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[Effect of admission blood glucose levels on the short term mortality in patients with acute ST-segment elevation myocardial infarction].
Zhonghua Yi Xue Za Zhi 2009; 89(18):1230-3ZY

Abstract

OBJECTIVE

To evaluate the predictive value of different admission blood glucose levels for short-term mortality in patients with ST-segment elevation acute myocardial infarction (STEMI).

METHOD

An observational analysis of 7446 Chinese STEMI patients from a global randomized controlled trials were recruited within 12 hours of symptom onset. According to the levels of admission glucose, these patients were divided into six groups, admission glucose < 4.50 mmol/L was defined as the hypoglycemia group; glucose of 4.5 - 5.5 mmol/L a control; 5.6 - 7.0 mmol/L, 7.1 - 8.5 mmol/L (mild hyperglycemia group) and 8.6 - 11.0 mmol/L (moderate hyperglycemia group); glucose > 11.0 mmol/L was the severe hyperglycemia group. The 30-day mortality was analyzed.

RESULT

Compared with the glucose of 4.5 - 5.5 mmol/L group, thirty-day mortality increased in patients with hypoglycemia (10.2%, P < 0.05), mild and moderate hyperglycemia (9.2%, P = 0.01; 11.6%, P < 0.01, respectively) and severe hyperglycemia (18.6%, P < 0.01). The highest mortality occurred in the severe hyperglycemia group. Multivariate logistic regression analysis showed that, as compared with glucose of 4.5 - 5.5 mmol/L, the mild and the moderate hyperglycemia groups had a mortality increasing of 46% (OR 1.46, 95% CI 1.03 - 2.07, P = 0.01) and 58% fold (OR 1.58, 95% CI 1.13 - 2.22 P = 0.02) respectively; the severe hyperglycemia group had a risk of death of 2.26 folds (OR 2.26, 95% CI 1.62 - 3.14, P = 0.05). Mild, moderate and severe hyperglycemia were independent predictors of 30-day mortality.

CONCLUSION

The 30-day mortality was higher in STEMI patients with mild, moderate and severe hyperglycemia at admission. Admission blood glucose level is an important factor associated with a short-term.

Authors+Show Affiliations

Cardiovascular Institute and Fu Wai Heart Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

19595174

Citation

Yang, Yan-Min, et al. "[Effect of Admission Blood Glucose Levels On the Short Term Mortality in Patients With Acute ST-segment Elevation Myocardial Infarction]." Zhonghua Yi Xue Za Zhi, vol. 89, no. 18, 2009, pp. 1230-3.
Yang YM, Liu Y, Zhu J, et al. [Effect of admission blood glucose levels on the short term mortality in patients with acute ST-segment elevation myocardial infarction]. Zhonghua Yi Xue Za Zhi. 2009;89(18):1230-3.
Yang, Y. M., Liu, Y., Zhu, J., Tan, H. Q., Liang, Y., Li, Y., ... Liu, L. S. (2009). [Effect of admission blood glucose levels on the short term mortality in patients with acute ST-segment elevation myocardial infarction]. Zhonghua Yi Xue Za Zhi, 89(18), pp. 1230-3.
Yang YM, et al. [Effect of Admission Blood Glucose Levels On the Short Term Mortality in Patients With Acute ST-segment Elevation Myocardial Infarction]. Zhonghua Yi Xue Za Zhi. 2009 May 12;89(18):1230-3. PubMed PMID: 19595174.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of admission blood glucose levels on the short term mortality in patients with acute ST-segment elevation myocardial infarction]. AU - Yang,Yan-Min, AU - Liu,Yao, AU - Zhu,Jun, AU - Tan,Hui-Qiong, AU - Liang,Yan, AU - Li,Ying, AU - Li,Jian-Dong, AU - Zhang,Yan, AU - Liu,Li-Sheng, PY - 2009/7/15/entrez PY - 2009/7/15/pubmed PY - 2009/11/18/medline SP - 1230 EP - 3 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 89 IS - 18 N2 - OBJECTIVE: To evaluate the predictive value of different admission blood glucose levels for short-term mortality in patients with ST-segment elevation acute myocardial infarction (STEMI). METHOD: An observational analysis of 7446 Chinese STEMI patients from a global randomized controlled trials were recruited within 12 hours of symptom onset. According to the levels of admission glucose, these patients were divided into six groups, admission glucose < 4.50 mmol/L was defined as the hypoglycemia group; glucose of 4.5 - 5.5 mmol/L a control; 5.6 - 7.0 mmol/L, 7.1 - 8.5 mmol/L (mild hyperglycemia group) and 8.6 - 11.0 mmol/L (moderate hyperglycemia group); glucose > 11.0 mmol/L was the severe hyperglycemia group. The 30-day mortality was analyzed. RESULT: Compared with the glucose of 4.5 - 5.5 mmol/L group, thirty-day mortality increased in patients with hypoglycemia (10.2%, P < 0.05), mild and moderate hyperglycemia (9.2%, P = 0.01; 11.6%, P < 0.01, respectively) and severe hyperglycemia (18.6%, P < 0.01). The highest mortality occurred in the severe hyperglycemia group. Multivariate logistic regression analysis showed that, as compared with glucose of 4.5 - 5.5 mmol/L, the mild and the moderate hyperglycemia groups had a mortality increasing of 46% (OR 1.46, 95% CI 1.03 - 2.07, P = 0.01) and 58% fold (OR 1.58, 95% CI 1.13 - 2.22 P = 0.02) respectively; the severe hyperglycemia group had a risk of death of 2.26 folds (OR 2.26, 95% CI 1.62 - 3.14, P = 0.05). Mild, moderate and severe hyperglycemia were independent predictors of 30-day mortality. CONCLUSION: The 30-day mortality was higher in STEMI patients with mild, moderate and severe hyperglycemia at admission. Admission blood glucose level is an important factor associated with a short-term. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/19595174/[Effect_of_admission_blood_glucose_levels_on_the_short_term_mortality_in_patients_with_acute_ST_segment_elevation_myocardial_infarction]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0376-2491&amp;year=2009&amp;vol=89&amp;issue=18&amp;fpage=1230 DB - PRIME DP - Unbound Medicine ER -