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Carbohydrate restriction, as a first-line dietary intervention, effectively reduces biomarkers of metabolic syndrome in Emirati adults.
J Nutr 2009; 139(9):1667-76JN

Abstract

The prevalence of diabetes mellitus (DM) in the United Arab Emirates is among the highest world-wide. Metabolic syndrome (MetS) predisposes individuals to DM; therefore, dietary interventions targeting MetS biomarkers are a high priority. We evaluated whether a carbohydrate-restricted diet (CRD) could effectively be used as a first-line therapy intervention in adult Emirati to improve the characteristics of MetS. A total of 39 participants (14 men, 25 women) 18-50 y, classified with MetS, followed a CRD (20-25% carbohydrate, 50-55% fat, 25-30% protein energy distribution). After 6 wk, 19 participants were randomly switched to the AHA diet (55% carbohydrate, 25-30% fat, 15-20% protein) whereas 20 participants continued with the CRD diet for an additional 6 wk. Fasting plasma lipids, 24-h dietary recalls, body composition, anthropometrics, blood pressure (BP), glucose, insulin, and plasma markers of inflammation were measured at baseline, wk 6, and wk 12. Dietary analysis indicated high compliance. At wk 6, the CRD (n = 39) resulted in decreased body weight (-13%), waist circumference (-4.5%), body fat (-10.6%), and plasma triglycerides (TG) (-38.7%) (P < 0.001). Significant decreases in LDL cholesterol, BP, glucose, insulin, and inflammatory markers and increases in adiponectin (P < 0.05) also occurred. After 12 wk, positive changes persisted for all participants, independent of diet. However, body weight and plasma TG and insulin were lower in the CRD (P < 0.05) group than in the CRD + AHA group. Results from this study suggest that a 6-wk CRD can effectively be used as a first-line diet therapy to rapidly improve features of MetS and cardiovascular risk in adult Emirati.

Authors+Show Affiliations

Department of Nutritional Sciences and 4Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19587123

Citation

Al-Sarraj, Taif, et al. "Carbohydrate Restriction, as a First-line Dietary Intervention, Effectively Reduces Biomarkers of Metabolic Syndrome in Emirati Adults." The Journal of Nutrition, vol. 139, no. 9, 2009, pp. 1667-76.
Al-Sarraj T, Saadi H, Calle MC, et al. Carbohydrate restriction, as a first-line dietary intervention, effectively reduces biomarkers of metabolic syndrome in Emirati adults. J Nutr. 2009;139(9):1667-76.
Al-Sarraj, T., Saadi, H., Calle, M. C., Volek, J. S., & Fernandez, M. L. (2009). Carbohydrate restriction, as a first-line dietary intervention, effectively reduces biomarkers of metabolic syndrome in Emirati adults. The Journal of Nutrition, 139(9), pp. 1667-76. doi:10.3945/jn.109.109603.
Al-Sarraj T, et al. Carbohydrate Restriction, as a First-line Dietary Intervention, Effectively Reduces Biomarkers of Metabolic Syndrome in Emirati Adults. J Nutr. 2009;139(9):1667-76. PubMed PMID: 19587123.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carbohydrate restriction, as a first-line dietary intervention, effectively reduces biomarkers of metabolic syndrome in Emirati adults. AU - Al-Sarraj,Taif, AU - Saadi,Hussein, AU - Calle,Mariana C, AU - Volek,Jeff S, AU - Fernandez,Maria Luz, Y1 - 2009/07/08/ PY - 2009/7/10/entrez PY - 2009/7/10/pubmed PY - 2009/9/18/medline SP - 1667 EP - 76 JF - The Journal of nutrition JO - J. Nutr. VL - 139 IS - 9 N2 - The prevalence of diabetes mellitus (DM) in the United Arab Emirates is among the highest world-wide. Metabolic syndrome (MetS) predisposes individuals to DM; therefore, dietary interventions targeting MetS biomarkers are a high priority. We evaluated whether a carbohydrate-restricted diet (CRD) could effectively be used as a first-line therapy intervention in adult Emirati to improve the characteristics of MetS. A total of 39 participants (14 men, 25 women) 18-50 y, classified with MetS, followed a CRD (20-25% carbohydrate, 50-55% fat, 25-30% protein energy distribution). After 6 wk, 19 participants were randomly switched to the AHA diet (55% carbohydrate, 25-30% fat, 15-20% protein) whereas 20 participants continued with the CRD diet for an additional 6 wk. Fasting plasma lipids, 24-h dietary recalls, body composition, anthropometrics, blood pressure (BP), glucose, insulin, and plasma markers of inflammation were measured at baseline, wk 6, and wk 12. Dietary analysis indicated high compliance. At wk 6, the CRD (n = 39) resulted in decreased body weight (-13%), waist circumference (-4.5%), body fat (-10.6%), and plasma triglycerides (TG) (-38.7%) (P < 0.001). Significant decreases in LDL cholesterol, BP, glucose, insulin, and inflammatory markers and increases in adiponectin (P < 0.05) also occurred. After 12 wk, positive changes persisted for all participants, independent of diet. However, body weight and plasma TG and insulin were lower in the CRD (P < 0.05) group than in the CRD + AHA group. Results from this study suggest that a 6-wk CRD can effectively be used as a first-line diet therapy to rapidly improve features of MetS and cardiovascular risk in adult Emirati. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/19587123/Carbohydrate_restriction_as_a_first_line_dietary_intervention_effectively_reduces_biomarkers_of_metabolic_syndrome_in_Emirati_adults_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.109.109603 DB - PRIME DP - Unbound Medicine ER -