Tags

Type your tag names separated by a space and hit enter

Hepatitis B virus and hepatitis C virus dual infection among patients with chronic liver disease.
J Microbiol Immunol Infect. 2009 Apr; 42(2):122-8.JM

Abstract

BACKGROUND AND PURPOSE

Hepatitis B virus (HBV) and hepatitis C virus (HCV) dual infection accounts for a substantial proportion of liver diseases worldwide. Although the exact prevalence is not known, these viral infections are common among patients with chronic liver disease (CLD). This study was performed to determine the prevalence of HBV and HCV dual infection among patients with CLD in Chennai, India.

METHODS

251 patients were tested for the presence of hepatitis B surface antigen (HBsAg), immunoglobulin (Ig)-M/IgG antibody to hepatitis B core antigen (anti-HBc) and anti-HCV antibodies, and HBV-DNA and HCV-RNA by qualitative polymerase chain reaction.

RESULTS

Coinfection with HCV and HBV was detected in 15 patients (5.9%), 12 of whom (80.0%) were positive for HCV-RNA and IgG anti-HBc with no evidence of HBV-DNA, while 3 HBsAg-negative patients (20.0%) were positive for HBV-DNA in addition to HCV-RNA. Liver function test profiles were significantly altered for HCV-positive patients compared with HBV-positive and HBV/HCV coinfected patients (p = 0.001). Bilirubin and alanine aminotransferase levels were significantly raised in coinfected patients compared with non-HBV, non-HCV patients (p = 0.001).

CONCLUSIONS

The results demonstrated that HBV was predominantly associated with underlying CLD among this group of patients in India and suggest that HBV coinfection in HCV-infected patients should not be excluded by negative HBsAg status alone.

Authors+Show Affiliations

Department of Microbiology, Faculty of Medicine, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India. saravanan@yrgcare.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19597643

Citation

Saravanan, Shanmugam, et al. "Hepatitis B Virus and Hepatitis C Virus Dual Infection Among Patients With Chronic Liver Disease." Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, vol. 42, no. 2, 2009, pp. 122-8.
Saravanan S, Velu V, Nandakumar S, et al. Hepatitis B virus and hepatitis C virus dual infection among patients with chronic liver disease. J Microbiol Immunol Infect. 2009;42(2):122-8.
Saravanan, S., Velu, V., Nandakumar, S., Madhavan, V., Shanmugasundaram, U., Murugavel, K. G., Balakrishnan, P., Kumarasamy, N., Solomon, S., & Thyagarajan, S. P. (2009). Hepatitis B virus and hepatitis C virus dual infection among patients with chronic liver disease. Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, 42(2), 122-8.
Saravanan S, et al. Hepatitis B Virus and Hepatitis C Virus Dual Infection Among Patients With Chronic Liver Disease. J Microbiol Immunol Infect. 2009;42(2):122-8. PubMed PMID: 19597643.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis B virus and hepatitis C virus dual infection among patients with chronic liver disease. AU - Saravanan,Shanmugam, AU - Velu,Vijayakumar, AU - Nandakumar,Subhadra, AU - Madhavan,Vidya, AU - Shanmugasundaram,Uma, AU - Murugavel,Kailapuri G, AU - Balakrishnan,Pachamuthu, AU - Kumarasamy,Nagalingeswaran, AU - Solomon,Suniti, AU - Thyagarajan,Sadras Panchatcharam, PY - 2009/7/15/entrez PY - 2009/7/15/pubmed PY - 2009/10/9/medline SP - 122 EP - 8 JF - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi JO - J Microbiol Immunol Infect VL - 42 IS - 2 N2 - BACKGROUND AND PURPOSE: Hepatitis B virus (HBV) and hepatitis C virus (HCV) dual infection accounts for a substantial proportion of liver diseases worldwide. Although the exact prevalence is not known, these viral infections are common among patients with chronic liver disease (CLD). This study was performed to determine the prevalence of HBV and HCV dual infection among patients with CLD in Chennai, India. METHODS: 251 patients were tested for the presence of hepatitis B surface antigen (HBsAg), immunoglobulin (Ig)-M/IgG antibody to hepatitis B core antigen (anti-HBc) and anti-HCV antibodies, and HBV-DNA and HCV-RNA by qualitative polymerase chain reaction. RESULTS: Coinfection with HCV and HBV was detected in 15 patients (5.9%), 12 of whom (80.0%) were positive for HCV-RNA and IgG anti-HBc with no evidence of HBV-DNA, while 3 HBsAg-negative patients (20.0%) were positive for HBV-DNA in addition to HCV-RNA. Liver function test profiles were significantly altered for HCV-positive patients compared with HBV-positive and HBV/HCV coinfected patients (p = 0.001). Bilirubin and alanine aminotransferase levels were significantly raised in coinfected patients compared with non-HBV, non-HCV patients (p = 0.001). CONCLUSIONS: The results demonstrated that HBV was predominantly associated with underlying CLD among this group of patients in India and suggest that HBV coinfection in HCV-infected patients should not be excluded by negative HBsAg status alone. SN - 1995-9133 UR - https://www.unboundmedicine.com/medline/citation/19597643/Hepatitis_B_virus_and_hepatitis_C_virus_dual_infection_among_patients_with_chronic_liver_disease_ L2 - http://www.diseaseinfosearch.org/result/4280 DB - PRIME DP - Unbound Medicine ER -