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Heart rate variability increases with reductions in cigarette smoke exposure after 3 days.
J Cardiovasc Pharmacol Ther. 2009 Sep; 14(3):192-8.JC

Abstract

BACKGROUND

Smoking has been shown to influence the tone of the autonomic nervous system as reflected by heart rate variability (HRV). To date, no information is available as to whether 24-hour HRV might differentiate users of different tobacco products.

OBJECTIVE

To assess the differences in HRV derived from the 24-hour electrocardiogram (ECG) following the use of 2 tobacco products of potentially different exposures.

METHODS

Thirty adult Caucasian male smokers (mean age: 42.8 + 5.7 years) smoking 20 to 40 cigarettes/ day were randomized in a 3-way crossover study design to either smoke a conventional cigarette (CC, tar: 11 mg, Nic: 0.8 mg), to use the Electrically Heated Cigarette Smoking System (EHCSS: tar: 5 mg, Nic: 0.3 mg, according to the Federal Trade Commission [FTC]), or to stop smoking (NS) for 3 days each. The 24 hours ECGs were recorded during the last 24 hours of each exposure period.

RESULTS

A 24-hour ECG showed highest mean values for standard deviation of all normal-to-normal heart beat (NN) intervals (SDNN), standard deviation of all 5-minute averaged NN intervals in a 24-hour period (SDANN), mean of the standard deviations of the NN intervals calculated from all 5-minute segments in a 24-hour period (SDNNI), percentage (P) of all NN intervals that differ by 50 milliseconds of all NN (PNN50%), the square root of the mean of all squared differences between adjacent NN intervals in 24-hour period (RMSSD), and total number of all NN intervals divided by the height of the histogram of all NN intervals measured on a discrete scale with bins of 7 x 8125 ms (1/128 seconds; HRVTI) when participants stopped smoking followed by the use of the reduced exposure product and CC.

CONCLUSION

Heart rate variability tended to increase with reduced smoke exposure.

Authors+Show Affiliations

Philip Morris USA, Richmond, Virginia, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19592602

Citation

Munjal, Sagar, et al. "Heart Rate Variability Increases With Reductions in Cigarette Smoke Exposure After 3 Days." Journal of Cardiovascular Pharmacology and Therapeutics, vol. 14, no. 3, 2009, pp. 192-8.
Munjal S, Koval T, Muhammad R, et al. Heart rate variability increases with reductions in cigarette smoke exposure after 3 days. J Cardiovasc Pharmacol Ther. 2009;14(3):192-8.
Munjal, S., Koval, T., Muhammad, R., Jin, Y., Demmel, V., Roethig, H. J., Mendes, P., & Unverdorben, M. (2009). Heart rate variability increases with reductions in cigarette smoke exposure after 3 days. Journal of Cardiovascular Pharmacology and Therapeutics, 14(3), 192-8. https://doi.org/10.1177/1074248409340340
Munjal S, et al. Heart Rate Variability Increases With Reductions in Cigarette Smoke Exposure After 3 Days. J Cardiovasc Pharmacol Ther. 2009;14(3):192-8. PubMed PMID: 19592602.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heart rate variability increases with reductions in cigarette smoke exposure after 3 days. AU - Munjal,Sagar, AU - Koval,Tamara, AU - Muhammad,Raheema, AU - Jin,Yan, AU - Demmel,Valentin, AU - Roethig,Hans J, AU - Mendes,Paul, AU - Unverdorben,Martin, Y1 - 2009/07/10/ PY - 2009/7/14/entrez PY - 2009/7/14/pubmed PY - 2009/10/7/medline SP - 192 EP - 8 JF - Journal of cardiovascular pharmacology and therapeutics JO - J Cardiovasc Pharmacol Ther VL - 14 IS - 3 N2 - BACKGROUND: Smoking has been shown to influence the tone of the autonomic nervous system as reflected by heart rate variability (HRV). To date, no information is available as to whether 24-hour HRV might differentiate users of different tobacco products. OBJECTIVE: To assess the differences in HRV derived from the 24-hour electrocardiogram (ECG) following the use of 2 tobacco products of potentially different exposures. METHODS: Thirty adult Caucasian male smokers (mean age: 42.8 + 5.7 years) smoking 20 to 40 cigarettes/ day were randomized in a 3-way crossover study design to either smoke a conventional cigarette (CC, tar: 11 mg, Nic: 0.8 mg), to use the Electrically Heated Cigarette Smoking System (EHCSS: tar: 5 mg, Nic: 0.3 mg, according to the Federal Trade Commission [FTC]), or to stop smoking (NS) for 3 days each. The 24 hours ECGs were recorded during the last 24 hours of each exposure period. RESULTS: A 24-hour ECG showed highest mean values for standard deviation of all normal-to-normal heart beat (NN) intervals (SDNN), standard deviation of all 5-minute averaged NN intervals in a 24-hour period (SDANN), mean of the standard deviations of the NN intervals calculated from all 5-minute segments in a 24-hour period (SDNNI), percentage (P) of all NN intervals that differ by 50 milliseconds of all NN (PNN50%), the square root of the mean of all squared differences between adjacent NN intervals in 24-hour period (RMSSD), and total number of all NN intervals divided by the height of the histogram of all NN intervals measured on a discrete scale with bins of 7 x 8125 ms (1/128 seconds; HRVTI) when participants stopped smoking followed by the use of the reduced exposure product and CC. CONCLUSION: Heart rate variability tended to increase with reduced smoke exposure. SN - 1074-2484 UR - https://www.unboundmedicine.com/medline/citation/19592602/Heart_rate_variability_increases_with_reductions_in_cigarette_smoke_exposure_after_3_days_ L2 - https://journals.sagepub.com/doi/10.1177/1074248409340340?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -