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Hypertriglyceridemic waist phenotype predicts increased visceral fat in subjects with type 2 diabetes.
Diabetes Care. 2009 Oct; 32(10):1916-20.DC

Abstract

OBJECTIVE

Greater accumulation of visceral fat is strongly linked to risk of cardiovascular disease. However, elevated waist circumference by itself does not always identify individuals with increased visceral fat.

RESEARCH DESIGN AND METHODS

We examined 375 subjects with type 2 diabetes from the CHICAGO cohort for presence of hypertriglyceridemic waist phenotype (waist circumference >90 cm in men or >85 cm in women, in conjunction with a plasma triglyceride concentration of > or =177 mg/dl) to determine its usefulness for identifying subjects with increased amounts of visceral fat. We divided subjects into three groups: group 1 (low waist circumference and low triglycerides; waist circumference < or =90 cm in men or < or =85 cm in women and triglyceride <177 mg/dl, n = 18), group 2 (high waist circumference and low triglycerides; waist circumference >90 cm in men or >85 cm in women and triglycerides <177 mg/dl, n = 230), and group 3 (high waist circumference and high triglycerides; waist circumference >90 cm in men or >85 cm in women and triglycerides > or =177 mg/dl, n = 127).

RESULTS

Subjects in group 3 had significantly higher visceral fat (P < 0.0001), A1C (P < 0.01), and coronary artery calcium (P < 0.05) compared with group 2, despite similar age, BMI, and waist circumference. The relationship of the phenotype to atherosclerosis, however, was attenuated by adjustment for HDL cholesterol, triglyceride-rich lipoprotein cholesterol, apolipoprotein B, or LDL particle number.

CONCLUSIONS

The presence of hypertriglyceridemic waist phenotype in subjects with type 2 diabetes identifies a subset with greater degree of visceral adiposity. This subset also has greater degree of subclinical atherosclerosis that may be related to the proatherogenic lipoprotein changes.

Authors+Show Affiliations

Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, University of Illinois, Chicago, Illinois. susansam@uic.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19592623

Citation

Sam, Susan, et al. "Hypertriglyceridemic Waist Phenotype Predicts Increased Visceral Fat in Subjects With Type 2 Diabetes." Diabetes Care, vol. 32, no. 10, 2009, pp. 1916-20.
Sam S, Haffner S, Davidson MH, et al. Hypertriglyceridemic waist phenotype predicts increased visceral fat in subjects with type 2 diabetes. Diabetes Care. 2009;32(10):1916-20.
Sam, S., Haffner, S., Davidson, M. H., D'Agostino, R. B., Feinstein, S., Kondos, G., Perez, A., & Mazzone, T. (2009). Hypertriglyceridemic waist phenotype predicts increased visceral fat in subjects with type 2 diabetes. Diabetes Care, 32(10), 1916-20. https://doi.org/10.2337/dc09-0412
Sam S, et al. Hypertriglyceridemic Waist Phenotype Predicts Increased Visceral Fat in Subjects With Type 2 Diabetes. Diabetes Care. 2009;32(10):1916-20. PubMed PMID: 19592623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypertriglyceridemic waist phenotype predicts increased visceral fat in subjects with type 2 diabetes. AU - Sam,Susan, AU - Haffner,Steven, AU - Davidson,Michael H, AU - D'Agostino,Ralph B,Sr AU - Feinstein,Steven, AU - Kondos,George, AU - Perez,Alfonso, AU - Mazzone,Theodore, Y1 - 2009/07/10/ PY - 2009/7/14/entrez PY - 2009/7/14/pubmed PY - 2009/12/30/medline SP - 1916 EP - 20 JF - Diabetes care JO - Diabetes Care VL - 32 IS - 10 N2 - OBJECTIVE: Greater accumulation of visceral fat is strongly linked to risk of cardiovascular disease. However, elevated waist circumference by itself does not always identify individuals with increased visceral fat. RESEARCH DESIGN AND METHODS: We examined 375 subjects with type 2 diabetes from the CHICAGO cohort for presence of hypertriglyceridemic waist phenotype (waist circumference >90 cm in men or >85 cm in women, in conjunction with a plasma triglyceride concentration of > or =177 mg/dl) to determine its usefulness for identifying subjects with increased amounts of visceral fat. We divided subjects into three groups: group 1 (low waist circumference and low triglycerides; waist circumference < or =90 cm in men or < or =85 cm in women and triglyceride <177 mg/dl, n = 18), group 2 (high waist circumference and low triglycerides; waist circumference >90 cm in men or >85 cm in women and triglycerides <177 mg/dl, n = 230), and group 3 (high waist circumference and high triglycerides; waist circumference >90 cm in men or >85 cm in women and triglycerides > or =177 mg/dl, n = 127). RESULTS: Subjects in group 3 had significantly higher visceral fat (P < 0.0001), A1C (P < 0.01), and coronary artery calcium (P < 0.05) compared with group 2, despite similar age, BMI, and waist circumference. The relationship of the phenotype to atherosclerosis, however, was attenuated by adjustment for HDL cholesterol, triglyceride-rich lipoprotein cholesterol, apolipoprotein B, or LDL particle number. CONCLUSIONS: The presence of hypertriglyceridemic waist phenotype in subjects with type 2 diabetes identifies a subset with greater degree of visceral adiposity. This subset also has greater degree of subclinical atherosclerosis that may be related to the proatherogenic lipoprotein changes. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/19592623/Hypertriglyceridemic_waist_phenotype_predicts_increased_visceral_fat_in_subjects_with_type_2_diabetes_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=19592623 DB - PRIME DP - Unbound Medicine ER -