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Dietary patterns and breast cancer risk in women participating in the Black Women's Health Study.

Abstract

BACKGROUND

No studies have examined dietary patterns and breast cancer risk in a large cohort of African American women.

OBJECTIVE

We investigated the association between dietary patterns and breast cancer risk in the Black Women's Health Study.

DESIGN

This is a prospective cohort study of 50,778 participants followed biennially from 1995 through 2007. During 443,742 person-years of follow-up, 1094 incident cases of breast cancer were identified. Factor analysis was used to derive food patterns based on 69 food variables. We used Cox regression models to obtain incident rate ratios (IRRs) for breast cancer in relation to quintiles of each of the 2 dietary patterns, with adjustment for other breast cancer risk factors.

RESULTS

Through factor analysis, we identified 2 dietary patterns: Western (refined grains, processed meat, and sweets) and prudent (whole grains, vegetables, fruit, and fish). The prudent diet was weakly associated with lower breast cancer risk overall; P for trend = 0.06. In analyses stratified by body mass index (BMI; in kg/m(2)), the prudent dietary pattern was associated with a significantly lower risk of breast cancer in women with a BMI <25 (IRR: 0.64; 95% CI: 0.43, 0.93; P for trend = 0.01). The prudent dietary pattern was also associated with a significantly lower risk of breast cancer in premenopausal women (IRR: 0.70; 95% CI: 0.52, 0.96; P for trend = 0.01), and we found a significant inverse association for the prudent dietary pattern and estrogen receptor-negative breast cancer (IRR: 0.52; 95% CI: 0.28, 0.94; P for trend <0.01).

CONCLUSION

Our findings suggest that the prudent dietary pattern may protect against breast cancer in some black women.

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  • Authors+Show Affiliations

    ,

    National Cancer Institute, Bethesda, MD 20892-7335, USA. collinsta@mail.nih.gov

    , , ,

    Source

    MeSH

    Adult
    African Americans
    Body Mass Index
    Breast Neoplasms
    Cohort Studies
    Diet
    Diet Surveys
    Factor Analysis, Statistical
    Female
    Humans
    Incidence
    Middle Aged
    Premenopause
    Proportional Hazards Models
    Prospective Studies
    Receptors, Estrogen
    Risk Factors
    United States

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    19587089

    Citation

    Agurs-Collins, Tanya, et al. "Dietary Patterns and Breast Cancer Risk in Women Participating in the Black Women's Health Study." The American Journal of Clinical Nutrition, vol. 90, no. 3, 2009, pp. 621-8.
    Agurs-Collins T, Rosenberg L, Makambi K, et al. Dietary patterns and breast cancer risk in women participating in the Black Women's Health Study. Am J Clin Nutr. 2009;90(3):621-8.
    Agurs-Collins, T., Rosenberg, L., Makambi, K., Palmer, J. R., & Adams-Campbell, L. (2009). Dietary patterns and breast cancer risk in women participating in the Black Women's Health Study. The American Journal of Clinical Nutrition, 90(3), pp. 621-8. doi:10.3945/ajcn.2009.27666.
    Agurs-Collins T, et al. Dietary Patterns and Breast Cancer Risk in Women Participating in the Black Women's Health Study. Am J Clin Nutr. 2009;90(3):621-8. PubMed PMID: 19587089.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary patterns and breast cancer risk in women participating in the Black Women's Health Study. AU - Agurs-Collins,Tanya, AU - Rosenberg,Lynn, AU - Makambi,Kepher, AU - Palmer,Julie R, AU - Adams-Campbell,Lucile, Y1 - 2009/07/08/ PY - 2009/7/10/entrez PY - 2009/7/10/pubmed PY - 2009/9/30/medline SP - 621 EP - 8 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 90 IS - 3 N2 - BACKGROUND: No studies have examined dietary patterns and breast cancer risk in a large cohort of African American women. OBJECTIVE: We investigated the association between dietary patterns and breast cancer risk in the Black Women's Health Study. DESIGN: This is a prospective cohort study of 50,778 participants followed biennially from 1995 through 2007. During 443,742 person-years of follow-up, 1094 incident cases of breast cancer were identified. Factor analysis was used to derive food patterns based on 69 food variables. We used Cox regression models to obtain incident rate ratios (IRRs) for breast cancer in relation to quintiles of each of the 2 dietary patterns, with adjustment for other breast cancer risk factors. RESULTS: Through factor analysis, we identified 2 dietary patterns: Western (refined grains, processed meat, and sweets) and prudent (whole grains, vegetables, fruit, and fish). The prudent diet was weakly associated with lower breast cancer risk overall; P for trend = 0.06. In analyses stratified by body mass index (BMI; in kg/m(2)), the prudent dietary pattern was associated with a significantly lower risk of breast cancer in women with a BMI <25 (IRR: 0.64; 95% CI: 0.43, 0.93; P for trend = 0.01). The prudent dietary pattern was also associated with a significantly lower risk of breast cancer in premenopausal women (IRR: 0.70; 95% CI: 0.52, 0.96; P for trend = 0.01), and we found a significant inverse association for the prudent dietary pattern and estrogen receptor-negative breast cancer (IRR: 0.52; 95% CI: 0.28, 0.94; P for trend <0.01). CONCLUSION: Our findings suggest that the prudent dietary pattern may protect against breast cancer in some black women. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/19587089/Dietary_patterns_and_breast_cancer_risk_in_women_participating_in_the_Black_Women's_Health_Study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2009.27666 DB - PRIME DP - Unbound Medicine ER -