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Responses of LDL and HDL particle size and distribution to omega-3 fatty acid supplementation and aerobic exercise.

Abstract

The purpose of this investigation was to determine the independent and combined effects of aerobic exercise and omega-3 fatty acid (n-3fa) supplementation on lipid and lipoproteins. Sedentary, normoglycemic, nonsmoking men (n = 11) were assigned to perform rest and exercise before and during n-3fa supplementation. Exercise consisted of 3 consecutive days of treadmill walking at 65% maximum O(2) consumption for 60 min. Supplementation consisted of 42 days of 4.55 g/day of n-3fa. A two-way factorial ANOVA with repeated measures revealed significant reductions in total cholesterol (P = 0.001, -9.2%) and triglyceride (P = 0.007, -32.4%) concentrations postexercise. In addition, exercise increased LDL peak particle size (P = 0.001) from 26.2 to 26.4 nm, but not HDL size. The n-3fa supplementation resulted in a significant shift in the distribution of HDL-cholesterol (HDL-C) carried by HDL(2b+2a) (P = 0.001, 14.2%) and HDL(3a+3b) (P = 0.001, -22.8%), despite no significant changes in lipid and lipoprotein-cholesterol concentrations. The majority of the shift in HDL-C was noted in HDL(2b) (P = 0.001, 20.9%) and HDL(3a) (P < 0.001, -31.0%) particles. There were no combined effects of exercise and n-3fa supplementation on lipids and lipoproteins. Three consecutive days of aerobic exercise reduced triglyceride and total cholesterol concentrations with a concomitant increase in LDL peak particle size. In contrast, n-3fa supplementation shifted HDL-C from HDL(3) particles to HDL(2) particles, despite no significant changes in HDL(2)-C and HDL(3)-C concentrations. Exercise and n-3fa supplementation do not synergistically improve serum lipids and lipoproteins, but rather independently affect the metabolism of lipids and lipoproteins.

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  • Authors+Show Affiliations

    ,

    Exercise Physiology Laboratory, Department of Kinesiology, Texas Woman's University, Denton, Texas, USA. wooten@bcm.edu

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    Source

    MeSH

    Adult
    Anaerobic Threshold
    Cholesterol, HDL
    Cholesterol, LDL
    Diet
    Dietary Supplements
    Energy Intake
    Exercise
    Fatty Acids, Omega-3
    Hemoglobins
    Humans
    Lipids
    Lipoproteins, HDL
    Lipoproteins, LDL
    Male
    Middle Aged
    Particle Size
    Rest
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19589957

    Citation

    Wooten, Joshua S., et al. "Responses of LDL and HDL Particle Size and Distribution to Omega-3 Fatty Acid Supplementation and Aerobic Exercise." Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 107, no. 3, 2009, pp. 794-800.
    Wooten JS, Biggerstaff KD, Ben-Ezra V. Responses of LDL and HDL particle size and distribution to omega-3 fatty acid supplementation and aerobic exercise. J Appl Physiol. 2009;107(3):794-800.
    Wooten, J. S., Biggerstaff, K. D., & Ben-Ezra, V. (2009). Responses of LDL and HDL particle size and distribution to omega-3 fatty acid supplementation and aerobic exercise. Journal of Applied Physiology (Bethesda, Md. : 1985), 107(3), pp. 794-800. doi:10.1152/japplphysiol.91062.2008.
    Wooten JS, Biggerstaff KD, Ben-Ezra V. Responses of LDL and HDL Particle Size and Distribution to Omega-3 Fatty Acid Supplementation and Aerobic Exercise. J Appl Physiol. 2009;107(3):794-800. PubMed PMID: 19589957.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Responses of LDL and HDL particle size and distribution to omega-3 fatty acid supplementation and aerobic exercise. AU - Wooten,Joshua S, AU - Biggerstaff,Kyle D, AU - Ben-Ezra,Vic, Y1 - 2009/07/09/ PY - 2009/7/11/entrez PY - 2009/7/11/pubmed PY - 2009/10/6/medline SP - 794 EP - 800 JF - Journal of applied physiology (Bethesda, Md. : 1985) JO - J. Appl. Physiol. VL - 107 IS - 3 N2 - The purpose of this investigation was to determine the independent and combined effects of aerobic exercise and omega-3 fatty acid (n-3fa) supplementation on lipid and lipoproteins. Sedentary, normoglycemic, nonsmoking men (n = 11) were assigned to perform rest and exercise before and during n-3fa supplementation. Exercise consisted of 3 consecutive days of treadmill walking at 65% maximum O(2) consumption for 60 min. Supplementation consisted of 42 days of 4.55 g/day of n-3fa. A two-way factorial ANOVA with repeated measures revealed significant reductions in total cholesterol (P = 0.001, -9.2%) and triglyceride (P = 0.007, -32.4%) concentrations postexercise. In addition, exercise increased LDL peak particle size (P = 0.001) from 26.2 to 26.4 nm, but not HDL size. The n-3fa supplementation resulted in a significant shift in the distribution of HDL-cholesterol (HDL-C) carried by HDL(2b+2a) (P = 0.001, 14.2%) and HDL(3a+3b) (P = 0.001, -22.8%), despite no significant changes in lipid and lipoprotein-cholesterol concentrations. The majority of the shift in HDL-C was noted in HDL(2b) (P = 0.001, 20.9%) and HDL(3a) (P < 0.001, -31.0%) particles. There were no combined effects of exercise and n-3fa supplementation on lipids and lipoproteins. Three consecutive days of aerobic exercise reduced triglyceride and total cholesterol concentrations with a concomitant increase in LDL peak particle size. In contrast, n-3fa supplementation shifted HDL-C from HDL(3) particles to HDL(2) particles, despite no significant changes in HDL(2)-C and HDL(3)-C concentrations. Exercise and n-3fa supplementation do not synergistically improve serum lipids and lipoproteins, but rather independently affect the metabolism of lipids and lipoproteins. SN - 8750-7587 UR - https://www.unboundmedicine.com/medline/citation/19589957/Responses_of_LDL_and_HDL_particle_size_and_distribution_to_omega_3_fatty_acid_supplementation_and_aerobic_exercise_ L2 - http://www.physiology.org/doi/full/10.1152/japplphysiol.91062.2008?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -