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Use of supplements of multivitamins, vitamin C, and vitamin E in relation to mortality.

Abstract

In this cohort study, the authors evaluated how supplemental use of multivitamins, vitamin C, and vitamin E over a 10-year period was related to 5-year total mortality, cancer mortality, and cardiovascular disease (CVD) mortality. Participants (n = 77,719) were Washington State residents aged 50-76 years who completed a mailed self-administered questionnaire in 2000-2002. Adjusted hazard ratios and 95% confidence intervals were computed using Cox regression. Multivitamin use was not related to total mortality. However, vitamin C and vitamin E use were associated with small decreases in risk. In cause-specific analyses, use of multivitamins and use of vitamin E were associated with decreased risks of CVD mortality. The hazard ratio comparing persons who had a 10-year average frequency of multivitamin use of 6-7 days per week with nonusers was 0.84 (95% confidence interval: 0.70, 0.99); and the hazard ratio comparing persons who had a 10-year average daily dose of vitamin E greater than 215 mg with nonusers was 0.72 (95% confidence interval: 0.59, 0.88). In contrast, vitamin C use was not associated with CVD mortality. Multivitamin and vitamin E use were not associated with cancer mortality. Some of the associations we observed were small and may have been due to unmeasured healthy behaviors that were more common in supplement users.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, University of Washington, Seattle, USA. gpocobel@u.washington.edu

    , ,

    Source

    American journal of epidemiology 170:4 2009 Aug 15 pg 472-83

    MeSH

    Aged
    Ascorbic Acid
    Cardiovascular Diseases
    Cohort Studies
    Dietary Supplements
    Follow-Up Studies
    Humans
    Middle Aged
    Mortality
    Neoplasms
    Proportional Hazards Models
    Vitamin E
    Vitamins
    Washington

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19596711

    Citation

    Pocobelli, Gaia, et al. "Use of Supplements of Multivitamins, Vitamin C, and Vitamin E in Relation to Mortality." American Journal of Epidemiology, vol. 170, no. 4, 2009, pp. 472-83.
    Pocobelli G, Peters U, Kristal AR, et al. Use of supplements of multivitamins, vitamin C, and vitamin E in relation to mortality. Am J Epidemiol. 2009;170(4):472-83.
    Pocobelli, G., Peters, U., Kristal, A. R., & White, E. (2009). Use of supplements of multivitamins, vitamin C, and vitamin E in relation to mortality. American Journal of Epidemiology, 170(4), pp. 472-83. doi:10.1093/aje/kwp167.
    Pocobelli G, et al. Use of Supplements of Multivitamins, Vitamin C, and Vitamin E in Relation to Mortality. Am J Epidemiol. 2009 Aug 15;170(4):472-83. PubMed PMID: 19596711.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Use of supplements of multivitamins, vitamin C, and vitamin E in relation to mortality. AU - Pocobelli,Gaia, AU - Peters,Ulrike, AU - Kristal,Alan R, AU - White,Emily, Y1 - 2009/07/13/ PY - 2009/7/15/entrez PY - 2009/7/15/pubmed PY - 2009/8/12/medline SP - 472 EP - 83 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 170 IS - 4 N2 - In this cohort study, the authors evaluated how supplemental use of multivitamins, vitamin C, and vitamin E over a 10-year period was related to 5-year total mortality, cancer mortality, and cardiovascular disease (CVD) mortality. Participants (n = 77,719) were Washington State residents aged 50-76 years who completed a mailed self-administered questionnaire in 2000-2002. Adjusted hazard ratios and 95% confidence intervals were computed using Cox regression. Multivitamin use was not related to total mortality. However, vitamin C and vitamin E use were associated with small decreases in risk. In cause-specific analyses, use of multivitamins and use of vitamin E were associated with decreased risks of CVD mortality. The hazard ratio comparing persons who had a 10-year average frequency of multivitamin use of 6-7 days per week with nonusers was 0.84 (95% confidence interval: 0.70, 0.99); and the hazard ratio comparing persons who had a 10-year average daily dose of vitamin E greater than 215 mg with nonusers was 0.72 (95% confidence interval: 0.59, 0.88). In contrast, vitamin C use was not associated with CVD mortality. Multivitamin and vitamin E use were not associated with cancer mortality. Some of the associations we observed were small and may have been due to unmeasured healthy behaviors that were more common in supplement users. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/19596711/Use_of_supplements_of_multivitamins_vitamin_C_and_vitamin_E_in_relation_to_mortality_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwp167 DB - PRIME DP - Unbound Medicine ER -