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Peony glycosides produce antidepressant-like action in mice exposed to chronic unpredictable mild stress: effects on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor.
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Oct 01; 33(7):1211-6.PN

Abstract

The root part of Paeonia lactiflora Pall. (Ranunculaceae), commonly known as peony, is a commonly used Chinese herb for the treatment of depression-like disorders. Previous studies in our laboratory have demonstrated that total glycosides of peony (TGP) produced antidepressant-like action in various mouse models of behavioral despair. The present study aimed to examine whether TGP could affect the chronic unpredictable mild stress (CUMS)-induced depression in mice. The mechanism(s) underlying the antidepressant-like action was investigated by measuring serum corticosterone level, glucocorticoid receptor (GR) and brain-derived neurotrophic factor (BDNF) mRNA levels in brain tissues. CUMS, being lasted for 6 weeks, caused depression-like behavior in mice, as indicated by the significant decrease in sucrose consumption and increase in immobility time in the forced swim test. Whereas serum corticosterone level was significantly increased in mice exposed to CUMS, expressions of GR mRNA in hippocampus, and BDNF mRNA in hippocampus and frontal cortex, were decreased in CUMS-treated mice. Daily intragastric administration of TGP (80 or 160 mg/kg/day) during the six weeks of CUMS significantly suppressed behavioral and biochemical changes induced by CUMS. The results suggest that the antidepressant-like action of TPG is likely mediated by modulating the function of hypothalamic-pituitary-adrenal axis and increasing the expression of BDNF in brain tissues.

Authors+Show Affiliations

School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19596036

Citation

Mao, Qing-Qiu, et al. "Peony Glycosides Produce Antidepressant-like Action in Mice Exposed to Chronic Unpredictable Mild Stress: Effects On Hypothalamic-pituitary-adrenal Function and Brain-derived Neurotrophic Factor." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 33, no. 7, 2009, pp. 1211-6.
Mao QQ, Ip SP, Ko KM, et al. Peony glycosides produce antidepressant-like action in mice exposed to chronic unpredictable mild stress: effects on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(7):1211-6.
Mao, Q. Q., Ip, S. P., Ko, K. M., Tsai, S. H., & Che, C. T. (2009). Peony glycosides produce antidepressant-like action in mice exposed to chronic unpredictable mild stress: effects on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor. Progress in Neuro-psychopharmacology & Biological Psychiatry, 33(7), 1211-6. https://doi.org/10.1016/j.pnpbp.2009.07.002
Mao QQ, et al. Peony Glycosides Produce Antidepressant-like Action in Mice Exposed to Chronic Unpredictable Mild Stress: Effects On Hypothalamic-pituitary-adrenal Function and Brain-derived Neurotrophic Factor. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Oct 1;33(7):1211-6. PubMed PMID: 19596036.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peony glycosides produce antidepressant-like action in mice exposed to chronic unpredictable mild stress: effects on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor. AU - Mao,Qing-Qiu, AU - Ip,Siu-Po, AU - Ko,Kam-Ming, AU - Tsai,Sam-Hip, AU - Che,Chun-Tao, Y1 - 2009/07/21/ PY - 2009/03/24/received PY - 2009/06/11/revised PY - 2009/07/02/accepted PY - 2009/7/15/entrez PY - 2009/7/15/pubmed PY - 2009/11/18/medline SP - 1211 EP - 6 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog. Neuropsychopharmacol. Biol. Psychiatry VL - 33 IS - 7 N2 - The root part of Paeonia lactiflora Pall. (Ranunculaceae), commonly known as peony, is a commonly used Chinese herb for the treatment of depression-like disorders. Previous studies in our laboratory have demonstrated that total glycosides of peony (TGP) produced antidepressant-like action in various mouse models of behavioral despair. The present study aimed to examine whether TGP could affect the chronic unpredictable mild stress (CUMS)-induced depression in mice. The mechanism(s) underlying the antidepressant-like action was investigated by measuring serum corticosterone level, glucocorticoid receptor (GR) and brain-derived neurotrophic factor (BDNF) mRNA levels in brain tissues. CUMS, being lasted for 6 weeks, caused depression-like behavior in mice, as indicated by the significant decrease in sucrose consumption and increase in immobility time in the forced swim test. Whereas serum corticosterone level was significantly increased in mice exposed to CUMS, expressions of GR mRNA in hippocampus, and BDNF mRNA in hippocampus and frontal cortex, were decreased in CUMS-treated mice. Daily intragastric administration of TGP (80 or 160 mg/kg/day) during the six weeks of CUMS significantly suppressed behavioral and biochemical changes induced by CUMS. The results suggest that the antidepressant-like action of TPG is likely mediated by modulating the function of hypothalamic-pituitary-adrenal axis and increasing the expression of BDNF in brain tissues. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/19596036/Peony_glycosides_produce_antidepressant_like_action_in_mice_exposed_to_chronic_unpredictable_mild_stress:_effects_on_hypothalamic_pituitary_adrenal_function_and_brain_derived_neurotrophic_factor_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(09)00216-4 DB - PRIME DP - Unbound Medicine ER -