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Clinical profile and treatment outcome of diabetic ketoacidosis.
J Assoc Physicians India. 1991 May; 39(5):379-81.JA

Abstract

Data on 143 consecutive cases with diabetic ketoacidosis (DKA) seen during the past 6 years were analysed. The group included 60 males and 83 females, aged 8-70 years (21.5 +/- 4.2). Ninety five (66.5%) were known diabetics, while 48 had DKA as the first clinical presentation. The major recognised precipitating factors were infection in 42 patients (30%) and omission of insulin in 29 patients (20%). The approximate duration of DKA prior to hospital admission ranged from 4 to 96 hours. The range of biochemical alterations on admission were: blood glucose 9.7-51.1 mmol/l, (19 +/- 4.6), potassium 3.0 to 6.9 mmol/l (5.8 +/- 1.2), sodium 132 to 148 mmol/l (138 +/- 7.5), urea 4.67 to 26.17 mmol/l (11.3 +/- 2.9) and arterial pH 6.9 to 7.34. Therapy in all patients consisted of correction of fluid and electrolyte imbalance, insulin and suitable antibiotics. Forty three patients received low dose hourly insulin while others received it in the conventional schedule. Thirty four patients (23.7%) died. The parameters which could be related to mortality included (1) duration of DKA prior to admission, (2) severity of acidosis, and (3) severity of peripheral vascular insufficiency.

Authors+Show Affiliations

Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1960152

Citation

Matoo, V K., et al. "Clinical Profile and Treatment Outcome of Diabetic Ketoacidosis." The Journal of the Association of Physicians of India, vol. 39, no. 5, 1991, pp. 379-81.
Matoo VK, Nalini K, Dash RJ. Clinical profile and treatment outcome of diabetic ketoacidosis. J Assoc Physicians India. 1991;39(5):379-81.
Matoo, V. K., Nalini, K., & Dash, R. J. (1991). Clinical profile and treatment outcome of diabetic ketoacidosis. The Journal of the Association of Physicians of India, 39(5), 379-81.
Matoo VK, Nalini K, Dash RJ. Clinical Profile and Treatment Outcome of Diabetic Ketoacidosis. J Assoc Physicians India. 1991;39(5):379-81. PubMed PMID: 1960152.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical profile and treatment outcome of diabetic ketoacidosis. AU - Matoo,V K, AU - Nalini,K, AU - Dash,R J, PY - 1991/5/1/pubmed PY - 1991/5/1/medline PY - 1991/5/1/entrez SP - 379 EP - 81 JF - The Journal of the Association of Physicians of India JO - J Assoc Physicians India VL - 39 IS - 5 N2 - Data on 143 consecutive cases with diabetic ketoacidosis (DKA) seen during the past 6 years were analysed. The group included 60 males and 83 females, aged 8-70 years (21.5 +/- 4.2). Ninety five (66.5%) were known diabetics, while 48 had DKA as the first clinical presentation. The major recognised precipitating factors were infection in 42 patients (30%) and omission of insulin in 29 patients (20%). The approximate duration of DKA prior to hospital admission ranged from 4 to 96 hours. The range of biochemical alterations on admission were: blood glucose 9.7-51.1 mmol/l, (19 +/- 4.6), potassium 3.0 to 6.9 mmol/l (5.8 +/- 1.2), sodium 132 to 148 mmol/l (138 +/- 7.5), urea 4.67 to 26.17 mmol/l (11.3 +/- 2.9) and arterial pH 6.9 to 7.34. Therapy in all patients consisted of correction of fluid and electrolyte imbalance, insulin and suitable antibiotics. Forty three patients received low dose hourly insulin while others received it in the conventional schedule. Thirty four patients (23.7%) died. The parameters which could be related to mortality included (1) duration of DKA prior to admission, (2) severity of acidosis, and (3) severity of peripheral vascular insufficiency. SN - 0004-5772 UR - https://www.unboundmedicine.com/medline/citation/1960152/Clinical_profile_and_treatment_outcome_of_diabetic_ketoacidosis_ DB - PRIME DP - Unbound Medicine ER -