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Prospective study of meat intake and dietary nitrates, nitrites, and nitrosamines and risk of adult glioma.
Am J Clin Nutr 2009; 90(3):570-7AJ

Abstract

BACKGROUND

The hypothesis that nitrosamine exposure may increase the risk of glioma has been circulating for several decades, but testing it has been difficult because of the ubiquitous nature of nitrosamine exposure. Diet has been the focus of many studies because it can substantially influence nitrosamine exposure, mostly from the endogenous formation of nitrosamines based on intake of nitrite and nitrate.

OBJECTIVE

The objective was to examine the relation between intakes of meats, nitrate, nitrite, and 2 nitrosamines [nitrosodimethylamine (NDMA) and nitrosopyrolidine (NPYR)] and glioma risk in a prospective analysis.

METHODS

Data from 3 US prospective cohort studies were combined for this analysis; 335 glioma cases were diagnosed during < or =24 y of follow-up. Dietary intake was assessed with food-frequency questionnaires. Nitrate, nitrite, and nitrosamine values were calculated based on published values of these nutrients in various foods over different periods in time. Cox proportional hazards models were used to estimate incidence rate ratios (RRs) and 95% CIs. Estimates from each cohort were pooled by using a random-effects model.

RESULTS

Risk of glioma was not elevated among individuals in the highest intake category of total processed meats (RR: 0.92; 95% CI: 0.48, 1.77), nitrate (RR: 1.02; 95% CI: 0.66, 1.58), nitrites (RR: 1.26; 95% CI: 0.89, 1.79), or NDMA (RR: 0.88; 95% CI: 0.57, 1.36) compared with the lowest category. No effect modification was observed by intake of vitamins C or E or other antioxidant measures.

CONCLUSION

We found no suggestion that intake of meat, nitrate, nitrite, or nitrosamines is related to the risk of glioma.

Authors+Show Affiliations

Department of Epidemiology and Public Health, Imperial College London, United Kingdom. d.michaud@imperial.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19587083

Citation

Michaud, Dominique S., et al. "Prospective Study of Meat Intake and Dietary Nitrates, Nitrites, and Nitrosamines and Risk of Adult Glioma." The American Journal of Clinical Nutrition, vol. 90, no. 3, 2009, pp. 570-7.
Michaud DS, Holick CN, Batchelor TT, et al. Prospective study of meat intake and dietary nitrates, nitrites, and nitrosamines and risk of adult glioma. Am J Clin Nutr. 2009;90(3):570-7.
Michaud, D. S., Holick, C. N., Batchelor, T. T., Giovannucci, E., & Hunter, D. J. (2009). Prospective study of meat intake and dietary nitrates, nitrites, and nitrosamines and risk of adult glioma. The American Journal of Clinical Nutrition, 90(3), pp. 570-7. doi:10.3945/ajcn.2008.27199.
Michaud DS, et al. Prospective Study of Meat Intake and Dietary Nitrates, Nitrites, and Nitrosamines and Risk of Adult Glioma. Am J Clin Nutr. 2009;90(3):570-7. PubMed PMID: 19587083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective study of meat intake and dietary nitrates, nitrites, and nitrosamines and risk of adult glioma. AU - Michaud,Dominique S, AU - Holick,Crystal N, AU - Batchelor,Tracy T, AU - Giovannucci,Edward, AU - Hunter,David J, Y1 - 2009/07/08/ PY - 2009/7/10/entrez PY - 2009/7/10/pubmed PY - 2009/9/30/medline SP - 570 EP - 7 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 90 IS - 3 N2 - BACKGROUND: The hypothesis that nitrosamine exposure may increase the risk of glioma has been circulating for several decades, but testing it has been difficult because of the ubiquitous nature of nitrosamine exposure. Diet has been the focus of many studies because it can substantially influence nitrosamine exposure, mostly from the endogenous formation of nitrosamines based on intake of nitrite and nitrate. OBJECTIVE: The objective was to examine the relation between intakes of meats, nitrate, nitrite, and 2 nitrosamines [nitrosodimethylamine (NDMA) and nitrosopyrolidine (NPYR)] and glioma risk in a prospective analysis. METHODS: Data from 3 US prospective cohort studies were combined for this analysis; 335 glioma cases were diagnosed during < or =24 y of follow-up. Dietary intake was assessed with food-frequency questionnaires. Nitrate, nitrite, and nitrosamine values were calculated based on published values of these nutrients in various foods over different periods in time. Cox proportional hazards models were used to estimate incidence rate ratios (RRs) and 95% CIs. Estimates from each cohort were pooled by using a random-effects model. RESULTS: Risk of glioma was not elevated among individuals in the highest intake category of total processed meats (RR: 0.92; 95% CI: 0.48, 1.77), nitrate (RR: 1.02; 95% CI: 0.66, 1.58), nitrites (RR: 1.26; 95% CI: 0.89, 1.79), or NDMA (RR: 0.88; 95% CI: 0.57, 1.36) compared with the lowest category. No effect modification was observed by intake of vitamins C or E or other antioxidant measures. CONCLUSION: We found no suggestion that intake of meat, nitrate, nitrite, or nitrosamines is related to the risk of glioma. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/19587083/Prospective_study_of_meat_intake_and_dietary_nitrates_nitrites_and_nitrosamines_and_risk_of_adult_glioma_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2008.27199 DB - PRIME DP - Unbound Medicine ER -