Tags

Type your tag names separated by a space and hit enter

Parental exposure to pesticides and childhood brain cancer: U.S. Atlantic coast childhood brain cancer study.
Environ Health Perspect. 2009 Jun; 117(6):1002-6.EH

Abstract

BACKGROUND

The etiology of childhood brain cancer remains largely unknown. However, previous studies have yielded suggestive associations with parental pesticide use.

OBJECTIVES

We aimed to evaluate parental exposure to pesticides at home and on the job in relation to the occurrence of brain cancer in children.

METHODS

We included 526 one-to-one-matched case-control pairs. Brain cancer cases were diagnosed at < 10 years of age, and were identified from statewide cancer registries of four U.S. Atlantic Coast states. We selected controls by random digit dialing. We conducted computer-assisted telephone interviews with mothers. Using information on residential pesticide use and jobs held by fathers during the 2-year period before the child's birth, we assessed potential exposure to insecticides, herbicides, and fungicides. For each job, two raters independently classified the probability and intensity of exposure; 421 pairs were available for final analysis. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using conditional logistic regression, after adjustment for maternal education.

RESULTS

A significant risk of astrocytoma was associated with exposures to herbicides from residential use (OR = 1.9; 95% CI, 1.2-3.0). Combining parental exposures to herbicides from both residential and occupational sources, the elevated risk remained significant (OR = 1.8; 95% CI, 1.1-3.1). We observed little association with primitive neuroectodermal tumors (PNET) for any of the pesticide classes or exposure sources considered.

CONCLUSIONS

Our observation is consistent with a previous literature reporting suggestive associations between parental exposure to pesticides and risk of astrocytoma in offspring but not PNET. However, these findings should be viewed in light of limitations in exposure assessment and effective sample size.

Authors+Show Affiliations

Division of Health Studies, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia 30341-3737, USA. Yshim@cdc.govNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

19590697

Citation

Shim, Youn K., et al. "Parental Exposure to Pesticides and Childhood Brain Cancer: U.S. Atlantic Coast Childhood Brain Cancer Study." Environmental Health Perspectives, vol. 117, no. 6, 2009, pp. 1002-6.
Shim YK, Mlynarek SP, van Wijngaarden E. Parental exposure to pesticides and childhood brain cancer: U.S. Atlantic coast childhood brain cancer study. Environ Health Perspect. 2009;117(6):1002-6.
Shim, Y. K., Mlynarek, S. P., & van Wijngaarden, E. (2009). Parental exposure to pesticides and childhood brain cancer: U.S. Atlantic coast childhood brain cancer study. Environmental Health Perspectives, 117(6), 1002-6. https://doi.org/10.1289/ehp.0800209
Shim YK, Mlynarek SP, van Wijngaarden E. Parental Exposure to Pesticides and Childhood Brain Cancer: U.S. Atlantic Coast Childhood Brain Cancer Study. Environ Health Perspect. 2009;117(6):1002-6. PubMed PMID: 19590697.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parental exposure to pesticides and childhood brain cancer: U.S. Atlantic coast childhood brain cancer study. AU - Shim,Youn K, AU - Mlynarek,Steven P, AU - van Wijngaarden,Edwin, Y1 - 2009/02/13/ PY - 2008/09/22/received PY - 2009/02/13/accepted PY - 2009/7/11/entrez PY - 2009/7/11/pubmed PY - 2009/9/24/medline KW - PNET KW - astrocytoma KW - brain cancer KW - children KW - parental exposure KW - pesticides SP - 1002 EP - 6 JF - Environmental health perspectives JO - Environ Health Perspect VL - 117 IS - 6 N2 - BACKGROUND: The etiology of childhood brain cancer remains largely unknown. However, previous studies have yielded suggestive associations with parental pesticide use. OBJECTIVES: We aimed to evaluate parental exposure to pesticides at home and on the job in relation to the occurrence of brain cancer in children. METHODS: We included 526 one-to-one-matched case-control pairs. Brain cancer cases were diagnosed at < 10 years of age, and were identified from statewide cancer registries of four U.S. Atlantic Coast states. We selected controls by random digit dialing. We conducted computer-assisted telephone interviews with mothers. Using information on residential pesticide use and jobs held by fathers during the 2-year period before the child's birth, we assessed potential exposure to insecticides, herbicides, and fungicides. For each job, two raters independently classified the probability and intensity of exposure; 421 pairs were available for final analysis. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using conditional logistic regression, after adjustment for maternal education. RESULTS: A significant risk of astrocytoma was associated with exposures to herbicides from residential use (OR = 1.9; 95% CI, 1.2-3.0). Combining parental exposures to herbicides from both residential and occupational sources, the elevated risk remained significant (OR = 1.8; 95% CI, 1.1-3.1). We observed little association with primitive neuroectodermal tumors (PNET) for any of the pesticide classes or exposure sources considered. CONCLUSIONS: Our observation is consistent with a previous literature reporting suggestive associations between parental exposure to pesticides and risk of astrocytoma in offspring but not PNET. However, these findings should be viewed in light of limitations in exposure assessment and effective sample size. SN - 1552-9924 UR - https://www.unboundmedicine.com/medline/citation/19590697/Parental_exposure_to_pesticides_and_childhood_brain_cancer:_U_S__Atlantic_coast_childhood_brain_cancer_study_ L2 - https://ehp.niehs.nih.gov/doi/10.1289/ehp.0800209?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -