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Perineural invasion is a prognostic factor for biochemical failure after radical prostatectomy.
Int J Urol. 2009 Aug; 16(8):682-6.IJ

Abstract

OBJECTIVES

To identify the prognostic significance of lymphovascular invasion (LVI) and perineural invasion (PNI) in patients undergoing radical prostatectomy for prostate cancer.

METHODS

Overall, 237 patients who had undergone radical prostatectomy for prostate cancer between 1995 and 2004 were analyzed for all clinical and pathological factors. The influence of these two pathological features on biochemical failure-free survival was evaluated by univariate and multivariate analysis.

RESULTS

Lymphovascular and perineural invasion were identified in 41 (17.2%) and 100 (42.0%) patients, respectively. LVI and PNI were significantly associated with the preoperative prostate-specific antigen (PSA) level, a higher PSA density, a higher pathological stage, a higher Gleason score, a higher frequency of extracapsular extension, a higher frequency of seminal vesicle invasion, and a higher frequency of a positive resection margin. Positive resection margins (P = 0.001) and perineural invasion (P = 0.011) were identified as independent factors associated with biochemical failure-free survival by the multivariate analysis.

CONCLUSIONS

In this series, PNI was associated with established parameters of biologically aggressive disease, and was an important prognostic factor for biochemical failure-free survival in patients undergoing radical prostatectomy. This finding supports routine evaluation of the PNI status in radical prostatectomy specimens and suggests that patients with PNI should be more closely followed after surgery.

Authors+Show Affiliations

Department of Urology, Seoul National University Hospital, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19602004

Citation

Jeon, Hwang Gyun, et al. "Perineural Invasion Is a Prognostic Factor for Biochemical Failure After Radical Prostatectomy." International Journal of Urology : Official Journal of the Japanese Urological Association, vol. 16, no. 8, 2009, pp. 682-6.
Jeon HG, Bae J, Yi JS, et al. Perineural invasion is a prognostic factor for biochemical failure after radical prostatectomy. Int J Urol. 2009;16(8):682-6.
Jeon, H. G., Bae, J., Yi, J. S., Hwang, I. S., Lee, S. E., & Lee, E. (2009). Perineural invasion is a prognostic factor for biochemical failure after radical prostatectomy. International Journal of Urology : Official Journal of the Japanese Urological Association, 16(8), 682-6. https://doi.org/10.1111/j.1442-2042.2009.02331.x
Jeon HG, et al. Perineural Invasion Is a Prognostic Factor for Biochemical Failure After Radical Prostatectomy. Int J Urol. 2009;16(8):682-6. PubMed PMID: 19602004.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Perineural invasion is a prognostic factor for biochemical failure after radical prostatectomy. AU - Jeon,Hwang Gyun, AU - Bae,Jungbum, AU - Yi,Jun-Seok, AU - Hwang,In Sik, AU - Lee,Sang Eun, AU - Lee,Eunsik, Y1 - 2009/07/07/ PY - 2009/7/16/entrez PY - 2009/7/16/pubmed PY - 2009/10/31/medline SP - 682 EP - 6 JF - International journal of urology : official journal of the Japanese Urological Association JO - Int J Urol VL - 16 IS - 8 N2 - OBJECTIVES: To identify the prognostic significance of lymphovascular invasion (LVI) and perineural invasion (PNI) in patients undergoing radical prostatectomy for prostate cancer. METHODS: Overall, 237 patients who had undergone radical prostatectomy for prostate cancer between 1995 and 2004 were analyzed for all clinical and pathological factors. The influence of these two pathological features on biochemical failure-free survival was evaluated by univariate and multivariate analysis. RESULTS: Lymphovascular and perineural invasion were identified in 41 (17.2%) and 100 (42.0%) patients, respectively. LVI and PNI were significantly associated with the preoperative prostate-specific antigen (PSA) level, a higher PSA density, a higher pathological stage, a higher Gleason score, a higher frequency of extracapsular extension, a higher frequency of seminal vesicle invasion, and a higher frequency of a positive resection margin. Positive resection margins (P = 0.001) and perineural invasion (P = 0.011) were identified as independent factors associated with biochemical failure-free survival by the multivariate analysis. CONCLUSIONS: In this series, PNI was associated with established parameters of biologically aggressive disease, and was an important prognostic factor for biochemical failure-free survival in patients undergoing radical prostatectomy. This finding supports routine evaluation of the PNI status in radical prostatectomy specimens and suggests that patients with PNI should be more closely followed after surgery. SN - 1442-2042 UR - https://www.unboundmedicine.com/medline/citation/19602004/Perineural_invasion_is_a_prognostic_factor_for_biochemical_failure_after_radical_prostatectomy_ L2 - https://doi.org/10.1111/j.1442-2042.2009.02331.x DB - PRIME DP - Unbound Medicine ER -