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Assessment of artifacts and reproducibility across spectral- and time-domain optical coherence tomography devices.
Ophthalmology. 2009 Oct; 116(10):1960-70.O

Abstract

PURPOSE

To report the frequency of optical coherence tomography (OCT) scan artifacts and to compare macular thickness measurements, interscan reproducibility, and interdevice agreeability across 3 spectral-domain (SD) OCT (also known as Fourier domain; Cirrus HD-OCT, RTVue-100, and Topcon 3D-OCT 1000) devices and 1 time-domain (TD) OCT (Stratus OCT) device.

DESIGN

Prospective, noncomparative, noninterventional case series.

PARTICIPANTS

Fifty-two patients seen at the New England Eye Center, Tufts Medical Center Retina Service, between February and August 2008.

METHODS

Two scans were performed for each of the SD OCT protocols: Cirrus macular cube 512 x 128 (software version 3.0; Carl Zeiss Meditec, Inc., Dublin, CA), RTVue (E)MM5 and MM6 (software version 3.5; Optovue, Inc., Fremont, CA), Topcon 3D Macular and Radial (software version 2.12; Topcon, Inc., Paramus, NJ), in addition to 1 TD OCT scan via Stratus macular thickness protocol (software version 4.0; Carl Zeiss Meditec, Inc.). Scans were inspected for 6 types of OCT scan artifacts and were analyzed. Interscan reproducibility and interdevice agreeability were assessed by intraclass correlation coefficients (ICCs) and Bland-Altman plots, respectively.

MAIN OUTCOME MEASURES

Optical coherence tomography image artifacts, macular thickness, reproducibility, and agreeability.

RESULTS

Time-domain OCT scans contained a significantly higher percentage of clinically significant improper central foveal thickness (IFT) after manual correction (11-mum change or more) compared with SD OCT scans. Cirrus HD-OCT had a significantly lower percentage of clinically significant IFT (11.1%) compared with the other SD OCT devices (Topcon 3D, 20.4%; Topcon Radial, 29.6%; RTVue (E)MM5, 42.6%; RTVue MM6, 24.1%; P = 0.001). All 3 SD OCT devices had central foveal subfield thicknesses that were significantly more than that of TD OCT after manual correction (P<0.0001). All 3 SD OCT devices demonstrated a high degree of reproducibility in the central foveal region (ICCs, 0.92-0.97). Bland-Altman plots showed low agreeability between TD and SD OCT scans.

CONCLUSIONS

Out of all OCT devices analyzed, cirrus HD-OCT scans exhibited the lowest occurrence of any artifacts (68.5%), IFT (40.7%), and clinically significant IFT (11.1%), whereas Stratus OCT scans exhibited the highest occurrence of clinically significant IFT. Further work on improving segmentation algorithm to decrease artifacts is warranted.

Authors+Show Affiliations

New England Eye Center, Tufts Medical Center, Boston, MA 02111, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

19592109

Citation

Ho, Joseph, et al. "Assessment of Artifacts and Reproducibility Across Spectral- and Time-domain Optical Coherence Tomography Devices." Ophthalmology, vol. 116, no. 10, 2009, pp. 1960-70.
Ho J, Sull AC, Vuong LN, et al. Assessment of artifacts and reproducibility across spectral- and time-domain optical coherence tomography devices. Ophthalmology. 2009;116(10):1960-70.
Ho, J., Sull, A. C., Vuong, L. N., Chen, Y., Liu, J., Fujimoto, J. G., Schuman, J. S., & Duker, J. S. (2009). Assessment of artifacts and reproducibility across spectral- and time-domain optical coherence tomography devices. Ophthalmology, 116(10), 1960-70. https://doi.org/10.1016/j.ophtha.2009.03.034
Ho J, et al. Assessment of Artifacts and Reproducibility Across Spectral- and Time-domain Optical Coherence Tomography Devices. Ophthalmology. 2009;116(10):1960-70. PubMed PMID: 19592109.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of artifacts and reproducibility across spectral- and time-domain optical coherence tomography devices. AU - Ho,Joseph, AU - Sull,Alan C, AU - Vuong,Laurel N, AU - Chen,Yueli, AU - Liu,Jonathan, AU - Fujimoto,James G, AU - Schuman,Joel S, AU - Duker,Jay S, Y1 - 2009/07/09/ PY - 2008/12/16/received PY - 2009/03/18/revised PY - 2009/03/19/accepted PY - 2009/7/14/entrez PY - 2009/7/14/pubmed PY - 2009/10/17/medline SP - 1960 EP - 70 JF - Ophthalmology JO - Ophthalmology VL - 116 IS - 10 N2 - PURPOSE: To report the frequency of optical coherence tomography (OCT) scan artifacts and to compare macular thickness measurements, interscan reproducibility, and interdevice agreeability across 3 spectral-domain (SD) OCT (also known as Fourier domain; Cirrus HD-OCT, RTVue-100, and Topcon 3D-OCT 1000) devices and 1 time-domain (TD) OCT (Stratus OCT) device. DESIGN: Prospective, noncomparative, noninterventional case series. PARTICIPANTS: Fifty-two patients seen at the New England Eye Center, Tufts Medical Center Retina Service, between February and August 2008. METHODS: Two scans were performed for each of the SD OCT protocols: Cirrus macular cube 512 x 128 (software version 3.0; Carl Zeiss Meditec, Inc., Dublin, CA), RTVue (E)MM5 and MM6 (software version 3.5; Optovue, Inc., Fremont, CA), Topcon 3D Macular and Radial (software version 2.12; Topcon, Inc., Paramus, NJ), in addition to 1 TD OCT scan via Stratus macular thickness protocol (software version 4.0; Carl Zeiss Meditec, Inc.). Scans were inspected for 6 types of OCT scan artifacts and were analyzed. Interscan reproducibility and interdevice agreeability were assessed by intraclass correlation coefficients (ICCs) and Bland-Altman plots, respectively. MAIN OUTCOME MEASURES: Optical coherence tomography image artifacts, macular thickness, reproducibility, and agreeability. RESULTS: Time-domain OCT scans contained a significantly higher percentage of clinically significant improper central foveal thickness (IFT) after manual correction (11-mum change or more) compared with SD OCT scans. Cirrus HD-OCT had a significantly lower percentage of clinically significant IFT (11.1%) compared with the other SD OCT devices (Topcon 3D, 20.4%; Topcon Radial, 29.6%; RTVue (E)MM5, 42.6%; RTVue MM6, 24.1%; P = 0.001). All 3 SD OCT devices had central foveal subfield thicknesses that were significantly more than that of TD OCT after manual correction (P<0.0001). All 3 SD OCT devices demonstrated a high degree of reproducibility in the central foveal region (ICCs, 0.92-0.97). Bland-Altman plots showed low agreeability between TD and SD OCT scans. CONCLUSIONS: Out of all OCT devices analyzed, cirrus HD-OCT scans exhibited the lowest occurrence of any artifacts (68.5%), IFT (40.7%), and clinically significant IFT (11.1%), whereas Stratus OCT scans exhibited the highest occurrence of clinically significant IFT. Further work on improving segmentation algorithm to decrease artifacts is warranted. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/19592109/Assessment_of_artifacts_and_reproducibility_across_spectral__and_time_domain_optical_coherence_tomography_devices_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(09)00298-X DB - PRIME DP - Unbound Medicine ER -