_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19585947/ DB - PRIME DP - Unbound Medicine ER -