Tags

Type your tag names separated by a space and hit enter

Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation.
J Hepatol 2009; 51(3):528-34JH

Abstract

BACKGROUND/AIMS

The endocannabinoid system in mice plays a role in models of human cirrhosis and hepatic encephalopathy (HE), induced by a hepatotoxin. We report now the therapeutic effects of cannabidiol (CBD), a non-psychoactive constituent of Cannabis sativa, on HE caused by bile duct ligation (BDL), a model of chronic liver disease.

METHODS

CBD (5mg/kg; i.p.) was administered over 4weeks to mice that had undergone BDL.

RESULTS

Cognitive function in the eight arm maze and the T-maze tests, as well as locomotor function in the open field test were impaired by the ligation and were improved by CBD. BDL raised hippocampal expression of the TNF-alpha-receptor 1 gene, which was reduced by CBD. However, BDL reduced expression of the brain-derived neurotrophic factor (BDNF) gene, which was increased by CBD. The effects of CBD on cognition, locomotion and on TNF-alpha receptor 1 expression were blocked by ZM241385, an A(2)A adenosine receptor antagonist. BDL lowers the expression of this receptor.

CONCLUSIONS

The effects of BDL apparently result in part from down-regulation of A(2)A adenosine receptor. CBD reverses these effects through activation of this receptor, leading to compensation of the ligation effect.

Authors+Show Affiliations

Department of Human Nutrition and Metabolism, Braun's School of Public Health, Hadassah-Hebrew University Medical Faculty, 91120 Jerusalem, Israel.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19596476

Citation

Magen, Iddo, et al. "Cannabidiol Ameliorates Cognitive and Motor Impairments in Mice With Bile Duct Ligation." Journal of Hepatology, vol. 51, no. 3, 2009, pp. 528-34.
Magen I, Avraham Y, Ackerman Z, et al. Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation. J Hepatol. 2009;51(3):528-34.
Magen, I., Avraham, Y., Ackerman, Z., Vorobiev, L., Mechoulam, R., & Berry, E. M. (2009). Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation. Journal of Hepatology, 51(3), pp. 528-34. doi:10.1016/j.jhep.2009.04.021.
Magen I, et al. Cannabidiol Ameliorates Cognitive and Motor Impairments in Mice With Bile Duct Ligation. J Hepatol. 2009;51(3):528-34. PubMed PMID: 19596476.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation. AU - Magen,Iddo, AU - Avraham,Yosefa, AU - Ackerman,Zvi, AU - Vorobiev,Lia, AU - Mechoulam,Raphael, AU - Berry,Elliot M, Y1 - 2009/05/27/ PY - 2008/08/12/received PY - 2009/03/18/revised PY - 2009/04/06/accepted PY - 2009/7/15/entrez PY - 2009/7/15/pubmed PY - 2010/1/28/medline SP - 528 EP - 34 JF - Journal of hepatology JO - J. Hepatol. VL - 51 IS - 3 N2 - BACKGROUND/AIMS: The endocannabinoid system in mice plays a role in models of human cirrhosis and hepatic encephalopathy (HE), induced by a hepatotoxin. We report now the therapeutic effects of cannabidiol (CBD), a non-psychoactive constituent of Cannabis sativa, on HE caused by bile duct ligation (BDL), a model of chronic liver disease. METHODS: CBD (5mg/kg; i.p.) was administered over 4weeks to mice that had undergone BDL. RESULTS: Cognitive function in the eight arm maze and the T-maze tests, as well as locomotor function in the open field test were impaired by the ligation and were improved by CBD. BDL raised hippocampal expression of the TNF-alpha-receptor 1 gene, which was reduced by CBD. However, BDL reduced expression of the brain-derived neurotrophic factor (BDNF) gene, which was increased by CBD. The effects of CBD on cognition, locomotion and on TNF-alpha receptor 1 expression were blocked by ZM241385, an A(2)A adenosine receptor antagonist. BDL lowers the expression of this receptor. CONCLUSIONS: The effects of BDL apparently result in part from down-regulation of A(2)A adenosine receptor. CBD reverses these effects through activation of this receptor, leading to compensation of the ligation effect. SN - 1600-0641 UR - https://www.unboundmedicine.com/medline/citation/19596476/abstract/Cannabidiol_ameliorates_cognitive_and_motor_impairments_in_mice_with_bile_duct_ligation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8278(09)00373-0 DB - PRIME DP - Unbound Medicine ER -