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Induction of 2',3'-cyclic nucleotide 3'-phosphodiesterase in demyelination of BALB/c mice caused by Angiostrongylus cantonensis.
J Comp Pathol. 2009 Nov; 141(4):248-53.JC

Abstract

Angiostrongylus cantonensis causes severe central nervous system (CNS) infection leading to chronic demyelinating disease. The biological role of 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNP) in myelin-related disease requires investigation. CNP expression was investigated in the brain of mice at six time points 5-25 days post-inoculation with A. cantonensis. CNP was measured in brain tissue by quantitative reverse transcription polymerase chain reaction and by western blotting in the cerebrospinal fluid (CSF). The concentration of CNP in the CSF was significantly up-regulated during the severe phase of meningoencephalitis or meningitis as compared with controls. Immunohistochemical labelling localized CNP expression to the cytoplasm of oligodendrocytes. These results suggest that CNP in the CSF from mice with angiostrongylosis is an indicator of myelin destruction. Therefore, measurement of CNP in the CSF of patients with eosinophilic meningitis may be useful in clinical management.

Authors+Show Affiliations

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19592007

Citation

Lin, K Y., and S C. Lai. "Induction of 2',3'-cyclic Nucleotide 3'-phosphodiesterase in Demyelination of BALB/c Mice Caused By Angiostrongylus Cantonensis." Journal of Comparative Pathology, vol. 141, no. 4, 2009, pp. 248-53.
Lin KY, Lai SC. Induction of 2',3'-cyclic nucleotide 3'-phosphodiesterase in demyelination of BALB/c mice caused by Angiostrongylus cantonensis. J Comp Pathol. 2009;141(4):248-53.
Lin, K. Y., & Lai, S. C. (2009). Induction of 2',3'-cyclic nucleotide 3'-phosphodiesterase in demyelination of BALB/c mice caused by Angiostrongylus cantonensis. Journal of Comparative Pathology, 141(4), 248-53. https://doi.org/10.1016/j.jcpa.2009.05.006
Lin KY, Lai SC. Induction of 2',3'-cyclic Nucleotide 3'-phosphodiesterase in Demyelination of BALB/c Mice Caused By Angiostrongylus Cantonensis. J Comp Pathol. 2009;141(4):248-53. PubMed PMID: 19592007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Induction of 2',3'-cyclic nucleotide 3'-phosphodiesterase in demyelination of BALB/c mice caused by Angiostrongylus cantonensis. AU - Lin,K Y, AU - Lai,S C, Y1 - 2009/07/09/ PY - 2009/03/19/received PY - 2009/05/01/revised PY - 2009/05/17/accepted PY - 2009/7/14/entrez PY - 2009/7/14/pubmed PY - 2010/1/27/medline SP - 248 EP - 53 JF - Journal of comparative pathology JO - J Comp Pathol VL - 141 IS - 4 N2 - Angiostrongylus cantonensis causes severe central nervous system (CNS) infection leading to chronic demyelinating disease. The biological role of 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNP) in myelin-related disease requires investigation. CNP expression was investigated in the brain of mice at six time points 5-25 days post-inoculation with A. cantonensis. CNP was measured in brain tissue by quantitative reverse transcription polymerase chain reaction and by western blotting in the cerebrospinal fluid (CSF). The concentration of CNP in the CSF was significantly up-regulated during the severe phase of meningoencephalitis or meningitis as compared with controls. Immunohistochemical labelling localized CNP expression to the cytoplasm of oligodendrocytes. These results suggest that CNP in the CSF from mice with angiostrongylosis is an indicator of myelin destruction. Therefore, measurement of CNP in the CSF of patients with eosinophilic meningitis may be useful in clinical management. SN - 1532-3129 UR - https://www.unboundmedicine.com/medline/citation/19592007/Induction_of_2'3'_cyclic_nucleotide_3'_phosphodiesterase_in_demyelination_of_BALB/c_mice_caused_by_Angiostrongylus_cantonensis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9975(09)00076-0 DB - PRIME DP - Unbound Medicine ER -