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Long lasting immunity in chickens induced by a single shot of influenza vaccine prepared from inactivated non-pathogenic H5N1 virus particles against challenge with a highly pathogenic avian influenza virus.
Vaccine. 2009 Aug 20; 27(38):5174-7.V

Abstract

An influenza vaccine was prepared from inactivated whole particles of the non-pathogenic strain A/duck/Hokkaido/Vac-1/04 (H5N1) virus using an oil adjuvant containing anhydromannitol-octadecenoate-ether (AMOE). The vaccine was injected intramuscularly into five 4-week-old chickens, and 138 weeks after vaccination, they were challenged intranasally with 100 times 50% chicken lethal dose of the highly pathogenic avian influenza (HPAI) virus A/chicken/Yamaguchi/7/04 (H5N1). All 5 chickens survived without exhibiting clinical signs of influenza, although 2 days post-challenge, 3 vaccinated chickens shed limited titres of viruses in laryngopharyngeal swabs.

Authors+Show Affiliations

Avian Biologics Department, Kyoto Biken Laboratories, Inc., 24-16 Makishima-cho, Uji, Kyoto 611-0041, Japan. keibyou_one@kyotobiken.co.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19596414

Citation

Sasaki, Takashi, et al. "Long Lasting Immunity in Chickens Induced By a Single Shot of Influenza Vaccine Prepared From Inactivated Non-pathogenic H5N1 Virus Particles Against Challenge With a Highly Pathogenic Avian Influenza Virus." Vaccine, vol. 27, no. 38, 2009, pp. 5174-7.
Sasaki T, Kokumai N, Ohgitani T, et al. Long lasting immunity in chickens induced by a single shot of influenza vaccine prepared from inactivated non-pathogenic H5N1 virus particles against challenge with a highly pathogenic avian influenza virus. Vaccine. 2009;27(38):5174-7.
Sasaki, T., Kokumai, N., Ohgitani, T., Sakamoto, R., Takikawa, N., Lin, Z., Okamatsu, M., Sakoda, Y., & Kida, H. (2009). Long lasting immunity in chickens induced by a single shot of influenza vaccine prepared from inactivated non-pathogenic H5N1 virus particles against challenge with a highly pathogenic avian influenza virus. Vaccine, 27(38), 5174-7. https://doi.org/10.1016/j.vaccine.2009.06.070
Sasaki T, et al. Long Lasting Immunity in Chickens Induced By a Single Shot of Influenza Vaccine Prepared From Inactivated Non-pathogenic H5N1 Virus Particles Against Challenge With a Highly Pathogenic Avian Influenza Virus. Vaccine. 2009 Aug 20;27(38):5174-7. PubMed PMID: 19596414.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long lasting immunity in chickens induced by a single shot of influenza vaccine prepared from inactivated non-pathogenic H5N1 virus particles against challenge with a highly pathogenic avian influenza virus. AU - Sasaki,Takashi, AU - Kokumai,Norihide, AU - Ohgitani,Toshiaki, AU - Sakamoto,Ryuichi, AU - Takikawa,Noriyasu, AU - Lin,Zhifeng, AU - Okamatsu,Masatoshi, AU - Sakoda,Yoshihiro, AU - Kida,Hiroshi, Y1 - 2009/07/09/ PY - 2009/05/12/received PY - 2009/06/12/revised PY - 2009/06/22/accepted PY - 2009/7/15/entrez PY - 2009/7/15/pubmed PY - 2009/9/18/medline SP - 5174 EP - 7 JF - Vaccine JO - Vaccine VL - 27 IS - 38 N2 - An influenza vaccine was prepared from inactivated whole particles of the non-pathogenic strain A/duck/Hokkaido/Vac-1/04 (H5N1) virus using an oil adjuvant containing anhydromannitol-octadecenoate-ether (AMOE). The vaccine was injected intramuscularly into five 4-week-old chickens, and 138 weeks after vaccination, they were challenged intranasally with 100 times 50% chicken lethal dose of the highly pathogenic avian influenza (HPAI) virus A/chicken/Yamaguchi/7/04 (H5N1). All 5 chickens survived without exhibiting clinical signs of influenza, although 2 days post-challenge, 3 vaccinated chickens shed limited titres of viruses in laryngopharyngeal swabs. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/19596414/Long_lasting_immunity_in_chickens_induced_by_a_single_shot_of_influenza_vaccine_prepared_from_inactivated_non_pathogenic_H5N1_virus_particles_against_challenge_with_a_highly_pathogenic_avian_influenza_virus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(09)00957-8 DB - PRIME DP - Unbound Medicine ER -