Tags

Type your tag names separated by a space and hit enter

Increased prevalence of anti-gliadin antibodies and anti-tissue transglutaminase antibodies in children with cerebral palsy.
J Pediatr Gastroenterol Nutr. 2009 Oct; 49(4):424-9.JP

Abstract

AIM AND OBJECTIVE

The aim of the study was to investigate whether there is any association between cerebral palsy (CP) and celiac disease (CD) in children.

PATIENTS AND METHODS

Ninety children between 18 months and 18 years of age (median 9 years) with CP were included. Antibodies (IgA and IgG) against gliadin (AGA), endomysium (EMA), and tissue transglutaminase (tTG) were measured. Children with elevated levels of these antibodies were offered a small-bowel biopsy.

RESULTS

Thirty-nine children showed an elevated level of 1 or more of the tested antibodies (43%). None had raised EMA antibodies. Presence of tetraplegia or dyskinesia was associated with increased antibody levels (P=0.045), as was a more severe functional type of CP (P=0.008). Children with elevated antibodies had a lower body weight (P=0.049), height (P=0.041), and body mass index (BMI) (P=0.014). Small-bowel biopsies were performed in 27 out of 39 children; 1 had CD and 2 had intraepithelial lymphocytosis.

CONCLUSIONS

A large number of children with CP had elevated AGA and/or anti-tTG. Because these elevations were associated with lower weight, height, and BMI, it seemed of interest to speculate on how these findings correlated to CP and CD. However, we found no correlation between CP and CD.

Authors+Show Affiliations

Department of Pediatrics, Orebro University Hospital, Orebro University, Orebro, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19590452

Citation

Stenberg, Reidun, et al. "Increased Prevalence of Anti-gliadin Antibodies and Anti-tissue Transglutaminase Antibodies in Children With Cerebral Palsy." Journal of Pediatric Gastroenterology and Nutrition, vol. 49, no. 4, 2009, pp. 424-9.
Stenberg R, Dahle C, Lindberg E, et al. Increased prevalence of anti-gliadin antibodies and anti-tissue transglutaminase antibodies in children with cerebral palsy. J Pediatr Gastroenterol Nutr. 2009;49(4):424-9.
Stenberg, R., Dahle, C., Lindberg, E., & Schollin, J. (2009). Increased prevalence of anti-gliadin antibodies and anti-tissue transglutaminase antibodies in children with cerebral palsy. Journal of Pediatric Gastroenterology and Nutrition, 49(4), 424-9. https://doi.org/10.1097/MPG.0b013e31819a4e52
Stenberg R, et al. Increased Prevalence of Anti-gliadin Antibodies and Anti-tissue Transglutaminase Antibodies in Children With Cerebral Palsy. J Pediatr Gastroenterol Nutr. 2009;49(4):424-9. PubMed PMID: 19590452.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased prevalence of anti-gliadin antibodies and anti-tissue transglutaminase antibodies in children with cerebral palsy. AU - Stenberg,Reidun, AU - Dahle,Charlotte, AU - Lindberg,Eva, AU - Schollin,Jens, PY - 2009/7/11/entrez PY - 2009/7/11/pubmed PY - 2010/5/15/medline SP - 424 EP - 9 JF - Journal of pediatric gastroenterology and nutrition JO - J Pediatr Gastroenterol Nutr VL - 49 IS - 4 N2 - AIM AND OBJECTIVE: The aim of the study was to investigate whether there is any association between cerebral palsy (CP) and celiac disease (CD) in children. PATIENTS AND METHODS: Ninety children between 18 months and 18 years of age (median 9 years) with CP were included. Antibodies (IgA and IgG) against gliadin (AGA), endomysium (EMA), and tissue transglutaminase (tTG) were measured. Children with elevated levels of these antibodies were offered a small-bowel biopsy. RESULTS: Thirty-nine children showed an elevated level of 1 or more of the tested antibodies (43%). None had raised EMA antibodies. Presence of tetraplegia or dyskinesia was associated with increased antibody levels (P=0.045), as was a more severe functional type of CP (P=0.008). Children with elevated antibodies had a lower body weight (P=0.049), height (P=0.041), and body mass index (BMI) (P=0.014). Small-bowel biopsies were performed in 27 out of 39 children; 1 had CD and 2 had intraepithelial lymphocytosis. CONCLUSIONS: A large number of children with CP had elevated AGA and/or anti-tTG. Because these elevations were associated with lower weight, height, and BMI, it seemed of interest to speculate on how these findings correlated to CP and CD. However, we found no correlation between CP and CD. SN - 1536-4801 UR - https://www.unboundmedicine.com/medline/citation/19590452/Increased_prevalence_of_anti_gliadin_antibodies_and_anti_tissue_transglutaminase_antibodies_in_children_with_cerebral_palsy_ L2 - https://doi.org/10.1097/MPG.0b013e31819a4e52 DB - PRIME DP - Unbound Medicine ER -