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NAD(P)H: Quinone oxidoreductase 1, glutathione S-transferase M1, environmental tobacco smoke exposure, and childhood asthma.
Mutat Res. 2009 Aug; 678(1):53-8.MR

Abstract

Environmental tobacco smoke (ETS) exposure might increase the risk for childhood asthma, and we hypothesized the effect may be modified by the phase II genes NAD(P)H: quinone oxidoreductase 1 (NQO1) and glutathione S-transferase (GST) M1. To investigate the genetic and environmental associations with asthma, GSTM1 and NQO1 functional polymorphisms and ETS were analyzed in a two-staged cross-sectional study among elementary schoolchildren in Taiwan. Multiple logistic regression analysis revealed a significant association between the Ser allele of the NQO1 Pro187Ser polymorphism and asthma (OR=1.6, 95% CI 1.3-1.8). Although GSTM1 genotype itself was not significantly associated with asthma (OR=1.0, 95% CI 0.8-1.1), the GSTM1 genotype modified the association between the NQO1 polymorphism and asthma in children exposed to ETS (p=0.0002). The NQO1 gene might be involved in the development of asthma, especially in children carrying the GSTM1 null genotype who are exposed to ETS.

Authors+Show Affiliations

Institute of Environmental Health, China Medical University, 91 Hsieh-Shih Road, Taichung 404, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19591959

Citation

Li, Yu-Fen, et al. "NAD(P)H: Quinone Oxidoreductase 1, Glutathione S-transferase M1, Environmental Tobacco Smoke Exposure, and Childhood Asthma." Mutation Research, vol. 678, no. 1, 2009, pp. 53-8.
Li YF, Tseng PJ, Lin CC, et al. NAD(P)H: Quinone oxidoreductase 1, glutathione S-transferase M1, environmental tobacco smoke exposure, and childhood asthma. Mutat Res. 2009;678(1):53-8.
Li, Y. F., Tseng, P. J., Lin, C. C., Hung, C. L., Lin, S. C., Su, W. C., Huang, Y. L., Sung, F. C., & Tai, C. K. (2009). NAD(P)H: Quinone oxidoreductase 1, glutathione S-transferase M1, environmental tobacco smoke exposure, and childhood asthma. Mutation Research, 678(1), 53-8. https://doi.org/10.1016/j.mrgentox.2009.06.008
Li YF, et al. NAD(P)H: Quinone Oxidoreductase 1, Glutathione S-transferase M1, Environmental Tobacco Smoke Exposure, and Childhood Asthma. Mutat Res. 2009;678(1):53-8. PubMed PMID: 19591959.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - NAD(P)H: Quinone oxidoreductase 1, glutathione S-transferase M1, environmental tobacco smoke exposure, and childhood asthma. AU - Li,Yu-Fen, AU - Tseng,Pei-Jung, AU - Lin,Che-Chen, AU - Hung,Chiao-Ling, AU - Lin,Sheng-Che, AU - Su,Wan-Cing, AU - Huang,Yi-Ling, AU - Sung,Fung-Chang, AU - Tai,Chien-Kuo, Y1 - 2009/07/08/ PY - 2009/02/26/received PY - 2009/06/21/revised PY - 2009/06/30/accepted PY - 2009/7/14/entrez PY - 2009/7/14/pubmed PY - 2009/10/30/medline SP - 53 EP - 8 JF - Mutation research JO - Mutat Res VL - 678 IS - 1 N2 - Environmental tobacco smoke (ETS) exposure might increase the risk for childhood asthma, and we hypothesized the effect may be modified by the phase II genes NAD(P)H: quinone oxidoreductase 1 (NQO1) and glutathione S-transferase (GST) M1. To investigate the genetic and environmental associations with asthma, GSTM1 and NQO1 functional polymorphisms and ETS were analyzed in a two-staged cross-sectional study among elementary schoolchildren in Taiwan. Multiple logistic regression analysis revealed a significant association between the Ser allele of the NQO1 Pro187Ser polymorphism and asthma (OR=1.6, 95% CI 1.3-1.8). Although GSTM1 genotype itself was not significantly associated with asthma (OR=1.0, 95% CI 0.8-1.1), the GSTM1 genotype modified the association between the NQO1 polymorphism and asthma in children exposed to ETS (p=0.0002). The NQO1 gene might be involved in the development of asthma, especially in children carrying the GSTM1 null genotype who are exposed to ETS. SN - 0027-5107 UR - https://www.unboundmedicine.com/medline/citation/19591959/NAD_P_H:_Quinone_oxidoreductase_1_glutathione_S_transferase_M1_environmental_tobacco_smoke_exposure_and_childhood_asthma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1383-5718(09)00211-3 DB - PRIME DP - Unbound Medicine ER -