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Efficacy and safety of very-low-calorie diet in Taiwanese: a multicenter randomized, controlled trial.
Nutrition. 2009 Nov-Dec; 25(11-12):1129-36.N

Abstract

OBJECTIVE

Very-low-calorie diets (VLCDs) are an effective method for weight reduction in Caucasians. This study investigated the efficacy and safety of two different VLCDs (450 or 800kcal/d) in obese Taiwanese.

METHODS

132 participants with BMI > or =30kg/m(2) were randomized to two VLCD groups for body weight reduction for 12 weeks. Each group had 66 participants. Anthropometric and metabolic parameters were measured.

RESULTS

The intention-to-treat analysis revealed that the percentage change in body weight over the 12-week treatment period was -9.14% in the VLCD-450 group and -8.98% in the VLCD-800 group. A total of 27 (40.9%) participants in the VLCD-450 group and 29 (43.9%) participants in the VLCD-800 group achieved 10% or more weight loss at the end of treatment. The body weight, waist circumference, hip circumference, fat mass, blood pressure, triglycerides, and blood glucose were statistically improved from baseline but not between the two groups. The improvement rate of nonalcoholic fatty liver disease (NAFLD) was 41.5% in the VLCD-450 group and 50.0% in the VLCD-800 group. The incidence of adverse events did not differ significantly between the groups and no serious adverse events were reported in either group.

CONCLUSION

Both the VLCD-450 and 800kcal/d can effectively and safely reduce body weight and improve NAFLD in 12 weeks in obese Taiwanese participants. However, there is no additional benefit in prescribing the more restrictive diet intervention in Taiwanese.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Lin WY
Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan.
Wu CH
No affiliation info available
Chu NF
No affiliation info available
Chang CJ
No affiliation info available

MeSH

AdultBlood GlucoseBlood PressureBody SizeBody WeightDiet, ReducingEnergy IntakeFatty LiverFemaleHumansIntention to Treat AnalysisMaleObesityTaiwanTriglyceridesYoung Adult

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19592223

Clinical Trial Links

Effect of VLCD on the Reduction of Liver Steatosis and Fibrosis in Subjects With Obesity and NAFLD

Citation

Lin, Wen-Yuan, et al. "Efficacy and Safety of Very-low-calorie Diet in Taiwanese: a Multicenter Randomized, Controlled Trial." Nutrition (Burbank, Los Angeles County, Calif.), vol. 25, no. 11-12, 2009, pp. 1129-36.
Lin WY, Wu CH, Chu NF, et al. Efficacy and safety of very-low-calorie diet in Taiwanese: a multicenter randomized, controlled trial. Nutrition. 2009;25(11-12):1129-36.
Lin, W. Y., Wu, C. H., Chu, N. F., & Chang, C. J. (2009). Efficacy and safety of very-low-calorie diet in Taiwanese: a multicenter randomized, controlled trial. Nutrition (Burbank, Los Angeles County, Calif.), 25(11-12), 1129-36. https://doi.org/10.1016/j.nut.2009.02.008
Lin WY, et al. Efficacy and Safety of Very-low-calorie Diet in Taiwanese: a Multicenter Randomized, Controlled Trial. Nutrition. 2009 Nov-Dec;25(11-12):1129-36. PubMed PMID: 19592223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy and safety of very-low-calorie diet in Taiwanese: a multicenter randomized, controlled trial. AU - Lin,Wen-Yuan, AU - Wu,Chih-Hsing, AU - Chu,Nain-Feng, AU - Chang,Chih-Jen, Y1 - 2009/07/09/ PY - 2008/10/25/received PY - 2009/02/25/revised PY - 2009/02/26/accepted PY - 2009/7/14/entrez PY - 2009/7/14/pubmed PY - 2010/2/17/medline SP - 1129 EP - 36 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 25 IS - 11-12 N2 - OBJECTIVE: Very-low-calorie diets (VLCDs) are an effective method for weight reduction in Caucasians. This study investigated the efficacy and safety of two different VLCDs (450 or 800kcal/d) in obese Taiwanese. METHODS: 132 participants with BMI > or =30kg/m(2) were randomized to two VLCD groups for body weight reduction for 12 weeks. Each group had 66 participants. Anthropometric and metabolic parameters were measured. RESULTS: The intention-to-treat analysis revealed that the percentage change in body weight over the 12-week treatment period was -9.14% in the VLCD-450 group and -8.98% in the VLCD-800 group. A total of 27 (40.9%) participants in the VLCD-450 group and 29 (43.9%) participants in the VLCD-800 group achieved 10% or more weight loss at the end of treatment. The body weight, waist circumference, hip circumference, fat mass, blood pressure, triglycerides, and blood glucose were statistically improved from baseline but not between the two groups. The improvement rate of nonalcoholic fatty liver disease (NAFLD) was 41.5% in the VLCD-450 group and 50.0% in the VLCD-800 group. The incidence of adverse events did not differ significantly between the groups and no serious adverse events were reported in either group. CONCLUSION: Both the VLCD-450 and 800kcal/d can effectively and safely reduce body weight and improve NAFLD in 12 weeks in obese Taiwanese participants. However, there is no additional benefit in prescribing the more restrictive diet intervention in Taiwanese. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/19592223/Efficacy_and_safety_of_very_low_calorie_diet_in_Taiwanese:_a_multicenter_randomized_controlled_trial_ DB - PRIME DP - Unbound Medicine ER -