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Responses of LDL and HDL particle size and distribution to omega-3 fatty acid supplementation and aerobic exercise.
J Appl Physiol (1985) 2009; 107(3):794-800JA

Abstract

The purpose of this investigation was to determine the independent and combined effects of aerobic exercise and omega-3 fatty acid (n-3fa) supplementation on lipid and lipoproteins. Sedentary, normoglycemic, nonsmoking men (n = 11) were assigned to perform rest and exercise before and during n-3fa supplementation. Exercise consisted of 3 consecutive days of treadmill walking at 65% maximum O(2) consumption for 60 min. Supplementation consisted of 42 days of 4.55 g/day of n-3fa. A two-way factorial ANOVA with repeated measures revealed significant reductions in total cholesterol (P = 0.001, -9.2%) and triglyceride (P = 0.007, -32.4%) concentrations postexercise. In addition, exercise increased LDL peak particle size (P = 0.001) from 26.2 to 26.4 nm, but not HDL size. The n-3fa supplementation resulted in a significant shift in the distribution of HDL-cholesterol (HDL-C) carried by HDL(2b+2a) (P = 0.001, 14.2%) and HDL(3a+3b) (P = 0.001, -22.8%), despite no significant changes in lipid and lipoprotein-cholesterol concentrations. The majority of the shift in HDL-C was noted in HDL(2b) (P = 0.001, 20.9%) and HDL(3a) (P < 0.001, -31.0%) particles. There were no combined effects of exercise and n-3fa supplementation on lipids and lipoproteins. Three consecutive days of aerobic exercise reduced triglyceride and total cholesterol concentrations with a concomitant increase in LDL peak particle size. In contrast, n-3fa supplementation shifted HDL-C from HDL(3) particles to HDL(2) particles, despite no significant changes in HDL(2)-C and HDL(3)-C concentrations. Exercise and n-3fa supplementation do not synergistically improve serum lipids and lipoproteins, but rather independently affect the metabolism of lipids and lipoproteins.

Authors+Show Affiliations

Exercise Physiology Laboratory, Department of Kinesiology, Texas Woman's University, Denton, Texas, USA. wooten@bcm.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19589957

Citation

Wooten, Joshua S., et al. "Responses of LDL and HDL Particle Size and Distribution to Omega-3 Fatty Acid Supplementation and Aerobic Exercise." Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 107, no. 3, 2009, pp. 794-800.
Wooten JS, Biggerstaff KD, Ben-Ezra V. Responses of LDL and HDL particle size and distribution to omega-3 fatty acid supplementation and aerobic exercise. J Appl Physiol. 2009;107(3):794-800.
Wooten, J. S., Biggerstaff, K. D., & Ben-Ezra, V. (2009). Responses of LDL and HDL particle size and distribution to omega-3 fatty acid supplementation and aerobic exercise. Journal of Applied Physiology (Bethesda, Md. : 1985), 107(3), pp. 794-800. doi:10.1152/japplphysiol.91062.2008.
Wooten JS, Biggerstaff KD, Ben-Ezra V. Responses of LDL and HDL Particle Size and Distribution to Omega-3 Fatty Acid Supplementation and Aerobic Exercise. J Appl Physiol. 2009;107(3):794-800. PubMed PMID: 19589957.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Responses of LDL and HDL particle size and distribution to omega-3 fatty acid supplementation and aerobic exercise. AU - Wooten,Joshua S, AU - Biggerstaff,Kyle D, AU - Ben-Ezra,Vic, Y1 - 2009/07/09/ PY - 2009/7/11/entrez PY - 2009/7/11/pubmed PY - 2009/10/6/medline SP - 794 EP - 800 JF - Journal of applied physiology (Bethesda, Md. : 1985) JO - J. Appl. Physiol. VL - 107 IS - 3 N2 - The purpose of this investigation was to determine the independent and combined effects of aerobic exercise and omega-3 fatty acid (n-3fa) supplementation on lipid and lipoproteins. Sedentary, normoglycemic, nonsmoking men (n = 11) were assigned to perform rest and exercise before and during n-3fa supplementation. Exercise consisted of 3 consecutive days of treadmill walking at 65% maximum O(2) consumption for 60 min. Supplementation consisted of 42 days of 4.55 g/day of n-3fa. A two-way factorial ANOVA with repeated measures revealed significant reductions in total cholesterol (P = 0.001, -9.2%) and triglyceride (P = 0.007, -32.4%) concentrations postexercise. In addition, exercise increased LDL peak particle size (P = 0.001) from 26.2 to 26.4 nm, but not HDL size. The n-3fa supplementation resulted in a significant shift in the distribution of HDL-cholesterol (HDL-C) carried by HDL(2b+2a) (P = 0.001, 14.2%) and HDL(3a+3b) (P = 0.001, -22.8%), despite no significant changes in lipid and lipoprotein-cholesterol concentrations. The majority of the shift in HDL-C was noted in HDL(2b) (P = 0.001, 20.9%) and HDL(3a) (P < 0.001, -31.0%) particles. There were no combined effects of exercise and n-3fa supplementation on lipids and lipoproteins. Three consecutive days of aerobic exercise reduced triglyceride and total cholesterol concentrations with a concomitant increase in LDL peak particle size. In contrast, n-3fa supplementation shifted HDL-C from HDL(3) particles to HDL(2) particles, despite no significant changes in HDL(2)-C and HDL(3)-C concentrations. Exercise and n-3fa supplementation do not synergistically improve serum lipids and lipoproteins, but rather independently affect the metabolism of lipids and lipoproteins. SN - 8750-7587 UR - https://www.unboundmedicine.com/medline/citation/19589957/Responses_of_LDL_and_HDL_particle_size_and_distribution_to_omega_3_fatty_acid_supplementation_and_aerobic_exercise_ L2 - http://www.physiology.org/doi/full/10.1152/japplphysiol.91062.2008?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -