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[Evaluation of preferences in patients with gastroesophageal reflux disease and dysphagia concerning treatment with lansoprazole orally disintegrating tablets].
Gastroenterol Hepatol. 2009 Oct; 32(8):542-8.GH

Abstract

INTRODUCTION AND OBJECTIVE

Recently, a new lansoprazole formulation consisting of orally disintegrating tablets has become available, which could improve acceptability and compliance with this type of medication. The aim of the present study was to evaluate preferences in patients with gastroesophageal reflux disease concerning lansoprazole orally disintegrating tablets compared with lansoprazole capsules.

MATERIAL AND METHODS

A phase IV, multicenter, crossed, open and randomized clinical trial was performed in patients with symptoms of gastroesophageal reflux disease and associated dysphagia. The patients were treated with 30mg lansoprazole capsules for 3 days and with 30mg lansoprazole orally disintegrating tablets for another 3 days. The order of treatment (first capsules followed by orally disintegrating tablets or vice versa) was determined by centralized block randomization. The main measure was the visual analog scale (VAS) score in which patients was asked to rate their degree of preference for the orally disintegrating tablets or the capsules.

RESULTS

Of the 145 patients included, 126 could be evaluated by the protocol. A total of 47% (59/126) of the patients preferred the orally disintegrating tablets, 33% (42/126) preferred the capsules and the remainder (25/126) had no preference. The mean preference value in the VAS was 5.31 (4.72 +/- 5.90) in favor of the orally disintegrating tablets, although this difference was not statistically significant. In general, differences in favor of the orally disintegrating tables were more marked in older patients. The percentage of patients free of pyrosis at the end of both treatment sequences was approximately 75% with no differences according to which treatment was administered first. Finally, preference evaluation through willingness to pay techniques showed similar results, again in favor of the orally disintegrating tablets (4.18 euro +/- 6.86 euro vs 3.47 euro +/- 5.78 euro).

CONCLUSION

The acceptability of pharmaceutical formulations of lansoprazole in capsules and orally disintegrating tables is similar among patients with gastroesophageal reflux disease and associated dysphagia. However, a clear, but nonsignificant, trend was observed in favor of orally disintegrating tablets among older patients.

Authors+Show Affiliations

Servicio de Gastroenterología, Hospital Virgen de la Torre, Madrid, España.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial, Phase IV
English Abstract
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

spa

PubMed ID

19595483

Citation

Blanco, María Angeles, et al. "[Evaluation of Preferences in Patients With Gastroesophageal Reflux Disease and Dysphagia Concerning Treatment With Lansoprazole Orally Disintegrating Tablets]." Gastroenterologia Y Hepatologia, vol. 32, no. 8, 2009, pp. 542-8.
Blanco MA, Prieto M, Mearin F, et al. [Evaluation of preferences in patients with gastroesophageal reflux disease and dysphagia concerning treatment with lansoprazole orally disintegrating tablets]. Gastroenterol Hepatol. 2009;32(8):542-8.
Blanco, M. A., Prieto, M., Mearin, F., Plazas, M. J., Armengol, S., Heras, J., Mas, M., & Piqué, J. M. (2009). [Evaluation of preferences in patients with gastroesophageal reflux disease and dysphagia concerning treatment with lansoprazole orally disintegrating tablets]. Gastroenterologia Y Hepatologia, 32(8), 542-8. https://doi.org/10.1016/j.gastrohep.2009.05.004
Blanco MA, et al. [Evaluation of Preferences in Patients With Gastroesophageal Reflux Disease and Dysphagia Concerning Treatment With Lansoprazole Orally Disintegrating Tablets]. Gastroenterol Hepatol. 2009;32(8):542-8. PubMed PMID: 19595483.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Evaluation of preferences in patients with gastroesophageal reflux disease and dysphagia concerning treatment with lansoprazole orally disintegrating tablets]. AU - Blanco,María Angeles, AU - Prieto,Miguel, AU - Mearin,Fermín, AU - Plazas,María José, AU - Armengol,Silvia, AU - Heras,Joan, AU - Mas,Marta, AU - Piqué,Josep M, AU - ,, PY - 2009/05/11/received PY - 2009/05/27/accepted PY - 2009/7/15/entrez PY - 2009/7/15/pubmed PY - 2010/1/27/medline SP - 542 EP - 8 JF - Gastroenterologia y hepatologia JO - Gastroenterol Hepatol VL - 32 IS - 8 N2 - INTRODUCTION AND OBJECTIVE: Recently, a new lansoprazole formulation consisting of orally disintegrating tablets has become available, which could improve acceptability and compliance with this type of medication. The aim of the present study was to evaluate preferences in patients with gastroesophageal reflux disease concerning lansoprazole orally disintegrating tablets compared with lansoprazole capsules. MATERIAL AND METHODS: A phase IV, multicenter, crossed, open and randomized clinical trial was performed in patients with symptoms of gastroesophageal reflux disease and associated dysphagia. The patients were treated with 30mg lansoprazole capsules for 3 days and with 30mg lansoprazole orally disintegrating tablets for another 3 days. The order of treatment (first capsules followed by orally disintegrating tablets or vice versa) was determined by centralized block randomization. The main measure was the visual analog scale (VAS) score in which patients was asked to rate their degree of preference for the orally disintegrating tablets or the capsules. RESULTS: Of the 145 patients included, 126 could be evaluated by the protocol. A total of 47% (59/126) of the patients preferred the orally disintegrating tablets, 33% (42/126) preferred the capsules and the remainder (25/126) had no preference. The mean preference value in the VAS was 5.31 (4.72 +/- 5.90) in favor of the orally disintegrating tablets, although this difference was not statistically significant. In general, differences in favor of the orally disintegrating tables were more marked in older patients. The percentage of patients free of pyrosis at the end of both treatment sequences was approximately 75% with no differences according to which treatment was administered first. Finally, preference evaluation through willingness to pay techniques showed similar results, again in favor of the orally disintegrating tablets (4.18 euro +/- 6.86 euro vs 3.47 euro +/- 5.78 euro). CONCLUSION: The acceptability of pharmaceutical formulations of lansoprazole in capsules and orally disintegrating tables is similar among patients with gastroesophageal reflux disease and associated dysphagia. However, a clear, but nonsignificant, trend was observed in favor of orally disintegrating tablets among older patients. SN - 0210-5705 UR - https://www.unboundmedicine.com/medline/citation/19595483/[Evaluation_of_preferences_in_patients_with_gastroesophageal_reflux_disease_and_dysphagia_concerning_treatment_with_lansoprazole_orally_disintegrating_tablets]_ L2 - http://www.elsevier.es/en/linksolver/ft/pii/S0210-5705(09)00436-1 DB - PRIME DP - Unbound Medicine ER -